Multiple pregnancy rates are lower when utilizing letrozole (LET) compared to clomiphene citrate (CC) for ovulation induction (OI) or controlled ovarian hyperstimulation (COH)

2014 ◽  
Vol 102 (3) ◽  
pp. e226
Author(s):  
J. Rodriguez-Purata ◽  
J.A. Lee ◽  
E. Cervantes ◽  
M. Luna ◽  
L. Grunfeld ◽  
...  
Keyword(s):  
Ovulation Induction ◽  
Clomiphene Citrate ◽  
Multiple Pregnancy ◽  
Controlled Ovarian Hyperstimulation ◽  
Pregnancy Rates ◽  
Ovarian Hyperstimulation

scholarly journals Comparison of different ovulation protocols in patients undergoing controlled ovulation hyperstimulation with intra uterine insemination

2018 ◽  
Vol 7 (8) ◽  
pp. 3039
Author(s):  
Shirly Kurian ◽  
Sarat Battina
Keyword(s):  
Intrauterine Insemination ◽  
Low Cost ◽  
Clomiphene Citrate ◽  
Multiple Pregnancy ◽  
Controlled Ovarian Hyperstimulation ◽  
Pregnancy Rates ◽  
Strong Impact ◽  
Follicle Diameter ◽  
Menstrual History ◽  
Intra Uterine Insemination

Background: For many couples’ advent of a baby is the most beautiful gift of life. Involuntary childlessness by itself does not threaten physical health but can have a strong impact on the psychological and social wellbeing of couples. The aim of the present investigation was comparison of different ovulation protocols in patients undergoing controlled ovulation hyperstimulation with Intra uterine insemination.Methods: A Prospective observational study was conducted in the department of obstetrics and gynaecology. 200 couples who underwent 541 cycles with controlled ovarian hyperstimulation. Variables selected for analysis were female age, menstrual history, duration of infertility, number of cycles, number dominant follicle diameter, endometrial thickness.Results: Maximum patients underwent ovulation induction with clomiphene citrate (202/541) and then with letrozole (202/541).Conclusions: Nowadays when the costs of health care are limited, intrauterine insemination can hold its place as a low-cost method of infertility treatment. Conclusively with careful selection of subjects, appropriate controlled ovarian stimulation and intra uterine insemination, good pregnancy rates with low multiple pregnancy rates can be achieved.

CLINICAL ANALYSIS OF CLOMIPHENE CITRATE INDUCED OVULATION IN INFERTILITY PATIENTS WITH POLYCYSTIC OVARIAN DISEASE

2021 ◽  
Vol 4 (5) ◽  
Author(s):  
Preeti Suhas Deshpande
Keyword(s):  
Pregnancy Rate ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Multiple Pregnancy ◽  
Follicular Development ◽  
Pregnancy Rates ◽  
Initial Assessment ◽  
Infertile Women ◽  
The Mean

Background: Normo-gonadotrophic anovulation is the most prevalent anovulatory infertility type. Polycystic ovary disease (PCOS) is by far the most common cause in this category, accounting for 85 % of females who are anovulatory. Its prevalence is growing increasingly with increasing modernisation. Ovulation induction in PCOS females is a problem and the best drug for ovulation induction is still debatable. Aims & objectives: In the current research, we evaluated the efficacy of clomiphene citrate in infertile women with polycystic ovary disease for ovulation induction and pregnancy rates. Material and Methods: The present research was a prospective study conducted with PCOS, willing to participate and follow up in women with primary/secondary infertility. Rotterdam criteria were used to diagnose PCOS. Using descriptive statistics, statistical analysis was performed. Results: Initially, 140 patients in the current study were recruited. For the current research, 128 patients either born or cared for a full 6 months were considered. 21-25 years of age was the most common age group. The mean age of the patients examined was 26.34 ± 3.6 years. 55 % were having average BMI patients, while 34% were overweight. Primary infertility was present in 77 percent of patients. 73 per cent of patients had infertility duration of 1-5 years. 30 percent have a history of laparoscopic ovarian drilling in patients. In 58 percent, hirsutism was noted. Following serial USG monitoring, mono-follicular development (55 %) was more prevalent than multi-follicular development at the end of the study (45 percent). The mean thickness of the endometrium was 7.78 ± 2.58 mm. The mean days for clomiphene citrate ovulation are 14.84 ± 3.46. Average P4 values on day 21 were 11.48 ± 6.44 ng/ml. At the end of the study, 66 % ovulation rate, 28 % pregnancy rate, and 2 % multiple pregnancy incidence were noted. Conclusion: Ovulation induction with clomiphene citrate should be considered as the first line of treatment for infertile women with PCOS. Initial assessment and careful selection of patients increases pregnancy rates. Keywords: ovulation induction, polycystic ovary disease, clomiphene citrate, pregnancy rate.

