LIVE BIRTH (LB) AND RACIAL DISPARITIES IN DONOR OOCYTE RECIPIENT CYCLES: A SART CORS ANALYSIS

Abstract STUDY QUESTION For donor oocyte recipients, are birth outcomes superior for fresh versus frozen embryos? SUMMARY ANSWER Among fresh donor oocyte recipients, fresh embryos are associated with better birth outcomes when compared with frozen embryos. WHAT IS KNOWN ALREADY Frozen embryo transfer (ET) with vitrification has been associated with improved pregnancy rates, but also increased rates of large for gestational age infants. Donor oocyte recipients represent an attractive biological model to attempt to isolate the impact of embryo cryopreservation on IVF outcomes, yet there is a paucity of studies in this population. STUDY DESIGN, SIZE, DURATION A retrospective cohort of the US national registry, the Society for Assisted Reproductive Technology Clinic Outcome Reporting System, of IVF cycles of women using fresh donor oocytes resulting in ET between 2013 and 2015. Thawed oocytes were excluded. PARTICIPANTS/MATERIALS, SETTINGS, METHODS Good obstetric outcome (GBO), defined as a singleton, term, live birth with appropriate for gestational age birth weight, was the primary outcome measure. Secondary outcomes included live birth, clinical pregnancy, spontaneous abortion, preterm birth, multiple births and gestational age-adjusted weight. Outcomes were modeled using the generalized estimating equation approach. MAIN RESULTS AND THE ROLE OF CHANCE Data are from 25 387 donor oocyte cycles, in which 14 289 were fresh and 11 098 were frozen ETs. A GBO was 27% more likely in fresh ETs (26.3%) compared to frozen (20.9%) (adjusted risk ratio 1.27; 95% confidence interval (CI) 1.21–1.35; P < 0.001). Overall, fresh transfer was more likely to result in a live birth (55.7% versus 39.5%; adjusted risk ratio 1.21; 95% CI 1.18–1.26; P < 0.001). Among singleton births, there was no difference in gestational age-adjusted birth weight between groups. LIMITATION, REASONS FOR CAUTION Our cohort findings contrast with data from autologous oocytes. Prospective studies with this population are warranted. WIDER IMPLICATIONS OF THE FINDINGS Among donor oocyte recipients, fresh ETs may be associated with better birth outcomes. Reassuringly, given its prevalent use, modern embryo cryopreservation does not appear to result in phenotypically larger infants. STUDY FUNDING/COMPETING INTEREST(S) None. TRIAL REGISTRATION NUMBER N/A.

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FRESH EMBRYO TRANSFER FOLLOWING IN VITRO INSEMINATION OF FRESH VERSUS CRYOPRESERVED ANONYMOUS DONOR OOCYTES- WHICH HAS A BETTER LIVE BIRTH RATE? A SART CORS ANALYSIS

Fertility and Sterility ◽

10.1016/j.fertnstert.2020.08.062 ◽

2020 ◽

Vol 114 (3) ◽

pp. e13

Author(s):

Rachel M. Whynott ◽

Karen M. Summers ◽

G. David Ball ◽

Bradley J. Van Voorhis ◽

Amy E. Sparks

Keyword(s):

Embryo Transfer ◽

Live Birth ◽

Birth Rate ◽

Live Birth Rate ◽

Fresh Embryo Transfer ◽

Donor Oocytes ◽

Sart Cors

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Likelihood of a singleton live birth from IVF treatment: analysis of 2004-13 first fresh cycles in the SART CORS

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.07.1015 ◽

2017 ◽

Vol 108 (3) ◽

pp. e346

Author(s):

B. Luke ◽

M.B. Brown ◽

E. Levens ◽

K. Doody ◽

B.J. Van Voorhis ◽

...

