Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS. Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

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The study of the pathogenesis of idiopathic central precocious puberty based on gut microbiota

10.21203/rs.3.rs-716354/v2 ◽

2021 ◽

Author(s):

Congfu Huang ◽

Bin Wu ◽

Wei Yang ◽

Junru Chen ◽

Zhenyu Yang ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Gut Microbiota ◽

Carbohydrate Metabolism ◽

Precocious Puberty ◽

Polycystic Ovary ◽

Central Precocious Puberty ◽

Ovary Syndrome ◽

Healthy Group ◽

Idiopathic Central Precocious Puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS. Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

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The Study of the Pathogenesis of Idiopathic Central Precocious Puberty Based on Gut Microbiota

10.21203/rs.3.rs-716354/v3 ◽

2021 ◽

Author(s):

Congfu Huang ◽

Bin Wu ◽

Wei Yang ◽

Junru Chen ◽

Zhenyu Yang ◽

...

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Gut Microbiota ◽

Carbohydrate Metabolism ◽

Precocious Puberty ◽

Polycystic Ovary ◽

Central Precocious Puberty ◽

Ovary Syndrome ◽

Healthy Group ◽

Idiopathic Central Precocious Puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS.Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

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HYPERANDROGENISM AS A CAUSE OF EARLY POLYCYSTIC OVARY SYNDROME (PCOS) IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP)

Pediatric Research ◽

10.1203/00006450-199305001-00065 ◽

1993 ◽

Vol 33 ◽

pp. S14-S14 ◽

Cited By ~ 1

Author(s):

L Lazar ◽

R Kauli ◽

S Bruchis ◽

J Nordenberg ◽

Z Laron ◽

...

Keyword(s):

Polycystic Ovary Syndrome ◽

Precocious Puberty ◽

Polycystic Ovary ◽

Central Precocious Puberty ◽

Ovary Syndrome

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Does a Primary Acceleration of LH Pulse Frequency Underlie an Association between Central Precocious Puberty and Polycystic Ovary Syndrome?

Hormone Research in Paediatrics ◽

10.1159/000104178 ◽

2007 ◽

Vol 68 (6) ◽

pp. 286-287 ◽

Cited By ~ 1

Author(s):

Robert L. Rosenfield

Keyword(s):

Polycystic Ovary Syndrome ◽

Precocious Puberty ◽

Polycystic Ovary ◽

Central Precocious Puberty ◽

Pulse Frequency ◽

Ovary Syndrome

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Gonadotropin releasing hormone analogue treatment of central precocious puberty is not associated with altered prevalence of polycystic ovary syndrome: a single center cohort study

Clinical Diabetes and Endocrinology ◽

10.1186/s40842-021-00129-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Gilad Karavani ◽

Henry H. Chill ◽

Natali Schachter-Safrai ◽

Gan Lomnitz ◽

David Gillis ◽

...

Keyword(s):

Cohort Study ◽

Polycystic Ovary Syndrome ◽

Precocious Puberty ◽

Polycystic Ovary ◽

Central Precocious Puberty ◽

Gonadotropin Releasing Hormone ◽

Hormone Analogue ◽

Ovary Syndrome ◽

Releasing Hormone ◽

Gonadotropin Releasing Hormone Analogue

Abstract Background There is conflicting evidence regarding an association between gonadotropin releasing hormone analogue (GnRHa) therapy and polycystic ovary syndrome (PCOS). This study aimed to compare the prevalence of endocrine disorders, primarily PCOS, between women who had been treated with GnRHa for central precocious puberty (CPP) and those who were not treated. Methods This was a retrospective cohort study, including women diagnosed with central precocious puberty between 1989 and 2011 in a university affiliated tertiary medical center. Data collected included demographic data, medical background, clinical presentation at diagnosis and duration of treatment (zero for non-treated). Gynecologic and endocrine long-term outcomes were compared by treatment group. Results Fifty-one women were included in the study, 27/51 had been treated with gonadotropin releasing hormone analogue (GnRHa). Overall prevalence of PCOS was 19.6%. No statistically significant difference in prevalence of PCOS was demonstrated between the treated and non-treated groups. Similarly, overall prevalence of either clinical or laboratory hyper-androgenism, was 29.4% and 33.3%, for the treatment and non-treatment groups respectively (p = non-significant). Conclusions GnRHa treatment for precocious puberty is not associated with increased risk of polycystic ovary syndrome.

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