Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis

2019 ◽  
Vol 119 ◽  
pp. 1-6 ◽  
Author(s):  
Carl P.C. Chen ◽  
Jean-Lon Chen ◽  
Chih-Chin Hsu ◽  
Yu-Cheng Pei ◽  
Wei-Han Chang ◽  
...  
Keyword(s):  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Geriatric Patients ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Effectiveness of intraosseous infiltration of autologous platelet-rich plasma in the area of the bone marrow edema in osteoarthritis of the knee joint

2019 ◽  
pp. 47-53 ◽  
Author(s):  
A.V. Lychagin ◽  
A.V. Garkavi ◽  
O.I. Islaieh ◽  
P.I. Katunyan ◽  
D.S. Bobrov ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Knee Joint ◽  
Bone Marrow Edema ◽  
Platelet Rich Plasma ◽  
Pain Syndrome ◽  
Osteoarthritis Of The Knee ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Marrow Edema

Osteoarthritis (OA) affects both elderly people, for whom it is one of the main causes of disability, and people of active working age and is an urgent clinical and social problem of resistance of pain syndrome to therapy. The disease is characterized by both destruction of intra-articular and paraarticular structures, such as subchondral bone. While OA is an important sign of pathological changes believe the bone marrow edema (BME). This work examines the effect of BME on development osteoarthritis, and therapeutic approaches to the management of patients with OA. The aim of the study was to develop a method of treatment of BME in OA of the knee joint by locally intraosseous injection of autologous thrombotic-rich plasma (PRP) into the edema zone. In this study 17 patients with the diagnosis: Osteoarthritis II-IV Grade. according to the classification of Kellgren–Lawrence, in which areas of local inflammation in the form of BME were detected on MRI in the subchondral zone in accordance with the international classification of WORMS (Whole Organ Magnetic Resonance Imaging Score). The mean age of patients was 41,7 ± 14,3 years, 10 of them were women and 7 men. Patients were treated with autological platelet-rich plasma under x-ray control injected from extra-articular intraosseous access in the area of BME. Evaluation of effectiveness of treatment performed by VAS, WOMAC and KOOS scales, before the introduction of autoplasma, after 1 and 3 months after the start of treatment. Three months after the manipulation, there was a statistically significant decrease in the intensity of inflammatory syndrome: for WOMAC by 17.5%, for KOOS by 19.4% and for VAS by 33,1% (p < 0,01). Thus, the efficiency of intraosseous Infiltration of autologous platelet-rich plasma in the treatment of patients with OA, accompanied by edema of the bone marrow in the subchondral zone, was proved.

scholarly journals Role of Intra Articular Injections of Autologous Platelet Rich Plasma in Osteoarthritis of Knee Joint

2019 ◽  
Vol 6 (03) ◽  
pp. 4373-4380
Author(s):  
Dr Bansilal Karra ◽  
Dr.koppula Sreeja ◽  
Velicharla Raviteja
Keyword(s):  
Growth Factors ◽  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Knee Joints ◽  
Prospective Longitudinal Study ◽  
Osteoarthritis Of Knee ◽  
Autologous Platelet Rich Plasma ◽  
Prospective Longitudinal ◽  
Autologous Platelet

