scholarly journals Role of Intra Articular Injections of Autologous Platelet Rich Plasma in Osteoarthritis of Knee Joint

2019 ◽  
Vol 6 (03) ◽  
pp. 4373-4380
Author(s):  
Dr Bansilal Karra ◽  
Dr.koppula Sreeja ◽  
Velicharla Raviteja
Keyword(s):  
Growth Factors ◽  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Knee Joints ◽  
Prospective Longitudinal Study ◽  
Osteoarthritis Of Knee ◽  
Autologous Platelet Rich Plasma ◽  
Prospective Longitudinal ◽  
Autologous Platelet

Osteoarthritis is the most common form of arthritis and a leading cause of chronic disability, to a great extent in knee and/or hip joints. Osteoarthritis, commonly known as wear and tear in which a protective cartilage on the end of the bones wears down over time. osteoarthritis of the knees is one of five leading causes for disability among non-institutionalized adults. Osteoarthritis is the fourth leading cause of 'years lived with disability' (YLD), accounting for 3.0% of totals global YLD's. As per WHO by 2030. The most common symptoms of knee osteoarthritis are pain and physical limitations that have a significant effect on the individual's quality of life and her or his social and economic activities. Osteoarthritis diseases are a result of both mechanical and biological events that destabilize the normal biological coupling of degradation and synthesis of articular cartilage, chondrocytes, extracellular matrix, subchondral bone and subsequently synovial fluid. Current research efforts are focused on the identification of key biochemical pathways that can be targeted therapeutically through biological intervention for cartilage repair. Autologous platelet-rich plasma (PRP), which contains a pool of growth factors, appears to offer an easy solution for delivering multiple growth factors needed for tissue repair. PRP therapy provides delivery of a highly concentrated of growth factors to accelerate healing. The present study has been undertaken in Gandhi Medical College, Hospital, Hyderabad, Telangana, India to study the role of PRP in the osteoarthritis of knee joint. In this study PRP from the patient’s own blood i.e. autologous PRP has been immediately infiltrated into their knee joints with osteoarthritis and the results of injection of PRP have been observed and assess the functional outcome. It is a prospective longitudinal study on 100 patients with 161 primary osteoarthritic knee joints of Kellgren Lawrence radiological grade I-61 and II - 100. Patients were assessed with WOMAC (Western Ontario McMaster Universities Arthritis Index) scoring pre injection of PRP and post injection period of 1 month and 6 months. A reduction in WOMAC score is suggestive of improvement in the patient’s condition. In this study, the pain scores of the patients have decreased on the day of infiltration to one month and six months. Their mean scores have decreased from the day of infiltration to one month and six months. All the patients have started showing improvement at around two weeks and over all, the pain intensity has decreased in severity. It can be concluded that the efficacy of the PRP treatment from zero day to sixth month is statistically significant.

scholarly journals Role of intra articular injection of autologous platelet rich plasma in osteoarthrosis of the knee joint

2020 ◽  
Vol 4 (4) ◽  
pp. 01-06
Author(s):  
Dr. Kalyan Kumar ◽  
Dr. Siva Reddy Panapana ◽  
Dr. Supraja Movva ◽  
Dr. Satya Kumar Koduru
Keyword(s):  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Production cost of autologous platelet rich plasma gel

2019 ◽  
Vol 27 ◽  
Author(s):  
Andrea Pinto Leite Ribeiro ◽  
Beatriz Guitton Renaud Baptista de Oliveira
Keyword(s):  
Health System ◽  
Direct Cost ◽  
Platelet Rich Plasma ◽  
Production Costs ◽  
Prospective Longitudinal Study ◽  
Material Resources ◽  
Unified Health System ◽  
Autologous Platelet Rich Plasma ◽  
Prospective Longitudinal ◽  
Autologous Platelet

