An efficient, fast, and green procedure to quantify α- and β-acids and xanthohumol in hops and their derived products

Background: Sample preparation is one of the most challenging phases in pharmaceutical analysis, especially in biological matrices, affecting the whole analytical methodology. Objective: In this study, a new Ca(II)/Cu(II)/alginate/CuO nanoparticles hydrogel fiber (CCACHF) was synthesized through a simple, green procedure and applied for fiber micro solid phase extraction (FMSPE) of diazepam (DIZ) and oxazepam (OXZ) as model drugs prior to high-performance liquid chromatography-UV detection (HPLC-UV). Methods: Composition and morphology of the prepared fiber were characterized and the effect of main parameters on the fiber fabrication and extraction efficiency have been studied and optimized. Results: In optimal conditions, calibration curves were linear ranging between 0.1–500 µg L−1 with regression coefficients of 0.9938 and 0.9968. Limit of detection (LOD) (S/N=3) and limit of quantification (LOQ) (S/N=10) of the technique for DIZ and OXZ were 0.03 to 0.1 µg L−1. Within-day and between-day relative standard deviations (RSDs) for DIZ and OXZ were 6.0–12.5% and 3.3–9.4%, respectively. Conclusion: The fabricated adsorbent has been substantially employed to extraction of selected benzo-diazepines (BZDs) from human serum real specimens and the obtained recoveries were also satisfactory (82.1-109.7%).

Download Full-text

Green Procedure for the Synthesis of β-Nitro Sulfides by Michael Addition of Thiols to Nitroolefins

Synthetic Communications ◽

10.1080/00397910802431065 ◽

2009 ◽

Vol 39 (4) ◽

pp. 676-690 ◽

Cited By ~ 14

Author(s):

Xin-Ping Hui ◽

Chao Yin ◽

Jun Ma ◽

Peng-Fei Xu

Keyword(s):

Michael Addition ◽

Green Procedure

Download Full-text

A Simple and Green Procedure for the Synthesis of N-Benzylthioureas

Letters in Organic Chemistry ◽

10.2174/157017811797249281 ◽

2011 ◽

Vol 8 (8) ◽

pp. 540-544 ◽

Cited By ~ 12

Author(s):

Lucia C. de Sequeira Aguiar ◽

Gil M. Viana ◽

Marcus V. dos Santos Romualdo ◽

Marcio V. Costa ◽

Bruno S. Bonato

Keyword(s):

Green Procedure

Download Full-text

Cyclodextrins tethered with oligolactides – green synthesis and structural assessment

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.13.77 ◽

2017 ◽

Vol 13 ◽

pp. 779-792 ◽

Cited By ~ 3

Author(s):

Cristian Peptu ◽

Mihaela Balan-Porcarasu ◽

Alena Šišková ◽

Ľudovít Škultéty ◽

Jaroslav Mosnáček

Keyword(s):

Ring Opening ◽

Laser Desorption Ionization ◽

Oh Groups ◽

Soft Ionization ◽

Light Scattering Detection ◽

Synthetic Procedure ◽

Evaporative Light Scattering ◽

Green Procedure ◽

Methylene Group

Biodegradable oligolactide derivatives based on α-, β- and γ-cyclodextrins (CDs) were synthesized by a green procedure in which CDs play the role of both the initiator and the catalyst. The synthetic procedure in which CDs and L-lactide (L-LA) are reacting in bulk at relatively high temperature of 110 °C was investigated considering the structural composition of the products. The obtained products were thoroughly characterized via mass spectrometry methods with soft ionization like matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI). Liquid chromatography (LC) separation with evaporative light scattering detection (ELSD) and NMR analysis were employed in order to elucidate the structural profiles of the obtained mixtures. The results clearly demonstrate that the cyclodextrins were tethered with more than one short oligolactate chain per CD molecule, predominantly at the methylene group, through ring opening of L-LA initiated by primary OH groups.

Download Full-text