Reactive Oxygen Species Generating Photosynthesized Ferromagnetic Iron Oxide Nanoparticle as Promising Anti-Leishmanial Agent

2018 ◽  
Vol 120 ◽  
pp. S47
Author(s):  
Akhtar Nadhman ◽  
Qurat-ul-Ain ◽  
Amna Munawar ◽  
Masoom Yasinzai
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Reactive Oxygen ◽  
Iron Oxide Nanoparticle ◽  
Oxygen Species ◽  
Oxide Nanoparticle ◽  
Ferromagnetic Iron

Iron oxide nanoparticle phytotoxicity to the aquatic plant Lemna minor: effect on reactive oxygen species (ROS) production and chlorophyll a/chlorophyll b ratio

2019 ◽  
Vol 26 (23) ◽  
pp. 24121-24131 ◽  
Author(s):  
Lilian Rodrigues Rosa Souza ◽  
Luís Eduardo Bernardes ◽  
Maike Felipe Santos Barbetta ◽  
Márcia Andreia Mesquita Silva da Veiga
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Aquatic Plant ◽  
Lemna Minor ◽  
Iron Oxide Nanoparticle ◽  
Minor Effect ◽  
Ros Production ◽  
Oxygen Species ◽  
Chlorophyll B ◽  
Oxide Nanoparticle

Reactive oxygen species generating photosynthesized ferromagnetic iron oxide nanorods as promising antileishmanial agent

Nanomedicine ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. 755-771
Author(s):  
Arshad Islam ◽  
Quratul Ain ◽  
Amna Munawar ◽  
José Dias Corrêa Junior ◽  
Ajmal Khan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Therapeutic Potential ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
In Vivo Model ◽  
Oxygen Species ◽  
Oxide Nanorods ◽  
Ferromagnetic Iron

Aim: To investigate the photodynamic therapeutic potential of ferromagnetic iron oxide nanorods (FIONs), using Trigonella foenum-graecum as a reducing agent, against Leishmania tropica. Materials & methods: FIONs were characterized using ultraviolet visible spectroscopy, x-ray diffraction and scanning electron microscopy. Results: FIONs showed excellent activity against L. tropica promastigotes and amastigotes (IC50 0.036 ± 0.003 and 0.072 ± 0.001 μg/ml, respectively) upon 15 min pre-incubation light-emitting diode light (84 lm/W) exposure, resulting in reactive oxygen species generation and induction of cell death via apoptosis. FIONs were found to be highly biocompatible with human erythrocytes (LD50 779 ± 21 μg/ml) and significantly selective (selectivity index >1000) against murine peritoneal macrophages (CC50 102.7 ± 2.9 μg/ml). Conclusion: Due to their noteworthy in vitro antileishmanial properties, FIONs should be further investigated in an in vivo model of the disease.

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

Nano Letters ◽  
2017 ◽  
Vol 17 (2) ◽  
pp. 928-937 ◽  
Author(s):  
Ping’an Ma ◽  
Haihua Xiao ◽  
Chang Yu ◽  
Jianhua Liu ◽  
Ziyong Cheng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Iron Oxide ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

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