Keyword(s):

Live Birth ◽

Treatment Analysis ◽

Singleton Live Birth ◽

Sart Cors

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Racial disparities: in vitro fertilization (IVF) outcomes in donor oocyte recipients

Fertility and Sterility ◽

10.1016/j.fertnstert.2016.07.287 ◽

2016 ◽

Vol 106 (3) ◽

pp. e99

Author(s):

X. Zhou ◽

D. McQueen ◽

A. Schufreider ◽

M.L. Uhler ◽

E.C. Feinberg

Keyword(s):

In Vitro Fertilization ◽

Racial Disparities ◽

Vitro Fertilization ◽

Ivf Outcomes ◽

Donor Oocyte

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P–295 Does endometriosis affect oocyte quality? An analysis of 13 627 donor oocyte recipient and autologous IVF cycles

Human Reproduction ◽

10.1093/humrep/deab130.294 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

M S Kamath ◽

B Antonisamy ◽

S K Sunkara

Keyword(s):

Embryo Transfer ◽

Live Birth ◽

Study Design ◽

Oocyte Quality ◽

Pregnancy Rates ◽

Frozen Embryo Transfer ◽

In Vitro Fertilisation ◽

Donor Oocyte ◽

Human Fertilization ◽

Significant Difference

Abstract Study question Does endometriosis affect live birth following donor oocyte recipient versus autologous in vitro fertilisation (IVF) cycle. Summary answer There was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient versus autologous IVF cycle. What is known already For infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis when compared to tubal factor infertility. It has been debated that lower pregnancy rates following IVF in endometriosis is due to both oocyte quality and the endometrium. To delineate whether endometriosis affects oocyte quality or the endometrium, we planned a study using donor oocyte recipient model where the recipient were women with endometriosis. We compared the LBR after oocyte recipient cycle with autologous IVF in women with endometriosis Study design, size, duration We obtained anonymised dataset of all the IVF cycles performed in the UK since 19991 from the Human Fertilization and Embryology Authority (HFEA). Data from 1996 to 2016 comprising a total of 13 627 donor oocyte recipient and autologous IVF cycles with endometriosis and no other cause of infertility were analysed. Participants/materials, setting, methods Data on all women with endometriosis undergoing fresh or frozen IVF treatment cycles were analysed to compare the LBR between donor oocyte recipient and autologous treatment cycles. Logistic regression analysis was performed adjusting for number of previous IVF cycles, previous live birth, period of treatment, day of embryo transfer, number of embryo transferred, fresh and frozen cycle. Main results and the role of chance There was no significant difference in the LBR in women with endometriosis undergoing donor oocyte recipient fresh cycles compared to women undergoing fresh autologous IVF cycles (31.6% vs. 31.0%; odds ratio, OR 1.03, 99% CI 0.79 – 1.35). After adjusting for confounders listed above, there was no significant difference in LBR in women undergoing donor oocyte recipient fresh cycles versus fresh autologous ART cycles (aOR 1.06, 99% CI 0.79 – 1.42). There was no significant difference in the LBR in women with endometriosis undergoing frozen donor oocyte recipient cycles compared to women undergoing autologous frozen embryo transfer cycles (19.6% vs. 24.0%; OR 0.77, 99% CI 0.47 - 1.25). After adjusting for potential confounders, there was no significant difference in the LBR in women undergoing frozen donor oocyte recipient cycles compared with autologous frozen embryo transfer cycles (aOR 0.84, 99% CI 0.50 - 1.41). Limitations, reasons for caution Although the analysis was adjusted for several potential confounders, there was no information on classification of endometriosis to allow adjustment. Wider implications of the findings: The current study design does not indicate endometriosis has an impact on oocyte quality given that the outcomes in donor oocyte recipient cycles are comparable with autologous IVF cycles. These findings need to be further studied and validated. Trial registration number Not applicable

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AMH IS STRONGLY ASSOCIATED WITH CUMULATIVE LIVE BIRTH RATE INDEPENDENT OF AGE: AN ANALYSIS OF 132,466 CYCLES FROM THE SART-CORS DATABASE FOR 2014-2016

