The results of 205 puncture biopsies of solid and cystic pancreatic lesions performed in 202 patients at the Republican Oncological Dispensary of the Republic of Karelia for a 7-year period (2009-2015) are presented. Informative material for morphological investigation was obtained in 95.5% of cases. A comparison of results of cytological examination of the material from 56 patients with pancreatic lesions with histological data was carried out. The efficiency of the cytological method was 90.6%, sensitivity - 87.8%, specificity - 100%. To determine histological form of tumor in cytological examination of the material of the pancreas was successful in 82.1% of cases.