Suppression mechanisms of high frequency electrical stimulation on seizure-like events in rat hippocampal microelectrode array recordings

Beta (β)- and gamma (γ)-oscillations are present in different cortical areas and are thought to be inhibition-driven, but it is not known if these properties also apply to γ-oscillations in humans. Here, we analyze such oscillations in high-density microelectrode array recordings in human and monkey during the wake–sleep cycle. In these recordings, units were classified as excitatory and inhibitory cells. We find that γ-oscillations in human and β-oscillations in monkey are characterized by a strong implication of inhibitory neurons, both in terms of their firing rate and their phasic firing with the oscillation cycle. The β- and γ-waves systematically propagate across the array, with similar velocities, during both wake and sleep. However, only in slow-wave sleep (SWS) β- and γ-oscillations are associated with highly coherent and functional interactions across several millimeters of the neocortex. This interaction is specifically pronounced between inhibitory cells. These results suggest that inhibitory cells are dominantly involved in the genesis of β- and γ-oscillations, as well as in the organization of their large-scale coherence in the awake and sleeping brain. The highest oscillation coherence found during SWS suggests that fast oscillations implement a highly coherent reactivation of wake patterns that may support memory consolidation during SWS.

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Results of long-term high frequency gastric electrical stimulation (GES) for treatment of gastroparesis refractory to standard medical therapy

Gastroenterology ◽

10.1016/s0016-5085(01)80480-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A98-A98 ◽

Cited By ~ 1

Author(s):

R MCCALLUM ◽

T ABELL ◽

M HOCKING ◽

K KOCH ◽

H ABRAHAMSSON ◽

...

Keyword(s):

Electrical Stimulation ◽

Medical Therapy ◽

High Frequency ◽

Gastric Electrical Stimulation ◽

Standard Medical Therapy

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Faculty Opinions recommendation of Value of electrical stimulation and high frequency oscillations (80-500 Hz) in identifying epileptogenic areas during intracranial EEG recordings.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3024973.2703077 ◽

2010 ◽

Author(s):

Roderick Duncan

Keyword(s):

Electrical Stimulation ◽

High Frequency ◽

Intracranial Eeg ◽

High Frequency Oscillations ◽

Eeg Recordings

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Deep Brain Stimulation of the Posterior Insula in Chronic Pain: A Theoretical Framework

Brain Sciences ◽

10.3390/brainsci11050639 ◽

2021 ◽

Vol 11 (5) ◽

pp. 639

Author(s):

David Bergeron ◽

Sami Obaid ◽

Marie-Pierre Fournier-Gosselin ◽

Alain Bouthillier ◽

Dang Khoa Nguyen

Keyword(s):

Chronic Pain ◽

Electrical Stimulation ◽

Deep Brain Stimulation ◽

Brain Stimulation ◽

High Frequency ◽

Brain Lesion ◽

Low Frequency ◽

Posterior Insula ◽

Deep Brain ◽

Stimulation Of

Introduction: To date, clinical trials of deep brain stimulation (DBS) for refractory chronic pain have yielded unsatisfying results. Recent evidence suggests that the posterior insula may represent a promising DBS target for this indication. Methods: We present a narrative review highlighting the theoretical basis of posterior insula DBS in patients with chronic pain. Results: Neuroanatomical studies identified the posterior insula as an important cortical relay center for pain and interoception. Intracranial neuronal recordings showed that the earliest response to painful laser stimulation occurs in the posterior insula. The posterior insula is one of the only regions in the brain whose low-frequency electrical stimulation can elicit painful sensations. Most chronic pain syndromes, such as fibromyalgia, had abnormal functional connectivity of the posterior insula on functional imaging. Finally, preliminary results indicated that high-frequency electrical stimulation of the posterior insula can acutely increase pain thresholds. Conclusion: In light of the converging evidence from neuroanatomical, brain lesion, neuroimaging, and intracranial recording and stimulation as well as non-invasive stimulation studies, it appears that the insula is a critical hub for central integration and processing of painful stimuli, whose high-frequency electrical stimulation has the potential to relieve patients from the sensory and affective burden of chronic pain.

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Modulation of torque evoked by wide-pulse, high-frequency neuromuscular electrical stimulation and the potential implications for rehabilitation and training

Scientific Reports ◽

10.1038/s41598-021-85645-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chris Donnelly ◽

Jonathan Stegmüller ◽

Anthony J. Blazevich ◽

Fabienne Crettaz von Roten ◽

Bengt Kayser ◽

...

Keyword(s):

Electrical Stimulation ◽

High Frequency ◽

Neuromuscular Electrical Stimulation ◽

Motor Units ◽

Progressive Increase ◽

Great Promise ◽

Measured Parameter ◽

Time Integral ◽

Spinal Circuitry ◽

Evoked Force

AbstractThe effectiveness of neuromuscular electrical stimulation (NMES) for rehabilitation is proportional to the evoked torque. The progressive increase in torque (extra torque) that may develop in response to low intensity wide-pulse high-frequency (WPHF) NMES holds great promise for rehabilitation as it overcomes the main limitation of NMES, namely discomfort. WPHF NMES extra torque is thought to result from reflexively recruited motor units at the spinal level. However, whether WPHF NMES evoked force can be modulated is unknown. Therefore, we examined the effect of two interventions known to change the state of spinal circuitry in opposite ways on evoked torque and motor unit recruitment by WPHF NMES. The interventions were high-frequency transcutaneous electrical nerve stimulation (TENS) and anodal transcutaneous spinal direct current stimulation (tsDCS). We show that TENS performed before a bout of WPHF NMES results in lower evoked torque (median change in torque time-integral: − 56%) indicating that WPHF NMES-evoked torque might be modulated. In contrast, the anodal tsDCS protocol used had no effect on any measured parameter. Our results demonstrate that WPHF NMES extra torque can be modulated and although the TENS intervention blunted extra torque production, the finding that central contribution to WPHF NMES-evoked torques can be modulated opens new avenues for designing interventions to enhance WPHF NMES.

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