scholarly journals Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine

Gene ◽  
2021 ◽  
pp. 145752
Author(s):  
Norihiro Okada ◽  
Kenshiro Oshima ◽  
Yuki Iwasaki ◽  
Akiko Maruko ◽  
Kenya Matsumura ◽  
...  
2020 ◽  
Author(s):  
Norihiro Okada ◽  
Kenshiro Oshima ◽  
Yuki Iwasaki ◽  
Akiko Maruko ◽  
Erica Iioka ◽  
...  

AbstractIntron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. Using klotho mice as a model, we proposed that retained introns are an excellent marker for the pre-disease state. Surprisingly, among widespread retained introns that accumulated during aging in the liver, a subset was recovered to the normal state by a Japanese traditional herbal medicine. IR-recovered genes fell into two categories: (1) those involved in the spliceosome and (2) those involved in liver-specific metabolism. By integrating data for splicing patterns, transcriptomes, and metabolomes, we hypothesize that this medicine-related IR recovery under the pre-disease state reflects the actual recovery of liver-specific function to the healthy state. Accordingly, the study provides proof-of-concept evidence related to the ancient Chinese statement proposing the medicine’s usefulness for treating the pre-disease state. This approach lays out a method for elucidating unknown molecular mechanisms of an herbal medicine with multiple ingredients.


2001 ◽  
Vol 120 (5) ◽  
pp. A248-A248
Author(s):  
N KAWASAKI ◽  
K NARIAI ◽  
M NAKAO ◽  
K NAKADA ◽  
N HANYUU ◽  
...  

2017 ◽  
Author(s):  
N Vahekeni ◽  
M Neto Pedro ◽  
K Kayimbo Malilo ◽  
P van Eeuwijk ◽  
P Mäser ◽  
...  
Keyword(s):  

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
H Orafai ◽  
AH Mohammadpor ◽  
E Avari ◽  
H Molaqen

2020 ◽  
Vol 1 (1) ◽  
pp. 47-58
Author(s):  
Khodijatul Qodriyah

The lack of students’ knowledge of their teachers’ works and the less of their consciousness to the environment are crucial problems in some islamic boardingschool, especially in Nurul Jadid. These issues will be settled by implementation of religious preaching (dakwah) with poem (syi’ir) in Syu’abul Iman of Kiai Zaini Mun’im and prefentive action to the illness through herbal medicines of family crops medicine (tanaman obat keluarga). The program is undertaken with some phases, including planting family crops medicine, making herbal medicines, musicalisation of poem in book of Syu’abul Iman, socialization of the herbal medicine and musical poem of Syu’abul Iman. These phases have been structured with long-term, middle-term, and short-term programs which were finished during approximately 4 months (Augustus – November 2019). The involvement of many parties, such as activists of environment in Nurul Jadid, has strongly influenced on the successful implementation of these programs.Keywords: Family Crops Medicine, Nurul Jadid Islamic Boardingschool, Book of Syu’abul Iman


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