scholarly journals The Study of the Pathogenesis of Idiopathic Central Precocious Puberty Based on Gut Microbiota

2021 ◽  
Author(s):  
Congfu Huang ◽  
Bin Wu ◽  
Wei Yang ◽  
Junru Chen ◽  
Zhenyu Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Carbohydrate Metabolism ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Ovary Syndrome ◽  
Healthy Group ◽  
Idiopathic Central Precocious Puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS.Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

scholarly journals The study of the pathogenesis of idiopathic central precocious puberty based on gut microbiota

2021 ◽  
Author(s):  
Congfu Huang ◽  
Bin Wu ◽  
Wei Yang ◽  
Junru Chen ◽  
Zhenyu Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Carbohydrate Metabolism ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Ovary Syndrome ◽  
Healthy Group ◽  
Idiopathic Central Precocious Puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS. Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

scholarly journals The study of the pathogenesis of idiopathic central precocious puberty based on gut microbiota

2021 ◽  
Author(s):  
Congfu Huang ◽  
Bin Wu ◽  
Wei Yang ◽  
Junru Chen ◽  
Zhenyu Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Gut Microbiota ◽  
Carbohydrate Metabolism ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Ovary Syndrome ◽  
Healthy Group ◽  
Idiopathic Central Precocious Puberty

Abstract Object To analyze the correlation between gut microbiota (GM) and hyperandrogenemia, insulin resistance, carbohydrate metabolism, and explore whether the pathogenesis of idiopathic central precocious puberty (ICPP) and polycystic ovary syndrome (PCOS) is consistent based on GM. Methods In this study, we have recruited 27 ICPP (ICPP group) and 23 healthy children (healthy group), and collected the blood and fecal samples from the participants. Blood samples were tested for hormones, including the follicle-stimulating hormone, luteinizing hormone, estradiol, prolactin, and testosterone. DNA was extracted from fecal samples, and amplified and sequenced with 16S rDNA V3-V4 region. Finally, we annotated the sequencing results, counted the differences in hormone indicators and GM composition between the two groups, and analyzed the correlation with clinical indicators. At the same time, we reviewed the literature on GM and PCOS. Results Compared with the healthy group, the ICPP group exhibited significantly higher levels of the hormone and other indicators (P < 0.05). At the phylum level, the ICPP group showed significantly enriched Proteobacteria than the healthy group (4.85% vs 2.92%). At the genus level, the abundances of Roseburia and Prevotella were significantly higher in the ICPP group than those in the healthy group (7.55% vs 2.01%, 3.95% vs 0.19%), but Bacteroides were obviously decreased in the ICPP group (29.96% vs 44.91%). In addition, the potential associations underlying the sex hormonal secretion and the carbohydrate metabolism pathways of GM increased significantly in the ICPP group. Conclusion The alternations of GM in ICPP patients are closely related to carbohydrate metabolism, hyperandrogenism, and insulin resistance, indicating similar pathogenesis with polycystic ovary syndrome.

Prevalence of polycystic ovary syndrome in young women who had idiopathic central precocious puberty

2010 ◽  
Vol 93 (4) ◽  
pp. 1185-1191 ◽  
Author(s):  
Roberto Franceschi ◽  
Rossella Gaudino ◽  
Alma Marcolongo ◽  
Maria Chiara Gallo ◽  
Luigi Rossi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Young Women ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Ovary Syndrome ◽  
Idiopathic Central Precocious Puberty

scholarly journals Adipokine levels and carbohydrate metabolism in patients diagnosed de novo with polycystic ovary syndrome

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Ewelina Kolan′ska-Dams ◽  
Joanna Boinska ◽  
Maciej W. Socha
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Carbohydrate Metabolism ◽  
De Novo ◽  
Polycystic Ovary ◽  
Control Group ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Positive Correlation ◽  
Pcos Group

