scholarly journals Muscle ciliary neurotrophic factor receptor α helps maintain choline acetyltransferase levels in denervated motor neurons following peripheral nerve lesion

2019 ◽  
Vol 317 ◽  
pp. 202-205 ◽  
Author(s):  
Nancy Lee ◽  
Holly A. Wanek ◽  
A. John MacLennan
Neuroscience ◽  
1999 ◽  
Vol 91 (4) ◽  
pp. 1401-1413 ◽  
Author(s):  
A.J. MacLennan ◽  
B.K. Devlin ◽  
K.L. Neitzel ◽  
D.L. McLaurin ◽  
K.J. Anderson ◽  
...  

2016 ◽  
Vol 36 (8) ◽  
pp. 1272-1286 ◽  
Author(s):  
Jakob Vejby Larsen ◽  
Anders Mejer Kristensen ◽  
Lone Tjener Pallesen ◽  
Johannes Bauer ◽  
Christian Bjerggaard Vægter ◽  
...  

Cardiotrophin-like cytokine:cytokine-like factor-1 (CLC:CLF-1) is a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Mice lacking CLC:CLF-1 die soon after birth due to a suckling defect and show reduced numbers of motor neurons. Humans carrying mutations in CLC:CLF-1 develop similar disorders, known as Sohar-Crisponi or cold-induced sweating syndrome, and have a high risk of early death. It is well known that CLC binds the ciliary neurotrophic factor receptor α (CNTFRα) and is a prerequisite for signaling through the gp130/leukemia inhibitory factor receptor β (LIFRβ) heterodimer, whereas CLF-1 serves to promote the cellular release of CLC. However, the precise role of CLF-1 is unclear. Here, we report that CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRα and sorLA, is a key player in CLC and CNTFRα signaling and turnover. The site for CNTFRα enables CLF-1 to promote CLC:CNTFRα complex formation and signaling. The second site establishes a link between the endocytic receptor sorLA and the tripartite CLC:CLF-1:CNTFRα complex and allows sorLA to downregulate the CNTFRα pool in stimulated cells. Finally, sorLA may bind and concentrate the tripartite soluble CLC:CLF-1:CNTFRα complex on cell membranes and thus facilitate its signaling through gp130/LIFRβ.


Nature ◽  
1990 ◽  
Vol 345 (6274) ◽  
pp. 440-441 ◽  
Author(s):  
Michael Sendtner ◽  
Georg W. Kreutzberg ◽  
Hans Thoenen

Neuroscience ◽  
2011 ◽  
Vol 190 ◽  
pp. 386-397 ◽  
Author(s):  
D. Wu ◽  
M. Raafat ◽  
E. Pak ◽  
S. Hammond ◽  
A.K. Murashov

2003 ◽  
Vol 44 (8) ◽  
pp. 3642 ◽  
Author(s):  
William A. Beltran ◽  
Qi Zhang ◽  
James W. Kijas ◽  
Danian Gu ◽  
Hermann Rohrer ◽  
...  

2019 ◽  
Vol 1 (2) ◽  
pp. 65
Author(s):  
Dewi Poerwandari ◽  
Daisy F Lapasi ◽  
Bayu Aji M

Background: Peripheral nerve lesion after heart surgery was reported on brachial plexus, phrenic nerve, laryngeal recurrent nerve facial nerve, lumbosacral root and spinal cord. Incidence of peroneal communis nerve lesion after heart surgery was not much reported (0,19%). Diagnostic procedure of peripheral nerve lesion are including clinical sign and symptom,  electrophysiology studies and MRI. Rehabilitation management of peripheral nerve lesion are not only management of pain and nerve stimulation, but also walking aid beside cardiac rehabilitation due to cardiac problem.Methods: Reporting two case of peripheral nerve lesion after heart surgery. First case is a female, 37 years old suffered from drop foot two days after mitral valve replacement with mechanic valve. She got pain management, electrical nerve stimulation and therapeutic exercise beside cardiac rehabilitation program. Second case is a female, 9 years old, after total correction of Tetralogy of Fallot, got drop foot at day two. She also got pain management, electrical nerve stimulation and therapeutic exercise beside cardiac rehabilitation.Results: First case result was the drop foot getting better after she entered phase two of cardiac rehabilitation. In the second case, the drop foot was relieved at phase two cardiac rehabilitation and back to normal condition after one year after surgery.Conclusion: In these two case of drop foot after heart surgery, the drop foot was relieved after pain and rehabilitation management beside cardiac rehabilitation.


Pain ◽  
2019 ◽  
Vol 160 (10) ◽  
pp. 2316-2327 ◽  
Author(s):  
Melissa Held ◽  
Franziska Karl ◽  
Eva Vlckova ◽  
Aneta Rajdova ◽  
Fabiola Escolano-Lozano ◽  
...  

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