A bioactive polypeptide from sugarcane selectively inhibits intestinal sucrase

2020 ◽  
Vol 156 ◽  
pp. 938-948
Author(s):  
Shaik Abduldileep ◽  
Raja Narayanasamy ◽  
Dandamudi Usharani ◽  
Ajeet Singh ◽  
Ram Rajasekharan
Keyword(s):  
2014 ◽  
Vol 35 (1) ◽  
pp. 316-318 ◽  
Author(s):  
Wei Li ◽  
Ya Nan Sun ◽  
Xi Tao Yan ◽  
Seo Young Yang ◽  
Sung-Hoon Jo ◽  
...  

1969 ◽  
Vol 65 (3) ◽  
pp. 427-434 ◽  
Author(s):  
YOSHIKI TAKESUE ◽  
TSUTOMU KASHIWAGI

1963 ◽  
Vol 41 (1) ◽  
pp. 917-929 ◽  
Author(s):  
D. G. R. Blair ◽  
W. Yakimets ◽  
J. Tuba

Intestinal sucrase activity of the rat varies with the age, but not the sex, of the animal. Sucrase activity of rats 23 days of age was approximately two-thirds that of adults.Sucrase activity of adult rats was significantly decreased by several days of fasting. The decrease was rapid during the first 2 to 4 days of the fast, but became negligible thereafter.Diets containing large (70%) amounts of sucrose, galactose, melizitose, or α-methyl-D-glucoside produced highly significant increases in intestinal sucrase levels (compared with a carbohydrate-free, high-casein control diet) when fed ad libitum for 24 hours to adult male rats previously fasted for 3 days. Similar diets containing fructose, fructose plus glucose in equimolar amounts, or maltose significantly increased sucrase activity, but diets containing glucose, mannose, xylose, or lactose were not stimulatory. A 70% raffinose diet significantly decreased sucrase activity. Normal male rats which were fed the 70% sucrose diet for 4 weeks had sucrase activities similar to those of controls fed Purina fox checkers, but animals fed the carbohydrate-free, high-casein diet for 1 day or longer had sucrase activities significantly lower than those of controls. The significance of these observations in regard to enzyme "adaptation" is discussed.


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