A modified protocol for isolation of retinal microglia from the pig

2021 ◽  
Vol 207 ◽  
pp. 108584
Author(s):  
Yahan Zhang ◽  
Anna Lena Erhard ◽  
Tanja Plagemann ◽  
Nicole Eter ◽  
Peter Heiduschka
Keyword(s):  
Retinal Microglia

Retinal microglia polarization in diabetic retinopathy

2021 ◽  
Vol 38 ◽  
Author(s):  
Xin Li ◽  
Zi-Wei Yu ◽  
Hui-Yao Li ◽  
Yue Yuan ◽  
Xin-Yuan Gao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Diabetic Retinopathy ◽  
Cytokine Production ◽  
Immune Cell ◽  
Microvascular Disease ◽  
Retinal Diseases ◽  
Microglia Polarization ◽  
Retinal Microglia ◽  
The Central Nervous System ◽  
Retinal Neurodegeneration

Abstract Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.

907 Proliferation and cytokine release of activated retinal microglia and ATP receptor involvement

1997 ◽  
Vol 28 ◽  
pp. S112
Author(s):  
Katsuko Morigiwa ◽  
Miho Sugioka ◽  
Masayuki Yamashita ◽  
Yutaka Fukuda
Keyword(s):  
Cytokine Release ◽  
Retinal Microglia

Retinal Microglia and Uveal Tract Dendritic Cells and Macrophages Are Not CX3CR1 Dependent in Their Recruitment and Distribution in the Young Mouse Eye

2008 ◽  
Vol 49 (4) ◽  
pp. 1599 ◽  
Author(s):  
Jelena Kezic ◽  
Heping Xu ◽  
Holly R. Chinnery ◽  
Connor C. Murphy ◽  
Paul G. McMenamin
Keyword(s):  
Dendritic Cells ◽  
Young Mouse ◽  
Uveal Tract ◽  
Retinal Microglia

scholarly journals Sigma Receptor Ligand, (+)-Pentazocine, Suppresses Inflammatory Responses of Retinal Microglia

2014 ◽  
Vol 55 (6) ◽  
pp. 3375 ◽  
Author(s):  
Jing Zhao ◽  
Yonju Ha ◽  
Gregory I. Liou ◽  
Graydon B. Gonsalvez ◽  
Sylvia B. Smith ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Sigma Receptor ◽  
Receptor Ligand ◽  
Retinal Microglia

scholarly journals In Situ Dividing and Phagocytosing Retinal Microglia Express Nestin, Vimentin, and NG2 In Vivo

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e22408 ◽  
Author(s):  
Stefanie G. Wohl ◽  
Christian W. Schmeer ◽  
Thomas Friese ◽  
Otto W. Witte ◽  
Stefan Isenmann
Keyword(s):  
Retinal Microglia

scholarly journals Complement facilitates developmental microglial pruning of astrocyte and vascular networks

2022 ◽  
Author(s):  
Gopalan Gnanaguru ◽  
Steven J Tabor ◽  
Kentaro Yuda ◽  
Ryo Mukai ◽  
Jörg Köhl ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Cell ◽  
Vascular Density ◽  
Vascular Networks ◽  
Vascular Patterning ◽  
Vascular Growth ◽  
Vascular Bed ◽  
Retinal Microglia ◽  
The Central Nervous System

Microglia, the resident immune cell of the central nervous system, play a pivotal role in facilitating neurovascular development through mechanisms that are not fully understood. This current work resolves a previously unknown role for microglia in facilitating the developmental pruning of the astrocytic template resulting in a spatially organized retinal vascular bed. Mechanistically, our study identified that local microglial expression of complement (C)3 and C3aR is necessary for the regulation of astrocyte patterning and vascular growth during retinal development. Ablation of retinal microglia, loss of C3 or C3aR reduced developmental pruning and clearance of astrocytic bodies leading to increased astrocyte density leading to altered vascular patterning during retinal vascular development. This data demonstrates that C3/C3aR signaling is an important checkpoint required for the finetuning of vascular density during neuroretinal development.

scholarly journals Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia

2020 ◽  
Vol 258 (9) ◽  
pp. 1965-1974
Author(s):  
Alexa Klettner ◽  
Antonia Harms ◽  
Vicki Waetzig ◽  
Jan Tode ◽  
Konstantine Purtskhvanidze ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Silicone Oil ◽  
Retinal Microglia

Retinal microglia: Just bystander or target for therapy?

2015 ◽  
Vol 45 ◽  
pp. 30-57 ◽  
Author(s):  
Marcus Karlstetter ◽  
Rebecca Scholz ◽  
Matt Rutar ◽  
Wai T. Wong ◽  
Jan M. Provis ◽  
...  
Keyword(s):  
Retinal Microglia

Retinal microglia – A key player in healthy and diseased retina

2019 ◽  
Vol 173 ◽  
pp. 18-40 ◽  
Author(s):  
Gurugirijha Rathnasamy ◽  
Wallace S. Foulds ◽  
Eng-Ang Ling ◽  
Charanjit Kaur
Keyword(s):  
Retinal Microglia
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