Loss of Protonmotive Force Activates the Mitochondrial Unfolded Protein Response, but does not regulate Mitochondrial Heteroplasmy

2020 ◽  
Vol 159 ◽  
pp. S71-S72
Author(s):  
Tyrone Nieves ◽  
Miao He ◽  
Brandon Berry ◽  
Andrew Wojtovich
Keyword(s):  
Unfolded Protein Response ◽  
Protonmotive Force ◽  
Unfolded Protein ◽  
Mitochondrial Heteroplasmy ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

scholarly journals At the heart of mitochondrial quality control: many roads to the top

2021 ◽  
Author(s):  
Roberta A. Gottlieb ◽  
Honit Piplani ◽  
Jon Sin ◽  
Savannah Sawaged ◽  
Syed M. Hamid ◽  
...  
Keyword(s):  
Quality Control ◽  
Unfolded Protein Response ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Dynamics ◽  
Mitochondrial Quality Control ◽  
Unfolded Protein ◽  
Selective Elimination ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

AbstractMitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.

scholarly journals The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

Cell ◽  
2018 ◽  
Vol 174 (4) ◽  
pp. 870-883.e17 ◽  
Author(s):  
Qian Zhang ◽  
Xueying Wu ◽  
Peng Chen ◽  
Limeng Liu ◽  
Nan Xin ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Unfolded Protein Response ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response
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