scholarly journals The Use of High Dose Letrozole in Ovulation Induction and Controlled Ovarian Hyperstimulation

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Elizabeth A. Pritts ◽  
Alexander K. Yuen ◽  
Shefaali Sharma ◽  
Robert Genisot ◽  
David L. Olive
Keyword(s):  
Ovulation Induction ◽  
Detrimental Effect ◽  
Endometrial Thickness ◽  
Controlled Ovarian Hyperstimulation ◽  
High Dose ◽  
Ovarian Hyperstimulation ◽  
Dose Administration ◽  
Treatment Groups ◽  
Starting Dose ◽  
Higher Doses

Letrozole, an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent. However, dose administration has generally been limited to 5 days at 2.5 to 7.5 mg daily. We undertook a retrospective review of over 900 treatment cycles using letrozole in doses as high as 12.5 mg per day. Results indicate that such doses do indeed offer benefit to patients; in that there is increased follicular growth and a higher number of predicted ovulations with higher doses of the drug. However, increasing doses does not produce a detrimental effect upon endometrial thickness. High-dose letrozole may be of value in women who fail to respond adequately to lower doses. Furthermore, randomized trials are needed to determine whether high-dose letrozole might actually be optimal as a starting dose for certain treatment groups.

Effect of Controlled Ovarian Hyperstimulation on Pregnancy Rates After Intrauterine Insemination

1992 ◽  
Vol 47 (11) ◽  
pp. 801-802
Author(s):  
SHEILA J. DIMARZO ◽  
JOSEPH F. KENNEDY ◽  
PHILIP E. YOUNG ◽  
STEPHEN A. HEBERT ◽  
DIANNE C. ROSENBERG ◽  
...  
Keyword(s):  
Intrauterine Insemination ◽  
Controlled Ovarian Hyperstimulation ◽  
Pregnancy Rates ◽  
Ovarian Hyperstimulation

scholarly journals A Review of First Line Infertility Treatments and Supporting Evidence in Women with Polycystic Ovary Syndrome

2019 ◽  
Vol 7 (9) ◽  
pp. 95 ◽  
Author(s):  
Michael Costello ◽  
Rhonda Garad ◽  
Roger Hart ◽  
Hayden Homer ◽  
Louise Johnson ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Multiple Pregnancy ◽  
Reproductive Age ◽  
Supporting Evidence ◽  
First Line ◽  
Ovary Syndrome ◽  
Ultrasound Monitoring

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Lifestyle change is considered the first line treatment for the management of infertile anovulatory women with PCOS, and weight loss for those who are overweight or obese. First line medical ovulation induction therapy to improve fertility outcomes is letrozole, whilst other less efficacious ovulation induction agents, such as clomiphene citrate, metformin, and metformin combined with clomiphene citrate, may also be considered. Metformin combined with clomiphene citrate is more effective than clomiphene citrate alone. In obese women with PCOS, clomiphene citrate could be used in preference to metformin alone whilst clomiphene citrate could be added to metformin alone in order to improve reproductive outcome in all women with PCOS. Gonadotrophins, which are more effective than clomiphene citrate in therapy naïve women with PCOS, can be considered a first line therapy in the presence of ultrasound monitoring, following counselling on the cost and the potential risk of multiple pregnancy.

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