432 WITHDRAWN:Â Very Low Birth Weight is Associated With Reduced Right Ventricular Strain in Early Adulthood – Findings From a Cohort Study

Background: To evaluate the efficacy of Gastric Residual Volume (GRV) as a measure of feed intolerance /Necrotising enterocolitis in Very Low Birth Weight (VLBW) infants.Methods: This prospective observational cohort study was done in a tertiary care hospital located in rural South India for a period of 2 years. All haemodynamically stable infants born between 30-34 weeks of gestation at birth and 1000-1500 grams of birth weight, admitted to Neonatal Intensive Care Unit (NICU) within first 24 hours of life during study period were enrolled in two groups; GRV group, where pre-feed gastric residual volume was checked and No-GRV group, where pre-feed gastric residual volume was not checked.Results: Both groups had similar baseline characteristics. In No-GRV group, the days to reach birth weight (12.1) and days to attain full feeds (8.0) were less when compared to GRV group. In No-GRV group, average duration of NICU stay in days (16.60) and parenteral nutrition (5.25) was less when compared to GRV group. No-GRV group does not have increased incidence of sepsis or mortality compared to GRV group. In this study there was increased incidence of NEC noted in GRV group (30%) when compared to No-GRV group (p value-0.02).Conclusions: In hemodynamically stable preterm VLBW infants, it is recommended not to check gastric residual volume routinely prior to the enteral feeding.

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Reduced Exercise Capacity in Adults Born Very Low Birth Weight: A Population-Based Cohort Study

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.202103-0755oc ◽

2021 ◽

Author(s):

Jun Yang ◽

Michael J. Epton ◽

Sarah L Harris ◽

John Horwood ◽

Rachel A Kingsford ◽

...

Keyword(s):

Cohort Study ◽

Birth Weight ◽

Low Birth Weight ◽

Exercise Capacity ◽

Very Low Birth Weight ◽

Population Based

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Questioning the adequacy of standardized vitamin D supplementation protocol in very low birth weight infants: a prospective cohort study

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2021-0390 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Hatice Sarıdemir ◽

Ozge Surmeli Onay ◽

Ozge Aydemir ◽

Ayse Neslihan Tekin

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Birth Weight ◽

Low Birth Weight ◽

Prospective Cohort ◽

Very Low Birth Weight ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Vlbw Infants ◽

Vitamin D Levels

Abstract Objectives Preterm infants are at increased risk for vitamin D deficiency (VDD). We aimed to assess the adequacy of standardized vitamin D supplementation protocol in very low birth weight (VLBW) infants. Additionally, vitamin D status of mother/infant couples and the associations between vitamin D status at birth and morbidities of the infants were investigated. Methods In this single-center, prospective cohort study blood samples were collected from 55 mothers just before delivery and from their infants at birth and on the 30th day of life (DOL) for 25 hydroxy vitamin D (25OHD) measurements. Vitamin D was initiated in dose of 160 IU/kg by parenteral nutrition on the first DOL and oral vitamin D supplementation (400 IU/day) was administered when enteral feedings reached 50% of total intake or on the 15th DOL. Results The median 25OHD levels of the infants were 16.12 (9.14–20.50) in cord blood and 36.32 (31.10–44.44) in venous blood on the 30th DOL (p<0.01). In 98% of the VLBW infants 25OHD reached sufficient levels on the 30th DOL. None of the mothers had sufficient vitamin D levels (25OHD >30 ng/mL). Maternal 25OHD levels were correlated with the 25OHD levels of the infants in cord blood (r=0.665, p<0.001). There was a significant difference in mean cord 25OHD levels between winter (13.65 ± 5.69 ng/mL) and summer seasons (19.58 ± 11.67 ng/mL) (p=0.021). No association was found between neonatal morbidity and vitamin D status. Conclusions The results clearly show that by utilizing the current supplementation protocol, the majority of VLBW infants with deficient/insufficient serum 25OHD levels reached sufficient levels on the 30th DOL. Furthermore, vitamin D levels in mother/infant couples were found to be highly correlated.

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