scholarly journals Identification of five mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Gene ◽  
2007 ◽  
Vol 395 (1-2) ◽  
pp. 98-107 ◽  
Author(s):  
Glenn A. Doyle ◽  
X. Rebecca Sheng ◽  
Sharon S.J. Lin ◽  
Danielle M. Press ◽  
Dorothy E. Grice ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor

Identification of three mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Gene ◽  
2007 ◽  
Vol 388 (1-2) ◽  
pp. 135-147 ◽  
Author(s):  
Glenn A. Doyle ◽  
X. Rebecca Sheng ◽  
Sharon S.J. Lin ◽  
Danielle M. Press ◽  
Dorothy E. Grice ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor

Promoter Region and Alternatively Spliced Exons of the Rat μ-Opioid Receptor Gene

2002 ◽  
Vol 66 (6) ◽  
pp. 2272-2278 ◽  
Author(s):  
P. Mayer ◽  
S. Schulzeck ◽  
J. Kraus ◽  
A. Zimprich ◽  
V. Höllt
Keyword(s):  
Opioid Receptor ◽  
Promoter Region ◽  
Receptor Gene ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor ◽  
Alternatively Spliced Exons

scholarly journals Differential expression of the alternatively spliced OPRM1 isoform μ-opioid receptor-1K in HIV-infected individuals

AIDS ◽  
2014 ◽  
Vol 28 (1) ◽  
pp. 19-30 ◽  
Author(s):  
Seth M. Dever ◽  
Blair N. Costin ◽  
Ruqiang Xu ◽  
Nazira El-Hage ◽  
Joyce Balinang ◽  
...  
Keyword(s):  
Differential Expression ◽  
Opioid Receptor ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor

scholarly journals Identification of the μ-opioid receptor splice variants involved in the lack of rewarding effect for amidino-TAPA

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-2-42
Author(s):  
Hirokazu Mizoguchi ◽  
Maya Yoshioka ◽  
Chizuko Watanabe ◽  
Akira Otowa ◽  
Shinobu Sakurada
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Rewarding Effect ◽  
Μ Opioid Receptor

Involvement of mouse μ-opioid receptor splice variants in the spinal antinociception induced by the dermorphin tetrapeptide analog amidino-TAPA

2011 ◽  
Vol 651 (1-3) ◽  
pp. 66-72 ◽  
Author(s):  
Hirokazu Mizoguchi ◽  
Chizuko Watanabe ◽  
Takayuki Higashiya ◽  
Satoshi Takeda ◽  
Kaori Moriyama ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Μ Opioid Receptor

Identification and Characterization of Three New Alternatively Spliced μ-Opioid Receptor Isoforms

1999 ◽  
Vol 56 (2) ◽  
pp. 396-403 ◽  
Author(s):  
Ying-Xian Pan ◽  
Jin Xu ◽  
Elizabeth Bolan ◽  
Catherine Abbadie ◽  
Albert Chang ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Isoforms ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor ◽  
Identification And Characterization

scholarly journals C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

2008 ◽  
Vol 104 (4) ◽  
pp. 937-945 ◽  
Author(s):  
Sue Oldfield ◽  
Ellen Braksator ◽  
Ivan Rodriguez-Martin ◽  
Chris P. Bailey ◽  
Lucy F. Donaldson ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Functional Characteristics ◽  
Μ Opioid Receptor

scholarly journals Stabilization of the μ-Opioid Receptor by Truncated Single Transmembrane Splice Variants through a Chaperone-like Action

2013 ◽  
Vol 288 (29) ◽  
pp. 21211-21227 ◽  
Author(s):  
Jin Xu ◽  
Ming Xu ◽  
Taylor Brown ◽  
Grace C. Rossi ◽  
Yasmin L. Hurd ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Opioid Receptor ◽  
Splice Variants ◽  
Receptor Gene ◽  
Exon Skipping ◽  
Receptor Expression ◽  
Functional Roles ◽  
Μ Opioid Receptor ◽  
Tm Domain

The μ-opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, as illustrated by the identification of an array of splice variants generated by both 5′ and 3′ alternative splicing. The current study reports the identification of another set of splice variants conserved across species that are generated through exon skipping or insertion that encodes proteins containing only a single transmembrane (TM) domain. Using a Tet-Off system, we demonstrated that the truncated single TM variants can dimerize with the full-length 7-TM μ-opioid receptor (MOR-1) in the endoplasmic reticulum, leading to increased expression of MOR-1 at the protein level by a chaperone-like function that minimizes endoplasmic reticulum-associated degradation. In vivo antisense studies suggested that the single TM variants play an important role in morphine analgesia, presumably through modulation of receptor expression levels. Our studies suggest the functional roles of truncated receptors in other G protein-coupled receptor families.

scholarly journals C-terminal Splice Variants of the Mouse μ-Opioid Receptor Differ in Morphine-induced Internalization and Receptor Resensitization

2001 ◽  
Vol 276 (33) ◽  
pp. 31408-31414 ◽  
Author(s):  
Thomas Koch ◽  
Stefan Schulz ◽  
Manuela Pfeiffer ◽  
Markus Klutzny ◽  
Helmut Schröder ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Μ Opioid Receptor
Sign in / Sign up

Export Citation Format

Share Document