Investigating the mechanism of thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human stem cell model system

2017 ◽  
Vol 53 ◽  
pp. S123
Author(s):  
Sara Borst ◽  
Paul Gadue ◽  
Jean Ann Maguire
Keyword(s):  
Stem Cell ◽  
Cell Model ◽  
Model System ◽  
Human Stem Cell ◽  
Stem Cell Model ◽  
Cell Model System

scholarly journals Development of Hematopoietic and Endothelial Cells from Human Embryonic Stem Cells: Lessons from the Studies using Mouse as a Model

2007 ◽  
Vol 7 ◽  
pp. 1950-1964 ◽  
Author(s):  
Anna Jezierski ◽  
Albert Swedani ◽  
Lisheng Wang
Keyword(s):  
Endothelial Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Model System ◽  
Stem Cell Model ◽  
Cell Model System ◽  
Cellular Hierarchy

The current progress using the human embryonic stem cell (hESC) model system has provided much insight into the early origins of the hematopoietic and endothelial lineages, particularly the elusive hemangioblast. Recently, the cellular hierarchy and molecular regulation controlling hematopoietic commitment have been further elucidated. These findings not only provide new insights into early human development, but also advance the knowledge required to develop techniques capable of generating a given cell type for potential clinical applications. This review will focus on the latest advances using the hESC model system, capitalizing on the well-established mouse embryonic stem cell model system, as a means to investigate the lineage commitment events underlying the early embryonic development of human hematopoietic and endothelial cells.

scholarly journals FMR1 loss in a human stem cell model reveals early changes to intrinsic membrane excitability

2020 ◽  
Vol 468 (1-2) ◽  
pp. 93-100
Author(s):  
Sara G. Susco ◽  
Mario A. Arias-García ◽  
Violeta G. López-Huerta ◽  
Amanda Beccard ◽  
Anne M. Bara ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Model ◽  
Human Stem Cell ◽  
Membrane Excitability ◽  
Stem Cell Model

scholarly journals FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS

Brain ◽  
2020 ◽  
Author(s):  
Jasmine Harley ◽  
Cathleen Hagemann ◽  
Andrea Serio ◽  
Rickie Patani
Keyword(s):  
Stem Cell ◽  
Motor Neurons ◽  
Cell Model ◽  
Human Stem Cell ◽  
Stem Cell Model

scholarly journals mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

Cell Reports ◽  
2016 ◽  
Vol 15 (1) ◽  
pp. 86-95 ◽  
Author(s):  
Veronica Costa ◽  
Stefan Aigner ◽  
Mirko Vukcevic ◽  
Evelyn Sauter ◽  
Katharina Behr ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tuberous Sclerosis ◽  
Cell Model ◽  
Human Stem Cell ◽  
Stem Cell Model
Sign in / Sign up

Export Citation Format

Share Document