scholarly journals DO ALL WOMEN AGED 43 AND OVER HAVE THE SAME CHANCE OF PREGNANCY USING AUTOLOGOUS OOCYTES WITH ART? WHICH PATIENTS HAVE A HIGHER CHANCE OF PREGNANCY?

2021 ◽  
Vol 116 (3) ◽  
pp. e391-e392
Author(s):  
Ipek Nur Balin Duzguner ◽  
Soner Duzguner ◽  
Beril Yuksel ◽  
Gönül Ozer ◽  
Semra Kahraman
Keyword(s):  
Autologous Oocytes

scholarly journals Rate of rebound in follicle growth after cessation of ovarian stimulation in initial non‐responders: a prospective cohort study

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Norbert Gleicher ◽  
Andrea Weghofer ◽  
Sarah K. Darmon ◽  
David H. Barad
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Ovarian Stimulation ◽  
Prospective Cohort ◽  
Follicle Growth ◽  
Gonadotropin Stimulation ◽  
Reported Study ◽  
Complete Failure ◽  
Incremental Step ◽  
Autologous Oocytes

AbstractPreviously anecdotally observed rebounds in follicle growth after interruption of exogenous gonadotropins in absolute non-responders were the impetus for here reported study. In a prospective cohort study, we investigated 49 consecutive patients, absolutely unresponsive to maximal exogenous gonadotropin stimulation, for a so-called rebound response to ovarian stimulation. A rebound response was defined as follicle growth following complete withdrawal of exogenous gonadotropin stimulation after complete failure to respond to maximal gonadotropin stimulation over up to 5–7 days. Median age of study patients was 40.5 ± 5.1 years (range 23–52). Women with and without rebound did not differ significantly (40.0 ± 6.0 vs. 41.0 ± 7.0 years, P = 0.41), with 24 (49.0%) recording a rebound and 25 (51.0%) not. Among the former, 21 (87.5%) reached retrieval of 1–3 oocytes and 15 (30.6%) reached embryo transfer. A successful rebound in almost half of prior non-responders was an unsuspected response rate, as was retrieval of 1–3 oocytes in over half of rebounding patients. Attempting rebounds may, thus, represent another incremental step in very poor prognosis patients before giving up on utilization of autologous oocytes. Here presented findings support further investigations into the underlying physiology leading to such an unexpectedly high rebound rate.

scholarly journals Sperm Selection by Magnetic-Activated Cell Sorting Before Microinjection of Autologous Oocytes Increases Cumulative Live Birth Rates with Limited Clinical Impact: A Retrospective Study in Unselected Males

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 430
Author(s):  
María Gil Juliá ◽  
Irene Hervás ◽  
Ana Navarro-Gómez Lechón ◽  
Fernando Quintana ◽  
David Amorós ◽  
...  
Keyword(s):  
Live Birth ◽  
Clinical Impact ◽  
Sperm Selection ◽  
Reproductive Outcomes ◽  
Birth Rates ◽  
Multicenter Observational Study ◽  
Live Birth Rates ◽  
Cumulative Live Birth ◽  
The Impact ◽  
Autologous Oocytes

The application of MACS non-apoptotic sperm selection in infertility clinics is controversial since the published literature does not agree on its effect on reproductive outcomes. Therefore, it is not part of the routine clinical practice. Classical measures of reproductive success (pregnancy or live birth rates per ovarian stimulation) introduce a bias in the evaluation of a technique’s effect, since only the best embryo is transferred. This retrospective, multicenter, observational study evaluated the impact of MACS on reproductive outcomes, measuring results in classical parameters and cumulative live birth rates (CLBR). Data from ICSI cycles using autologous oocyte in Spanish IVIRMA fertility clinics from January 2008 to February 2020 were divided into two groups according to their semen processing: standard practice (reference: 46,807 patients) versus an added MACS sperm selection (1779 patients). Only when measured as CLBR per embryo transferred and per MII oocyte used was the difference between groups statistically significant. There were no significant differences between MACS and reference groups on pregnancy and live birth rates. In conclusion, results suggest that non-apoptotic sperm selection by MACS on unselected males prior to ICSI with autologous oocytes has limited clinical impact, showing a subtle increase in CLBR per embryo transferred.

scholarly journals Is 45 years-of-age the cut-off for using autologous oocytes?

2018 ◽  
Vol 37 (2) ◽  
pp. 123-125 ◽  
Author(s):  
John L. Yovich ◽  
Michael J. Chapman ◽  
Kevin N. Keane ◽  
Julian Savulescu
Keyword(s):  
Autologous Oocytes

scholarly journals IVF in women over 42 years old: is using autologous oocytes a reasonable option?