Objective: to estimate the direct cost of producing autologous platelet rich plasma gel. Method: an economic, prospective, longitudinal study with direct cost estimation, from the perspective of the Unified Health System, conducted in a university hospital in the state of Rio de Janeiro, over a period of 12 weeks. It was approved by the Ethics Committee of the School of Medicine. Direct observation of 18 participants was conducted. Material and human resources categories were analyzed for production costs. Results: the cost of producing platelet rich plasma gel was US $4.88 per session, for a total of US $5.16, when the material resources per unit were considered in the Unified Health System. The time to complete the procedure was approximately 22 minutes. Conclusion: the production of platelet rich plasma gel involves low cost material resources for both blood collection and preparation, enabling universal access to treatment. The procedure requires trained staff in an appropriate location; it is a safe and inexpensive technology.

scholarly journals ROLE OF PLATELET RICH PLASMA IN TREATMENT OF CHRONIC NON-HEALING VENOUS ULCER

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Firdaus A. Dekhaiya ◽  
Jignesh K. Joshi ◽  
Sarav Bamania
Keyword(s):  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Healing Process ◽  
Venous Ulcer ◽  
Lower Limbs ◽  
Venous Ulcers ◽  
Autologous Platelet Rich Plasma ◽  
Adhesive Proteins ◽  
Autologous Platelet

Introduction: Venous ulcers are wounds that are thought to occur due to improper functioning of venous valves, usually of the lower limbs. Considering that PRP is a source of growth factors, and consequently has mitogenic, angiogenic, and chemotactic properties, it represents an adjunctive treatment for recalcitrant wounds. Moreover, PRP provides the wound with adhesive proteins, such as fibrinogen, which are important in wound healing. PRP contain more amount of platelets, cytokines and growth factors which are dispersed in a very small amount of plasma which can be prepared from a sample of centrifuged autologous blood. Application of PRP has been reported to be effective in both acute as well as chronic non healing venous ulcers. Aim and Objective: To evaluate the efficacy of autologous platelet rich plasma in the management of chronic venous ulcer. Material and Method: A Prospective study conducted on 100 patients of chronic venous ulcers admitted in Sir T. Hospital Bhavnagar from June 2018 to June 2019 after fulfilled our inclusion and exclusion criteria. PRP then injected intalesionally inside and around the periphery of the wound/ulcer. This process was done once/week for 12 weeks. At every week, the area and volume of ulcer was calculated and photographs were taken. Result: All the patients showed healing of the ulcer with reduction in size of ulcer more than 90% was observed in 72 patients, followed by 80–90% reduction in wound size in 18 patients after the 12 weeks follow-up. Overall, significant reduction in size of ulcer was observed in all the treated patients. Conclusion: Autologous platelet rich plasma (PRP) as an autologous method, it is biocompatible, simple, safe, affordable and less expensive procedure in the treatment of chronic venous ulcers. PRP is found to be useful in improving and enhancing the healing process in chronic venous leg ulcers without any side effect. Keywords:  Venous ulcer, Platelet rich plasma

Role of autologous platelet rich plasma in management of chronic wounds

Chirurgia ◽  
2021 ◽  
Vol 34 (2) ◽  
Author(s):  
Walid M. GAMAL ◽  
Mohammed A. OMAR ◽  
Aly H. RASHWAN ◽  
Abdrheem F. MOHAMED
Keyword(s):  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Sickle erythrocytes induce prostacyclin and thromboxane synthesis by isolated perfused rat lungs

1997 ◽  
Vol 272 (4) ◽  
pp. L597-L602 ◽  
Author(s):  
B. O. Ibe ◽  
J. Morris ◽  
J. Kurantsin-Mills ◽  
J. U. Raj
Keyword(s):  
Constant Pressure ◽  
Platelet Rich Plasma ◽  
Cell Disease ◽  
Rat Lungs ◽  
Sickle Erythrocytes ◽  
Autologous Platelet Rich Plasma ◽  
Pg E2 ◽  
Isolated Lungs ◽  
Autologous Platelet

