Faculty Opinions recommendation of A human stem cell model of early Alzheimer's disease pathology in Down syndrome.

2016 ◽  
Author(s):  
Annette Karmiloff-Smith
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Stem Cell ◽  
Cell Model ◽  
Human Stem Cell ◽  
Stem Cell Model ◽  
Early Alzheimer’S Disease

scholarly journals A Human Stem Cell Model of Early Alzheimer's Disease Pathology in Down Syndrome

2012 ◽  
Vol 4 (124) ◽  
pp. 124ra29-124ra29 ◽  
Author(s):  
Y. Shi ◽  
P. Kirwan ◽  
J. Smith ◽  
G. MacLean ◽  
S. H. Orkin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Stem Cell ◽  
Cell Model ◽  
Human Stem Cell ◽  
Stem Cell Model ◽  
Early Alzheimer’S Disease

scholarly journals ID2016 Human mesenchymal stem cell derived model of Alzheimer’s disease – effect of Wnt antagonism in neurodegeneration

2017 ◽  
Vol 4 (S) ◽  
pp. 49
Author(s):  
Manasi Patil
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Drug Targets ◽  
Molecular Mechanisms ◽  
Cell Model ◽  
Human Mesenchymal Stem Cell ◽  
Model Of Alzheimer’S Disease ◽  
Stem Cell Model ◽  
Disease Effect

Alzheimer’s disease (AD), one of the most common types of dementia, is a serious and increasing health problem. This progressive disorder is manifested by loss of memory which worsens over time. Although several causative mechanisms for AD has been identified, the specific molecular mechanisms for the onset and progression of the disease has not yet been elucidated. This is mainly because of the lack of patient tissue at various stages of disease, in order to test and ascertain the molecular progression of AD. To address this lacuna, we have developed a human stem cell model of AD, derived from mesenchymal stem cells (MSCs) of perinatal tissues. We first derived cells of the central nervous system (CNS) from MSCs and then subjected them to AD specific neurodegeneration. Onset of neurodegeneration was ascertained by accumulation of BACE, nAChAR and presenilin. Neuronal generation was first established for expression neuronal specific markers such as nestin, Tuj1, Pax6, Sox1 and 2 by immunocytochemistry and quantitative RT-PCR. In the AD model thus established, we analysed further for the role of Wnt antagonists, sFRP3 and 4 and deciphered a link between inhibition of the Wnt-b catenin pathway and the onset of neurodegeneration. These studies would pave the way for the development of specific biomarkers for progression of AD and novel drug targets based on these biomarkers

scholarly journals Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

2018 ◽  
Author(s):  
Grace O. Mizuno ◽  
Yinxue Wang ◽  
Guilai Shi ◽  
Yizhi Wang ◽  
Junqing Sun ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Stem Cell ◽  
Calcium Signaling ◽  
Neuronal Excitability ◽  
Cell Model ◽  
Stem Cell Model

P3-136: A Genetically Immortalized Human Stem Cell Line: A Promising New Tool for Alzheimer’s Disease Therapy

2016 ◽  
Vol 12 ◽  
pp. P871-P871
Author(s):  
Nicha Puangmalai ◽  
Wipawan Thangnipon ◽  
Alyma Somani ◽  
Clive Ballard ◽  
Martin Broadstock
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Cell Line ◽  
Human Stem Cell ◽  
Stem Cell Line ◽  
Disease Therapy
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