Introduction: Central obesity appears to play a major role in the pathogenesis of metabolic disorders in polycystic ovary syndrome. Insulin resistance and carbohydrate disorders are associated with dysfunctional secretion of various adipokines by the adipose tissue. Objectives: This study aimed to evaluate leptin, apelin, and visfatin against a background of carbohydrate metabolism parameters in patients diagnosed de novo with polycystic ovary syndrome (PCOS). Material and methods: The study group consisted of 40 patients with PCOS (mean age, 29 years) diagnosed in accordance with the American Society for Reproductive Medicine criteria from 2003. The control group consisted of 37 clinically healthy women (mean age, 26 years). All controls had regular menses and no clinical or biochemical signs of hyperandrogenism. Concentrations of leptin, apelin, visfatin, and insulin were measured by immunoenzymatic methods. Glucose concentrations were determined using spectrophotometry. Results: Significantly higher concentrations of leptin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR) index, and the immunoreactive insulin (IRI)/glucose index were found in the PCOS group than in the control group. Notably, the concentration of apelin was over five times lower in the PCOS group than in the control group. In patients with PCOS, a positive correlation was found between the concentrations of insulin and leptin and concentrations of leptin and IRI/glucose. Patients of the PCOS group with body mass index (BMI) ≥  25 had significantly higher values of leptin, insulin, HOMA-IR index, and IRI/glucose index than patients of the PCOS group with normal BMI. In the PCOS group, a positive correlation was found between BMI and leptin concentration (r = 0.7176; p < 0.0001) and carbohydrate metabolism, such as insulin (r = 0.5524; p = 0.0003), glucose (r = 0.3843; p = 0.0157), HOMA-IR (r = 0.5895; p < 0.0001), and IRI/glucose (r = 0.3872; p = 0.0163). These findings were not observed in the control group. Conclusions: (1) Increased leptin concentration observed in women diagnosed de novo with PCOS as well as positive correlations between leptin and HOMA-IR, and IRI/glucose and BMI may indicate a potential role of leptin in the reduction of tissue sensitivity to insulin. (2) Significantly lower apelin concentration in the PCOS group (>5 fold) than in the control group, associated with a concomitant increase in leptin, may also contribute to carbohydrate metabolism disorders occurring in the course of PCOS.

scholarly journals Gonadotropin releasing hormone analogue treatment of central precocious puberty is not associated with altered prevalence of polycystic ovary syndrome: a single center cohort study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Gilad Karavani ◽  
Henry H. Chill ◽  
Natali Schachter-Safrai ◽  
Gan Lomnitz ◽  
David Gillis ◽  
...  
Keyword(s):  
Cohort Study ◽  
Polycystic Ovary Syndrome ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Hormone Analogue ◽  
Ovary Syndrome ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Analogue

Abstract Background There is conflicting evidence regarding an association between gonadotropin releasing hormone analogue (GnRHa) therapy and polycystic ovary syndrome (PCOS). This study aimed to compare the prevalence of endocrine disorders, primarily PCOS, between women who had been treated with GnRHa for central precocious puberty (CPP) and those who were not treated. Methods This was a retrospective cohort study, including women diagnosed with central precocious puberty between 1989 and 2011 in a university affiliated tertiary medical center. Data collected included demographic data, medical background, clinical presentation at diagnosis and duration of treatment (zero for non-treated). Gynecologic and endocrine long-term outcomes were compared by treatment group. Results Fifty-one women were included in the study, 27/51 had been treated with gonadotropin releasing hormone analogue (GnRHa). Overall prevalence of PCOS was 19.6%. No statistically significant difference in prevalence of PCOS was demonstrated between the treated and non-treated groups. Similarly, overall prevalence of either clinical or laboratory hyper-androgenism, was 29.4% and 33.3%, for the treatment and non-treatment groups respectively (p = non-significant). Conclusions GnRHa treatment for precocious puberty is not associated with increased risk of polycystic ovary syndrome.

scholarly journals A 9-Year-Old Girl Presenting Central Precocious Puberty with Polycystic Ovary Syndrome

2002 ◽  
Vol 11 (2) ◽  
pp. 77-86
Author(s):  
Kanshi Minamitani ◽  
Hiromichi Nakajima ◽  
Akira Hoshioka ◽  
Kazuto Tamai ◽  
Tomomichi Kurosaki ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Precocious Puberty ◽  
Polycystic Ovary ◽  
Central Precocious Puberty ◽  
Ovary Syndrome
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