scholarly journals The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca2+ channels in rat vascular smooth muscle cells

FEBS Open Bio ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Yutaro Kobayashi ◽  
Toshihiko Fukuda ◽  
Mitsuru Tanaka ◽  
Toshiro Matsui
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Voltage Dependent ◽  
Ca2 Channels

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats

2000 ◽  
Vol 278 (3) ◽  
pp. H714-H722 ◽  
Author(s):  
Rui Wang ◽  
Yuejin Wu ◽  
Guanghua Tang ◽  
Lingyun Wu ◽  
Salma Toma Hanna
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Vascular Complications ◽  
Muscle Cells ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
High Concentration ◽  
Voltage Dependent

Vascular complications of diabetes are associated with abnormal Ca2+ handling by vascular smooth muscle cells (SMCs) in which the alteration in L-type voltage-dependent Ca2+ channel (VDCC) currents may play an important role. In the present study, the characteristics of L-type VDCC currents in tail artery SMCs from streptozotocin-induced diabetic rats were examined. The densities, but not the voltage dependence, of L-type VDCC currents were reduced as diabetes progressed from 1 wk to 3 mo. The inhibitory effect of dibutyryl-cAMP on L-type VDCC currents was greater in diabetic SMCs than in age-matched control cells ( P < 0.01). Both the stimulatory effect of BAY K 8644 and the inhibitory effect of nifedipine on L-type VDCC currents were significantly enhanced in diabetic cells. The diabetes-related abnormalities in L-type VDCC currents were mimicked by culturing SMCs with a high concentration of glucose. Our results suggest that the properties of L-type VDCC in diabetic vascular SMCs were significantly altered, partially related to the increased L-type VDCC sensitivity to cAMP and hyperglycemia.

5-Hydroxytryptamine induces transient Ca2+ influx through Ni2+-insensitive Ca2+ channels in rat vascular smooth muscle cells

1999 ◽  
Vol 380 (2-3) ◽  
pp. 163-170 ◽  
Author(s):  
Masahiko Hirafuji ◽  
Fumito Kawahara ◽  
Takashi Ebihara ◽  
Akihiro Nezu ◽  
Akihiko Tanimura ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

scholarly journals Farnesol Inhibits L-type Ca2+Channels in Vascular Smooth Muscle Cells

1997 ◽  
Vol 272 (51) ◽  
pp. 32240-32246 ◽  
Author(s):  
Jean-Baptiste Roullet ◽  
Ulrich C. Luft ◽  
Hong Xue ◽  
Justin Chapman ◽  
Rostislav Bychkov ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

Direct Block of Ca2+ Channels by Calmidazolium in Cultured Vascular Smooth Muscle Cells

1999 ◽  
Vol 34 (4) ◽  
pp. 488-496 ◽  
Author(s):  
Masanori Sunagawa ◽  
Hisashi Yokoshiki ◽  
Takashi Seki ◽  
Mariko Nakamura ◽  
Patrick Laber ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ca2 Channels

scholarly journals Calcium channel current of vascular smooth muscle cells: extracellular protons modulate gating and single channel conductance.

1994 ◽  
Vol 103 (4) ◽  
pp. 665-678 ◽  
Author(s):  
U Klöckner ◽  
G Isenberg
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Single Channel ◽  
Muscle Cells ◽  
Surface Charges ◽  
Channel Conductance ◽  
Channel Current ◽  
Voltage Dependent

Modulation of L-type Ca2+ channel current by extracellular pH (pHo) was studied in vascular smooth muscle cells from bovine pial and porcine coronary arteries. Relative to pH 7.4, alkaline pH reversibly increased and acidic pH reduced ICa. The efficacy of pHo in modulating ICa was reduced when the concentration of the charge carrier was elevated ([Ca2+]o or [Ba2+]o varied between 2 and 110 mM). Analysis of whole cell and single Ca2+ channel currents suggested that more acidic pHo values shift the voltage-dependent gating (approximately 15 mV per pH-unit) and reduce the single Ca2+ channel conductance gCa due to screening of negative surface charges. pHo effects on gCa depended on the pipette [Ba2+] ([Ba2+]p), pK*, the pH providing 50% of saturating conductance, increased with [Ba2+]p according to pK* = 2.7-2.log ([Ba2+]p) suggesting that protons and Ba2+ ions complete for a binding site that modulates gCa. The above mechanisms are discussed in respect to their importance for Ca2+ influx and vasotonus.

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