The role of eicosanoids in the pathogenesis of acute or chronic lung syndrome in sickle cell disease is unknown. We investigated the synthesis of prostacyclin (PGI2), thromboxane (Tx) A2, and prostaglandin (PG) E2 by three groups of isolated rat lungs perfused with buffer (GPBS), normal (HbAA), and sickle (HbSS) erythrocyte suspensions. Isolated lungs were perfused at a constant pressure and flow rate (Q) of 40 ml x kg(-1) x min(-1) with GPBS or 7% erythrocyte suspensions for 15 min. Autologous platelet-rich plasma (PRP) was added, and perfusion was continued for 15 min and then at two times Q for another 15 min. Perfusate samples were assayed for the specific eicosanoids. Perfusate level of PGI2 in GPBS lungs was the least among the three groups. However, the PGI2 level in HbSS lungs was 90% higher than from HbAA lungs after 15 min of perfusion and was 180% higher on perfusion with PRP. Additionally, coperfusion of erythrocytes and PRP augmented perfusate levels of TxA2 and PGE2 over 1,000% more in HbSS than HbAAlungs. These data show that HbSS erythrocytes increased perfusate levels of the eicosanoids, suggesting increased synthesis, perhaps due to aberrant erythrocyte-endothelium interactions.

scholarly journals REPARATIVE PROCESSES FEATURES IN TROPHIC ULCERS CAUSED BY DIABETES MELLITUS WITH THE USE OF PLATELET-RICH PLASMA

2020 ◽  
Vol 73 (10) ◽  
pp. 2150-2155
Author(s):  
Igor D. Duzhiy ◽  
Andrii S. Nikolaienko ◽  
Vasyl M. Popadynets ◽  
Oleksandr V. Kravets ◽  
Igor Y. Hresko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factors ◽  
Comparison Group ◽  
Platelet Rich Plasma ◽  
Main Group ◽  
Lower Limbs ◽  
Before And After ◽  
Autologous Platelet Rich Plasma ◽  
Inflammatory Changes ◽  
Autologous Platelet

The aim: Was following: the improvement of the treatment results of the lower limbs ulcers, caused by the diabetes mellitus by using our technique of the platelet-rich plasma application; the study of the features of the morphological and immunohistochemical changes, and the effect of the growth factors of the platelet-rich plasma on the regeneration and healing of the ulcers. Materials and methods: 38 patients with the trophic ulcers of the lower limbs, caused by diabetes mellitus were involved in the study. To assess the morphological features of the reparative processes before and after the treatment with PRP, the histological and immunohystochemical studies of the biopsy specimen of ulcers were carried out. Results: The total epithelialization of the ulcers in the patients from the main group was achieved on 46.5 day, and in the comparison group – 81.7 day. The light and optical study of the specimen of the main group, using the autologous platelet-rich plasma revealed the elimination of the destructive changes and reduction of the mixed-cellular infiltration compared to the patients from the comparison group. The immunohystochemical study revealed the increase of the growth factors receptors. Conclusions: The usage of the autologous platelet-rich plasma in the treatment of the trophic ulcers results in the rapid regeneration by the decrease of the destructive and inflammatory changes as well as the improvement of the vascularization.

scholarly journals Role of platelet-rich plasma in early osteoarthritis of knee joint: Experience from a tertiary care center in Pakistan

2019 ◽  
Vol 27 (2) ◽  
pp. 230949901985395 ◽  
Author(s):  
Nusrat Rasheed ◽  
Kamran Hafeez ◽  
Itat Hussain Zaidi ◽  
Raza Askari ◽  
Naseem Rasheed ◽  
...  
Keyword(s):  
Knee Joint ◽  
Platelet Rich Plasma ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center ◽  
Early Osteoarthritis ◽  
Osteoarthritis Of Knee ◽  
Joint Experience
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