Novel platinum complexes as efficient G-quadruplex DNA binders and telomerase inhibitors

2013 ◽  
Vol 55 ◽  
pp. 185-192 ◽  
Author(s):  
Chunying Wei ◽  
Ye Wen ◽  
Junhong Wang
Keyword(s):  
Platinum Complexes ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
G Quadruplex ◽  
Dna Binders

Antitumor substitution-inert polynuclear platinum complexes stabilize G-quadruplex DNA and suppress G-quadruplex-mediated gene expression

2021 ◽  
Author(s):  
Jaroslav Malina ◽  
Hana Kostrhunova ◽  
Nicholas Patrick Farrell ◽  
Viktor Brabec
Keyword(s):  
Gene Expression ◽  
Drug Targets ◽  
Platinum Complexes ◽  
Anticancer Therapy ◽  
Promoter Regions ◽  
Quadruplex Dna ◽  
G Quadruplex

DNA G-quadruplex (G4) structures formed in the telomeric and promoter regions represent attractive drug targets for anticancer therapy. Thus, much effort has been devoted to the development of a variety...

New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

2015 ◽  
Vol 13 (30) ◽  
pp. 8335-8348 ◽  
Author(s):  
Basudeb Maji ◽  
Krishan Kumar ◽  
K. Muniyappa ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Binding ◽  
Inhibition Activity ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
Mixed Ligands ◽  
G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

Facile syntheses of disubstituted bis(vinylquinolinium)benzene derivatives as G-quadruplex DNA binders

Tetrahedron ◽  
2013 ◽  
Vol 69 (24) ◽  
pp. 4922-4932 ◽  
Author(s):  
Zhen-Quan Liu ◽  
Shi-Tian Zhuo ◽  
Jia-Heng Tan ◽  
Tian-Miao Ou ◽  
Ding Li ◽  
...  
Keyword(s):  
Benzene Derivatives ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binders

Targeting the KRAS oncogene: Synthesis, physicochemical and biological evaluation of novel G-Quadruplex DNA binders

2020 ◽  
Vol 149 ◽  
pp. 105337 ◽  
Author(s):  
Federica D'Aria ◽  
Vincenzo Maria D'Amore ◽  
Francesco Saverio Di Leva ◽  
Jussara Amato ◽  
Marco Caterino ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binders

Anticancer Activity of Platinum (II) Complex as G-Quadruplex DNA Binders

2013 ◽  
Vol 781-784 ◽  
pp. 1130-1133
Author(s):  
Qi Pin Qin ◽  
Yu Lan Li ◽  
Yan Cheng Liu ◽  
Xu Jian Luo
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Normal Cell ◽  
Cancer Cell Lines ◽  
Cytotoxic Activities ◽  
Binding Properties ◽  
Quadruplex Dna ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Dna Binders

A platinum (II) complex has been synthesized and characterized. The complex binding properties with G-quadruplex DNA and ds26 were examined by FID and CD spectroscopic methods. The results revealed that the platinum (II) complex can induce the antiparallel G-quadruplex structure of HTG21 conformation in the absence of added K+ with selectivity over other G-quadruplex DNA and duplex DNA. The cytotoxicity of the platinum (II) was screened against four cancer cell lines and normal cells of HL-7702 in comparison to cisplatin and it showed a higher activity than cisplatin, with inhibition rates ranging from (40.06±1.65)% to (89.47±1.14)%. Furthermore, the platinum (II) complex displayed lower cytotoxic activities to HL-7702 (normal cell) compared with the cancer cell lines.

51 Platinum(II) phenanthroimidazoles with “clicked” side chains as selective G-quadruplex DNA binders

2013 ◽  
Vol 31 (sup1) ◽  
pp. 31-32
Author(s):  
Katherine J. Castor ◽  
Johans Akhoury ◽  
Zhaomin Liu ◽  
Mark Hancock ◽  
Anthony Mittermaier ◽  
...  
Keyword(s):  
Side Chains ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binders

Phenanthroline polyazamacrocycles as G-quadruplex DNA binders

2018 ◽  
Vol 16 (15) ◽  
pp. 2776-2786 ◽  
Author(s):  
Josué Carvalho ◽  
Telma Quintela ◽  
Nassima M. Gueddouda ◽  
Anne Bourdoncle ◽  
Jean-Louis Mergny ◽  
...  
Keyword(s):  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binders

Several phenanthroline polyazamacrocycles are proposed as ligands for c-MYC and telomeric G-quadruplex structures.

Sign in / Sign up

Export Citation Format

Share Document