Sub-chronic exposure to PhIP induces oxidative damage and DNA damage, and disrupts the amino acid metabolism in the colons of Wistar rats

2021 ◽  
pp. 112249
Author(s):  
Xiuli Zhao ◽  
Zeping Shao ◽  
Xiaofei Zhou ◽  
Yongxi Lin ◽  
Jingting Guo ◽  
...  
Keyword(s):  
Dna Damage ◽  
Amino Acid ◽  
Oxidative Damage ◽  
Chronic Exposure ◽  
Amino Acid Metabolism ◽  
Wistar Rats ◽  
Acid Metabolism

Hepatic injury and disturbed amino acid metabolism in mice following prolonged exposure to organophosphorus pesticides

1999 ◽  
Vol 18 (1) ◽  
pp. 33-37 ◽  
Author(s):  
J Gomes ◽  
A H Dawodu ◽  
O Lloyd ◽  
D M Revitt ◽  
S V Anilal
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chronic Exposure ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Hepatic Dysfunction ◽  
Corn Oil ◽  
Organophosphorus Pesticides ◽  
Acetylcholinesterase Activity ◽  
Total Serum

1 Chronic occupational exposure to organophosphorus and carbamate-type pesticides significantly inhibits acetylcholinesterase activity and causes morbidity. This study on mice was designed to evaluate their amino profile and to identify signs of hepatic dysfunction following their chronic exposure to mixtures of organophosphorus pesticides. 2 Laboratory mice were exposed to a formulated mixture of the six organophosphorus pesticides (Dimethoate, Chlorpyrifos, Profenofos, Pirimiphos methyl, Triazophos and Dimethoate) most commonly used in agriculture in this region of the Middle East. Doses (10% of LD50 of the mixture) were given once a week by gavage in corn oil for 7 weeks; the control group was given only corn oil. At the end of the exposure period, mice were culled and blood samples were collected to determine erythrocyte acetylcholinesterase activity, biochemical markers of liver function and concentrations of serum amino acids. 3 Erythrocyte acetylcholinesterase activity and total serum proteins decreased significantly in the exposed group. Serum concentrations of alanine aminotransferase and aspartate aminotransferase, alanine, glutamic acid, glycine, isoleucine, leucine, methionine, ornithine, proline, serine, threonine and valine were significantly increased in the exposed mice, while serum levels of cystine were decreased significantly. There were also non-significant increases in serum alkaline phosphatase, gama-glutamyl transpeptidase and some of the other amino acids. 4 Chronic exposure to mixtures of organophosphorus pesticides is associated with decreased acetylcholinesterase activity, hepatic dysfunction and disturbance of amino acids profile. Biochemical indices of hepatocellular injury and disturbed amino acid metabolism may be of value as markers of chronic exposure to such pesticides.

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Effect of intravenous bicarbonate administration on postoperative amino acid metabolism

1985 ◽  
Vol 4 ◽  
pp. 141-146 ◽  
Author(s):  
K VESTERBERG ◽  
J BERGSTROM ◽  
P FURST ◽  
U LEANDER ◽  
E VINNARS
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Protein and Amino Acid Metabolism in Cancer Cachexia

1996 ◽  
Author(s):  
Peter W. T. Pisters ◽  
Murray F. Brennan
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Cancer Cachexia ◽  
Acid Metabolism

Different sensitivity of glucose and amino acid metabolism to insulin in NIDDM

Diabetes ◽  
1993 ◽  
Vol 42 (12) ◽  
pp. 1868-1877 ◽  
Author(s):  
L. Luzi ◽  
A. S. Petrides ◽  
R. A. De Fronzo
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism
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