Addition of neither recombinant nor urinary luteinizing hormone was associated with an improvement in the outcome of autologous in vitro fertilization/intracytoplasmatic sperm injection cycles under regular clinical settings: a multicenter observational analysis

2016 ◽  
Vol 106 (7) ◽  
pp. 1714-1717.e1 ◽  
Author(s):  
Juan-Enrique Schwarze ◽  
Javier A. Crosby ◽  
Fernando Zegers-Hochschild
Keyword(s):  
In Vitro Fertilization ◽  
Luteinizing Hormone ◽  
Clinical Settings ◽  
Vitro Fertilization ◽  
Observational Analysis ◽  
Intracytoplasmatic Sperm Injection

Unstimulated in vitro fertilization revisited

1996 ◽  
Vol 5 (2) ◽  
pp. 129-138 ◽  
Author(s):  
Bradford Alan Kolb ◽  
Richard J Paulson
Keyword(s):  
In Vitro Fertilization ◽  
Luteinizing Hormone ◽  
Controlled Ovarian Hyperstimulation ◽  
Human Menopausal Gonadotropin ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Fertilization Rates ◽  
Oocyte Yield ◽  
Follicle Aspiration

The first attempts at in vitro fertilization (IVF) of human oocytes were performed during cycles utilizing human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG). These early cycles resulted in a successful conception, which unfortunately ended as a tubal gestation. The birth of Louise Brown in 1978, the first successful IVF birth, was actually achieved following fertilization during a spontaneous cycle in which ovulation was triggered with endogenous luteinizing hormone (LH).However, due to the greater margin for error afforded by larger numbers of follicles, the practice of IVF rapidly evolved towards the use of controlled ovarian hyperstimulation (COH) to achieve higher pregnancy rates. It is easy to understand why this approach evolved. Oocyte harvesting was accomplished primarily by laparoscopy. Since oocyte yield per follicle was less than 100% and fertilization rates were limited, the relatively traumatic follicle aspiration process was more likely to result in embryo transfer if a greater number of follicles was present.

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