Platinum(II) Complexes with Dipyridophenazine Ligands as Human Telomerase Inhibitors and Luminescent Probes for G-Quadruplex DNA

2009 ◽  
Vol 131 (5) ◽  
pp. 1835-1846 ◽  
Author(s):  
Dik-Lung Ma ◽  
Chi-Ming Che ◽  
Siu-Cheong Yan
Keyword(s):  
Quadruplex Dna ◽  
Luminescent Probes ◽  
Telomerase Inhibitors ◽  
G Quadruplex ◽  
Human Telomerase

New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

2015 ◽  
Vol 13 (30) ◽  
pp. 8335-8348 ◽  
Author(s):  
Basudeb Maji ◽  
Krishan Kumar ◽  
K. Muniyappa ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Binding ◽  
Inhibition Activity ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
Mixed Ligands ◽  
G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

Structure-Based Design of Platinum(II) Complexes as c-myc Oncogene Down-Regulators and Luminescent Probes for G-Quadruplex DNA

2010 ◽  
Vol 16 (23) ◽  
pp. 6900-6911 ◽  
Author(s):  
Ping Wang ◽  
Chung-Hang Leung ◽  
Dik-Lung Ma ◽  
Siu-Cheong Yan ◽  
Chi-Ming Che
Keyword(s):  
Quadruplex Dna ◽  
Luminescent Probes ◽  
Myc Oncogene ◽  
G Quadruplex

Diiridium(iii) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging

2017 ◽  
Vol 41 (1) ◽  
pp. 377-386 ◽  
Author(s):  
Tikum Florence Anjong ◽  
Gyoungmi Kim ◽  
Ha Yoon Jang ◽  
Juyoung Yoon ◽  
Jinheung Kim
Keyword(s):  
Endoplasmic Reticulum ◽  
Quadruplex Dna ◽  
Luminescent Probes ◽  
G Quadruplex

Two new dinuclear iridium (Ir) complexes bridged by a conjugated aromatic tppz ligand, (bhq)2Ir(tppz)Ir(bhq)2(1) and (ppy)2Ir(tppz)Ir(ppy)2(2) (bhq = benzo(h)quinolone, ppy = phenyl-pyridine, tppz = tetrapyrido[3,2-a:2′,3′-c:3′′,2′′-h:2′′′,3′′′-j]phenazine), were prepared.

Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: A new class of telomerase inhibitors

2007 ◽  
Vol 15 (4) ◽  
pp. 1848-1858 ◽  
Author(s):  
Marco Franceschin ◽  
Antonello Alvino ◽  
Valentina Casagrande ◽  
Clementina Mauriello ◽  
Emanuela Pascucci ◽  
...  
Keyword(s):  
Specific Interactions ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
New Class ◽  
Telomerase Inhibitors ◽  
G Quadruplex

scholarly journals Correction: Diiridium(iii) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging

2017 ◽  
Vol 41 (10) ◽  
pp. 4241-4241
Author(s):  
Tikum Florence Anjong ◽  
Gyoungmi Kim ◽  
Ha Yoon Jang ◽  
Juyoung Yoon ◽  
Jinheung Kim
Keyword(s):  
Endoplasmic Reticulum ◽  
Quadruplex Dna ◽  
Luminescent Probes ◽  
G Quadruplex

Correction for ‘Diiridium(iii) complexes: luminescent probes and sensors for G-quadruplex DNA and endoplasmic reticulum imaging’ by Tikum Florence Anjong et al., New J. Chem., 2017, 41, 377–386.

Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators

2020 ◽  
Vol 27 (1) ◽  
pp. 154-169 ◽  
Author(s):  
Claudiu N. Lungu ◽  
Bogdan Ionel Bratanovici ◽  
Maria Mirabela Grigore ◽  
Vasilichia Antoci ◽  
Ionel I. Mangalagiu
Keyword(s):  
Experimental Data ◽  
Antimicrobial Properties ◽  
Qsar Model ◽  
Therapeutic Effectiveness ◽  
Computational Results ◽  
Pyridine Derivatives ◽  
Quadruplex Dna ◽  
Dna Intercalators ◽  
Structure Activity ◽  
G Quadruplex

Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex
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