2003 ◽  
Vol 80 ◽  
pp. 215
Author(s):  
Selen Hotamisligil ◽  
Ronald Carson ◽  
Isaac Glatstein ◽  
Samuel Pang ◽  
Patricia McShane
Keyword(s):  
Autologous Oocytes

Effect of the oocyte donor;s quality: cumulative livebirth rates (CLBR) in IVF cycles with donor sperm in ovum donation vs. autologous oocytes

2010 ◽  
Vol 94 (4) ◽  
pp. S262-S263
Author(s):  
C. Gonzalez-Ravina ◽  
A. Pacheco ◽  
A. Pellicer ◽  
D. Pabon ◽  
M. Fernandez-Sanchez ◽  
...  
Keyword(s):  
Ovum Donation ◽  
Donor Sperm ◽  
Oocyte Donor ◽  
Autologous Oocytes

scholarly journals Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

2019 ◽  
Vol 58 (4) ◽  
pp. 173-178
Author(s):  
Milan Reljič ◽  
Vida Gavrić Lovrec
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Live Birth ◽  
Predictive Factors ◽  
Live Birth Rate ◽  
Fertilization Success ◽  
Multivariate Logistic Regression Model ◽  
Vitro Fertilization ◽  
Autologous Oocytes

Abstract Background The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of age. Methods Authors conducted a retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles performed at the Department of Reproductive Medicine and Gynecologic Endocrinology, University Medical Centre Maribor, Slovenia between January 2006 and December 2015 in women aged 40 or more. The characteristics of patients and cycles were compared regarding live birth as the final outcome. Results A total of 1920 IVF/ICSI cycles with egg retrieval in women ≥40 years of age were performed leading to 1591 embryo transfers. The live birth rate per embryo transfer was 17.3% at 40, 11.6% at 41, 8.2% at 42, 7.9% at 43, 1.9% at 44 and 0.0% at ≥45 years of age. The multivariate logistic regression model showed that besides women’s age (OR 0.66, 95% CI: 0.55–0.78), the number of previous cycles (OR 0.88, 95% CI: 0.82–0.95), number of good quality embryos on day 2 (OR 1.19, 95% CI: 1.05-1.36), number of embryos transferred (OR 1.57, 95% CI: 1.19–2.07) and day 5 embryo transfer (OR 2.21, 95% CI: 1.37–3.55) were also independent prognostic factors for live birth. Conclusions The chance of in vitro fertilization success in women ≥40 years of age should not be estimated only on the woman’s age, but also on other predictive factors: number of previous cycles, number of good quality embryos on day 2, number of transferred embryos and blastocyst embry transfer.

scholarly journals Fertilization by ICSI generates a higher number of live births than IVF in a pioneer facility applying >90% single blastocyst-stage embryo transfers

2021 ◽  
Vol 15 (1) ◽  
pp. 087-103
Author(s):  
John L Yovich ◽  
Jason L Conceicao ◽  
Jesmine Wong ◽  
Nicole Marjanovich ◽  
Rachel Wicks ◽  
...  
Keyword(s):  
Treatment Cycle ◽  
Age Groups ◽  
Blastocyst Stage ◽  
Younger Women ◽  
Oocyte Fertilization ◽  
Retrospective Data Analysis ◽  
Stage Embryo ◽  
Poor Fertilization ◽  
Autologous Oocytes

Following earlier studies introducing an IVF-ICSI Split model on couples with unexplained infertility to avoid the scenario of unexplained failed or poor fertilization, PIVET has adopted a high ICSI rate approaching 90%, whereas the general rate among Australian facilities is around 60%. This observational study with retrospective data analysis reports on the IVF±ICSI procedures conducted over the period 2011 to 2019 with follow-up of ensuing pregnancies through 2020. Using autologous oocytes, 2343 women had 3434 IVF±ICSI cycles where 84.5% of women had 88.9% of initiated treatment cycles using ICSI and only 5.3% of women had 4.0% of cycles by IVF. The remaining 10.1% of women utilized the IVF-ICSI Split model for the remaining 7.2% of cycles. It was shown that oocyte fertilization rates were significantly higher for ICSI (p<0.0001), but not significant for women >40 years. The utilization rates of the ensuing embryos were ~45% across all ages with no significant differences across the ages, except for those small numbers of women ≥45 years who had a higher rate from IVF-generated embryos (p<0.0002). Pregnancy outcome were higher from ICSI-generated embryos across the age groups, being especially marked among the younger women <40 years (p<0.0001). Miscarriage rates were lowest for the IVF-generated pregnancies (overall 6.7% vs 22.8%, p<0.0001) but nevertheless the final live birth productivity rates per initiated treatment cycle remained higher from the ICSI-generated pregnancies (56.5% vs 46.3%; p<0.0001). Although this study does not meet the highest standards for EBM, it emanates from a pioneer facility with >40 years of published activity and which practices 90% blastocyst transfers in >90% SET cycles. The study supports a high ICSI rate of almost 90% and an IVF-ICSI Split rate of 10%.

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