Osteoarthritis is the most common form of arthritis and a leading cause of chronic disability, to a great extent in knee and/or hip joints. Osteoarthritis, commonly known as wear and tear in which a protective cartilage on the end of the bones wears down over time. osteoarthritis of the knees is one of five leading causes for disability among non-institutionalized adults. Osteoarthritis is the fourth leading cause of 'years lived with disability' (YLD), accounting for 3.0% of totals global YLD's. As per WHO by 2030. The most common symptoms of knee osteoarthritis are pain and physical limitations that have a significant effect on the individual's quality of life and her or his social and economic activities. Osteoarthritis diseases are a result of both mechanical and biological events that destabilize the normal biological coupling of degradation and synthesis of articular cartilage, chondrocytes, extracellular matrix, subchondral bone and subsequently synovial fluid. Current research efforts are focused on the identification of key biochemical pathways that can be targeted therapeutically through biological intervention for cartilage repair. Autologous platelet-rich plasma (PRP), which contains a pool of growth factors, appears to offer an easy solution for delivering multiple growth factors needed for tissue repair. PRP therapy provides delivery of a highly concentrated of growth factors to accelerate healing. The present study has been undertaken in Gandhi Medical College, Hospital, Hyderabad, Telangana, India to study the role of PRP in the osteoarthritis of knee joint. In this study PRP from the patient’s own blood i.e. autologous PRP has been immediately infiltrated into their knee joints with osteoarthritis and the results of injection of PRP have been observed and assess the functional outcome. It is a prospective longitudinal study on 100 patients with 161 primary osteoarthritic knee joints of Kellgren Lawrence radiological grade I-61 and II - 100. Patients were assessed with WOMAC (Western Ontario McMaster Universities Arthritis Index) scoring pre injection of PRP and post injection period of 1 month and 6 months. A reduction in WOMAC score is suggestive of improvement in the patient’s condition. In this study, the pain scores of the patients have decreased on the day of infiltration to one month and six months. Their mean scores have decreased from the day of infiltration to one month and six months. All the patients have started showing improvement at around two weeks and over all, the pain intensity has decreased in severity. It can be concluded that the efficacy of the PRP treatment from zero day to sixth month is statistically significant.

scholarly journals Role of intra articular injection of autologous platelet rich plasma in osteoarthrosis of the knee joint

2020 ◽  
Vol 4 (4) ◽  
pp. 01-06
Author(s):  
Dr. Kalyan Kumar ◽  
Dr. Siva Reddy Panapana ◽  
Dr. Supraja Movva ◽  
Dr. Satya Kumar Koduru
Keyword(s):  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Arthroscopic laser surgery combined with intraosseous infiltration of autologous platelet-rich plasma in the treatment of knee osteoarthritis

2020 ◽  
Vol 24 (1) ◽  
pp. 34-38
Author(s):  
A. V. Lychagin ◽  
A. V. Garkavi ◽  
S. V. Ivannikov ◽  
O. I. Islaieh
Keyword(s):  
Knee Joint ◽  
Laser Surgery ◽  
Platelet Rich Plasma ◽  
Cartilage Damage ◽  
Mri Findings ◽  
Prolonged Effect ◽  
Autologous Platelet Rich Plasma ◽  
Assessment Scales ◽  
Optical Transducer ◽  
Autologous Platelet

Purpose. To improve the cure of knee osteoarthirtis using a combination of arthroscopic laser surgery and intraosseous infiltration of autologous platelet-rich plasma (PRP). Material and methods. 32 patients (18 men and 14 women) with osteoarthrosis (OA) of the knee joint, degree II–III (by Kellgren–Lawrence classification), participated in the study. By MRI findings, all patients had meniscus and cartilage damage. The arthroscopic intervention was done with laser device «LSP IRE Polyus», wavelength 0.97 mkm. In addition to the arthroscopy, patients were made extra-articular intraosseous infiltration of autologous platelet-rich plasma topically into the altered subchondral bone under the control of an electronic optical transducer (OEC Fluorostar 7900 COMPACT 2). The evaluation of treatment efficacy was made using WOMAC and KOOS knee function assessment scales, as well as VAS scale (pain intensity) before surgery and 1 and 3 months after the treatment beginning. Results. In 3 months, WOMAC scale showed the improved knee joint function by 25.38 points, KOOS scale – by 37.4 points and VAS scale – by 35 points (p < 0.01). Thus, the performed curative technique increased the support capacity, range of motion in the knee joint, less pain – all these contributed to the achievement of prolonged effect.

Sign in / Sign up

Export Citation Format

Share Document