Evaluation of the Methylation Status of Tumour Suppressor Genes for Predicting Bacillus Calmette-Guérin Response in Patients With T1G3 High-Risk Bladder Tumours

2011 ◽  
Vol 60 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Miriam Agundez ◽  
Laura Grau ◽  
Joan Palou ◽  
Ferrán Algaba ◽  
Humberto Villavicencio ◽  
...  
Keyword(s):  
High Risk ◽  
Methylation Status ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Bacillus Calmette Guerin ◽  
Suppressor Genes ◽  
Bladder Tumours

Aberrant methylation of tumour suppressor genes WT1, GATA5 and PAX5 in hepatocellular carcinoma

2016 ◽  
Vol 54 (12) ◽  
Author(s):  
Martin Mžik ◽  
Marcela Chmelařová ◽  
Stanislav John ◽  
Jan Laco ◽  
Ondřej Slabý ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Promoter Methylation ◽  
Mrna Level ◽  
Methylation Status ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Aberrant Methylation ◽  
Suppressor Genes ◽  
Tissue Samples ◽  
Differentially Methylated Genes

AbstractBackground:Aberrant hypermethylation of tumour suppressor genes (TSGs) occurring in hepatocellular carcinoma (HCC) could provide a mean of molecular characterisation of this cancer. The aim of this study was to investigate promoter methylation and gene expression of selected TSGs in HCC to identify candidate genes for further validation as potential biomarkers.Methods:Methylation-specific multiplex ligation-dependent probe amplification method was used to measure the methylation status of 25 TSGs in 49 HCC samples and 36 corresponding non-cancerous liver tissue samples. Relative expression of the differentially methylated genes was assessed at the mRNA level using quantitative PCR.Results:We observed a significantly higher methylation in genesConclusions:HCC evince aberrant promoter methylation of

scholarly journals Exclusion of BBC1 and CMAR as candidate breast tumour-suppressor genes

1997 ◽  
Vol 76 (12) ◽  
pp. 1550-1553 ◽  
Author(s):  
E Moerland ◽  
MH Breuning ◽  
CJ Cornelisse ◽  
AM Cleton-Jansen
Keyword(s):  
Breast Tumour ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

Infrequent loss of heterozygosity of the major tumour suppressor genes in Indian oral cancers

2002 ◽  
Vol 31 (4) ◽  
pp. 414-418 ◽  
Author(s):  
S. Kannan ◽  
H. Yokozaki ◽  
K. Jayasree ◽  
P. Sebastian ◽  
A. Mathews ◽  
...  
Keyword(s):  
Loss Of Heterozygosity ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Oral Cancers

Tumour Suppressor Genes in Hodgkin’s Disease

1995 ◽  
pp. 209-222
Author(s):  
Miguel A. Piris ◽  
Juan C. Martinez ◽  
Margarita Sanchez-Beato ◽  
Juan F. Garcia ◽  
Carmen Bellas ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes

scholarly journals Pan-cancer characterisation of microRNA with hallmarks of cancer reveals role of microRNA-mediated downregulation of tumour suppressor genes

2017 ◽  
Author(s):  
Andrew Dhawan ◽  
Jacob G. Scott ◽  
Adrian L. Harris ◽  
Francesca M. Buffa
Keyword(s):  
Penalized Regression ◽  
Tumour Suppressor ◽  
The Cancer Genome Atlas ◽  
Clinical Samples ◽  
Tumour Suppressor Genes ◽  
Alternative Mechanism ◽  
Mirna Regulation ◽  
Hallmarks Of Cancer ◽  
Suppressor Genes ◽  
Copy Number Changes

microRNA are key regulators of the human transcriptome across a number of diverse biological processes, such as development, aging, and cancer, where particular miRNA have been identified as tumour suppressive and oncogenic. In this work, we sought to elucidate, in a comprehensive manner, across 15 epithelial cancer types comprising 7,316 clinical samples from the Cancer Genome Atlas, the association of miRNA expression and target regulation with the pheno-typic hallmarks of cancer. Utilising penalized regression techniques to integrate transcriptomic, methylation and mutation data, we find evidence for a complex map of interactions underlying the relationship of miRNA regulation and the hallmarks of cancer. This highlighted high redundancy for the oncomiR-1 cluster of oncogenic miRNAs, in particular hsa-miR-17-5p. In addition, we reveal extensive miRNA regulation of tumour suppressor genes such as PTEN, FAT4, and CDK12, uncovering an alternative mechanism of repression in the absence of mutation, methylation or copy number changes.

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