Improved freeze drying efficiency by ice nucleation proteins with ice morphology modification

2018 ◽  
Vol 106 ◽  
pp. 90-97 ◽  
Author(s):  
Jue Jin ◽  
Edward J. Yurkow ◽  
Derek Adler ◽  
Tung-Ching Lee
Keyword(s):  
Freeze Drying ◽  
Ice Nucleation ◽  
Morphology Modification ◽  
Drying Efficiency ◽  
Ice Morphology ◽  
Ice Nucleation Proteins

100% Control of Controlled Ice Nucleation Vials by Camera-Supported Optical Inspection in Freeze-Drying

2021 ◽  
pp. pdajpst.2020.012575
Author(s):  
Julian Hendryk Gitter ◽  
Raimund Geidobler ◽  
Werner Halbinger ◽  
Ingo Presser ◽  
Gerhard Winter
Keyword(s):  
Freeze Drying ◽  
Ice Nucleation ◽  
Optical Inspection

A Comparison of Controlled Ice Nucleation Techniques for Freeze-Drying of a Therapeutic Antibody

2018 ◽  
Vol 107 (11) ◽  
pp. 2748-2754 ◽  
Author(s):  
Julian H. Gitter ◽  
Raimund Geidobler ◽  
Ingo Presser ◽  
Gerhard Winter
Keyword(s):  
Freeze Drying ◽  
Ice Nucleation ◽  
Therapeutic Antibody

scholarly journals Ice morphology modification and solute recovery improvement by heating and annealing during block freeze-concentration of coffee extracts

2016 ◽  
Vol 189 ◽  
pp. 72-81 ◽  
Author(s):  
C.M. Robles ◽  
M.X. Quintanilla-Carvajal ◽  
F.L. Moreno ◽  
E. Hernández ◽  
M. Raventós ◽  
...  
Keyword(s):  
Freeze Concentration ◽  
Morphology Modification ◽  
Ice Morphology

scholarly journals Bacterial Ice Crystal Controlling Proteins

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-20 ◽  
Author(s):  
Janet S. H. Lorv ◽  
David R. Rose ◽  
Bernard R. Glick
Keyword(s):  
Freezing Tolerance ◽  
Crystal Surface ◽  
Molecular Size ◽  
Ice Nucleation ◽  
Ice Crystals ◽  
Ice Crystal ◽  
Freezing Damage ◽  
Ice Binding ◽  
Protein Classes ◽  
Ice Nucleation Proteins

Across the world, many ice active bacteria utilize ice crystal controlling proteins for aid in freezing tolerance at subzero temperatures. Ice crystal controlling proteins include both antifreeze and ice nucleation proteins. Antifreeze proteins minimize freezing damage by inhibiting growth of large ice crystals, while ice nucleation proteins induce formation of embryonic ice crystals. Although both protein classes have differing functions, these proteins use the same ice binding mechanisms. Rather than direct binding, it is probable that these protein classes create an ice surface prior to ice crystal surface adsorption. Function is differentiated by molecular size of the protein. This paper reviews the similar and different aspects of bacterial antifreeze and ice nucleation proteins, the role of these proteins in freezing tolerance, prevalence of these proteins in psychrophiles, and current mechanisms of protein-ice interactions.

Can Controlled Ice Nucleation Improve Freeze‐Drying of Highly‐Concentrated Protein Formulations?

2013 ◽  
Vol 102 (11) ◽  
pp. 3915-3919 ◽  
Author(s):  
Raimund Geidobler ◽  
Ilona Konrad ◽  
Gerhard Winter
Keyword(s):  
Freeze Drying ◽  
Ice Nucleation ◽  
Protein Formulations
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