Fertility and Sterility ◽

10.1016/j.fertnstert.2021.07.119 ◽

2021 ◽

Vol 116 (3) ◽

pp. e41

Author(s):

Reshef Tal ◽

David B. Seifer ◽

Renana Tal ◽

Emily Granger ◽

Oded Tal

Keyword(s):

Live Birth ◽

Birth Rate ◽

Live Birth Rate ◽

Cumulative Live Birth Rate ◽

Cumulative Live Birth ◽

Sart Cors

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P-295 Does endometriosis affect oocyte quality? An analysis of 13 627 donor oocyte recipient and autologous IVF cycles

Human Reproduction ◽

10.1093/humrep/deab127.073 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

M S Kamath ◽

B Antonisamy ◽

S K Sunkara

Keyword(s):

Embryo Transfer ◽

Live Birth ◽

Study Design ◽

Oocyte Quality ◽

Pregnancy Rates ◽

Frozen Embryo Transfer ◽

In Vitro Fertilisation ◽

Donor Oocyte ◽

Human Fertilization ◽

Significant Difference

Abstract Study question Does endometriosis affect live birth following donor oocyte recipient versus autologous in vitro fertilisation (IVF) cycle. Summary answer There was no significant difference in the live birth rate (LBR) in women with endometriosis undergoing donor oocyte recipient versus autologous IVF cycle. What is known already For infertile women with endometriosis, IVF is often considered as a treatment option. Lower implantation and pregnancy rates have been observed following IVF in women with endometriosis when compared to tubal factor infertility. It has been debated that lower pregnancy rates following IVF in endometriosis is due to both oocyte quality and the endometrium. To delineate whether endometriosis affects oocyte quality or the endometrium, we planned a study using donor oocyte recipient model where the recipient were women with endometriosis. We compared the LBR after oocyte recipient cycle with autologous IVF in women with endometriosis Study design, size, duration We obtained anonymised dataset of all the IVF cycles performed in the UK since 19991 from the Human Fertilization and Embryology Authority (HFEA). Data from 1996 to 2016 comprising a total of 13 627 donor oocyte recipient and autologous IVF cycles with endometriosis and no other cause of infertility were analysed. Participants/materials, setting, methods Data on all women with endometriosis undergoing fresh or frozen IVF treatment cycles were analysed to compare the LBR between donor oocyte recipient and autologous treatment cycles. Logistic regression analysis was performed adjusting for number of previous IVF cycles, previous live birth, period of treatment, day of embryo transfer, number of embryo transferred, fresh and frozen cycle. Main results and the role of chance There was no significant difference in the LBR in women with endometriosis undergoing donor oocyte recipient fresh cycles compared to women undergoing fresh autologous IVF cycles (31.6% vs. 31.0%; odds ratio, OR 1.03, 99% CI 0.79 – 1.35). After adjusting for confounders listed above, there was no significant difference in LBR in women undergoing donor oocyte recipient fresh cycles versus fresh autologous ART cycles (aOR 1.06, 99% CI 0.79 – 1.42). There was no significant difference in the LBR in women with endometriosis undergoing frozen donor oocyte recipient cycles compared to women undergoing autologous frozen embryo transfer cycles (19.6% vs. 24.0%; OR 0.77, 99% CI 0.47 - 1.25). After adjusting for potential confounders, there was no significant difference in the LBR in women undergoing frozen donor oocyte recipient cycles compared with autologous frozen embryo transfer cycles (aOR 0.84, 99% CI 0.50 - 1.41). Limitations, reasons for caution Although the analysis was adjusted for several potential confounders, there was no information on classification of endometriosis to allow adjustment. Wider implications of the findings The current study design does not indicate endometriosis has an impact on oocyte quality given that the outcomes in donor oocyte recipient cycles are comparable with autologous IVF cycles. These findings need to be further studied and validated. Trial registration number Not applicable

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