Follicle number and size as predictors of pregnancy outcome in unexplained infertility couples treated with clomiphene citrate and intrauterine insemination

2014 ◽  
Vol 102 (3) ◽  
pp. e219
Author(s):  
G.M. Bareh ◽  
R.D. Robinson ◽  
H. Caddell ◽  
T. Falcone ◽  
R.R. Schenken
Keyword(s):  
Pregnancy Outcome ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Unexplained Infertility

A Randomized Clinical Trial to Evaluate Optimal Treatment for Unexplained Infertility

2021 ◽  
pp. 246-250
Author(s):  
Stephanie Rothenberg ◽  
Joseph Sanfilippo
Keyword(s):  
Ovulation Induction ◽  
Treatment Approach ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Additional Benefit ◽  
Multiple Gestation ◽  
Time To Pregnancy ◽  
Vitro Fertilization

The treatment of unexplained infertility has traditionally been comprised of a stepwise treatment approach, first with ovulation induction combined with intrauterine insemination (IUI) and then with in vitro fertilization (IVF). Ovulation induction is first attempted with clomiphene citrate, and, if unsuccessful, injectable gonadotropins are used. The value of ovulation induction with injectable gonadotropins in couples with unexplained infertility has been questioned, however, given the high risk of multiple gestation and the increasing efficacy of IVF. To address this, the FASTT trial randomized couples with unexplained infertility to a treatment arm that either included or omitted gonadotropin/IUI. They found that an accelerated treatment approach that involved 3 cycles of clomiphene citrate/IUI and then progressed immediately to IVF resulted in a decreased time to pregnancy compared to the group who underwent gonadotropin/IUI for 3 cycles, as well as decreased cost per live birth. Therefore, it was concluded that treatment of couples with unexplained infertility with gonadotropin/IUI was of no additional benefit.

Thin endometrial stripe does not affect pregnancy outcome in clomiphene citrate/intrauterine insemination cycles

2013 ◽  
Vol 100 (3) ◽  
pp. S77-S78
Author(s):  
A. Asante ◽  
Z. Khan ◽  
L.A. Schenck ◽  
J.R. Jensen ◽  
C.C. Coddington ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate

scholarly journals Pregnancy Predictors after Intrauterine Insemination in Cases of Unexplained Infertility: A Prospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Ishita Ganguly ◽  
Aparna Singh ◽  
Shilpa Bhandari ◽  
Pallavi Agrawal ◽  
Nitika Gupta
Keyword(s):  
Luteal Phase ◽  
Intrauterine Insemination ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Trimester Abortion ◽  
Follicle Diameter ◽  
Number Of Treatment ◽  
A Prospective Study ◽  
Singleton Pregnancies ◽  
Urine Pregnancy Test

Introduction. Aim of the study was to find the effect of various prognostic factors in cases of unexplained infertility undergoing controlled ovarian stimulation (COS) with intrauterine insemination (IUI).Methods. 146 cases of unexplained infertility were included. A maximum of 3 cycles of IUI were done with clomiphene citrate/HMG. Ovulation trigger was given when the largest follicle diameter was >18 mm, and IUI was planned 36 hours later. Luteal phase support was given for 15 days, urine pregnancy test was done on day 15, ultrasonography was done at 7 weeks, and pregnancy was followed up till delivery.Results. A total of 146 couples have undergone 239 cycles of IUI out of which 27 had UPT positive after 15 days. 14.8% had 1st-trimester abortion while 3.7% were ectopic. 86.3% were singleton pregnancies and 13.6% were twins. CPR was 11.29% per cycle and 18.4% per couple; LBR was 9.2% per cycle. Apart from duration of stimulation (p=0.037) and number of treatment cycles (p=0.045), no other factors had significant prognostic value.Conclusion. For unexplained infertility, IUI can be done to provide patients with the time that they need before moving on to IVF while providing a respectable chance of pregnancy.

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