scholarly journals Identification of the μ-opioid receptor splice variants involved in the lack of rewarding effect for amidino-TAPA

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-2-42
Author(s):  
Hirokazu Mizoguchi ◽  
Maya Yoshioka ◽  
Chizuko Watanabe ◽  
Akira Otowa ◽  
Shinobu Sakurada
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Rewarding Effect ◽  
Μ Opioid Receptor

Lack of a rewarding effect and a locomotor-enhancing effect of the selective μ-opioid receptor agonist amidino-TAPA

2010 ◽  
Vol 212 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Hirokazu Mizoguchi ◽  
Chizuko Watanabe ◽  
Shin Osada ◽  
Maya Yoshioka ◽  
Yuta Aoki ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Rewarding Effect ◽  
Enhancing Effect ◽  
Opioid Receptor Agonist ◽  
Μ Opioid Receptor

scholarly journals Identification of five mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Gene ◽  
2007 ◽  
Vol 395 (1-2) ◽  
pp. 98-107 ◽  
Author(s):  
Glenn A. Doyle ◽  
X. Rebecca Sheng ◽  
Sharon S.J. Lin ◽  
Danielle M. Press ◽  
Dorothy E. Grice ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor

Involvement of mouse μ-opioid receptor splice variants in the spinal antinociception induced by the dermorphin tetrapeptide analog amidino-TAPA

2011 ◽  
Vol 651 (1-3) ◽  
pp. 66-72 ◽  
Author(s):  
Hirokazu Mizoguchi ◽  
Chizuko Watanabe ◽  
Takayuki Higashiya ◽  
Satoshi Takeda ◽  
Kaori Moriyama ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Μ Opioid Receptor

scholarly journals C-terminal splice variants of the μ-opioid receptor: existence, distribution and functional characteristics

2008 ◽  
Vol 104 (4) ◽  
pp. 937-945 ◽  
Author(s):  
Sue Oldfield ◽  
Ellen Braksator ◽  
Ivan Rodriguez-Martin ◽  
Chris P. Bailey ◽  
Lucy F. Donaldson ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Functional Characteristics ◽  
Μ Opioid Receptor

Identification of three mouse μ-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon

Gene ◽  
2007 ◽  
Vol 388 (1-2) ◽  
pp. 135-147 ◽  
Author(s):  
Glenn A. Doyle ◽  
X. Rebecca Sheng ◽  
Sharon S.J. Lin ◽  
Danielle M. Press ◽  
Dorothy E. Grice ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Alternatively Spliced ◽  
Μ Opioid Receptor

scholarly journals Stabilization of the μ-Opioid Receptor by Truncated Single Transmembrane Splice Variants through a Chaperone-like Action

2013 ◽  
Vol 288 (29) ◽  
pp. 21211-21227 ◽  
Author(s):  
Jin Xu ◽  
Ming Xu ◽  
Taylor Brown ◽  
Grace C. Rossi ◽  
Yasmin L. Hurd ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Opioid Receptor ◽  
Splice Variants ◽  
Receptor Gene ◽  
Exon Skipping ◽  
Receptor Expression ◽  
Functional Roles ◽  
Μ Opioid Receptor ◽  
Tm Domain

The μ-opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, as illustrated by the identification of an array of splice variants generated by both 5′ and 3′ alternative splicing. The current study reports the identification of another set of splice variants conserved across species that are generated through exon skipping or insertion that encodes proteins containing only a single transmembrane (TM) domain. Using a Tet-Off system, we demonstrated that the truncated single TM variants can dimerize with the full-length 7-TM μ-opioid receptor (MOR-1) in the endoplasmic reticulum, leading to increased expression of MOR-1 at the protein level by a chaperone-like function that minimizes endoplasmic reticulum-associated degradation. In vivo antisense studies suggested that the single TM variants play an important role in morphine analgesia, presumably through modulation of receptor expression levels. Our studies suggest the functional roles of truncated receptors in other G protein-coupled receptor families.

scholarly journals C-terminal Splice Variants of the Mouse μ-Opioid Receptor Differ in Morphine-induced Internalization and Receptor Resensitization

2001 ◽  
Vol 276 (33) ◽  
pp. 31408-31414 ◽  
Author(s):  
Thomas Koch ◽  
Stefan Schulz ◽  
Manuela Pfeiffer ◽  
Markus Klutzny ◽  
Helmut Schröder ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Μ Opioid Receptor

Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics

2020 ◽  
Vol 20 (31) ◽  
pp. 2866-2877
Author(s):  
Hirokazu Mizoguchi ◽  
Hideaki Fujii
Keyword(s):  
Side Effects ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Splice Variants ◽  
Receptor Gene ◽  
Molecular Target ◽  
Μ Opioid Receptor ◽  
Dependence Liability ◽  
Μ Opioid Receptors

Since a μ-opioid receptor gene containing multiple exons has been identified, the variety of splice variants for μ-opioid receptors have been reported in various species. Amidino-TAPA and IBNtxA have been discovered as new analgesics with different pharmacological profiles from morphine. These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly, these analgesics show the selectivity to the morphine-insensitive μ-opioid receptor splice variants. The splice variants, sensitive to these new analgesics but insensitive to morphine, may be a better molecular target to develop the analgesics without side effects.

Identification of Four Novel Exon 5 Splice Variants of the Mouse μ-Opioid Receptor Gene: Functional Consequences of C-Terminal Splicing

2005 ◽  
Vol 68 (3) ◽  
pp. 866-875 ◽  
Author(s):  
Ying-Xian Pan ◽  
Jin Xu ◽  
Elizabeth Bolan ◽  
Howard S. Moskowitz ◽  
Mingming Xu ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Splice Variants ◽  
Receptor Gene ◽  
Functional Consequences ◽  
Μ Opioid Receptor ◽  
Novel Exon
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