sucrose diet
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2022 ◽  
Vol 11 (1) ◽  
pp. 49-57
Author(s):  
Qian Lin ◽  
Lina Yang ◽  
Lin Han ◽  
Ziyi Wang ◽  
Mingshuo Luo ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 22
Author(s):  
Tauqeerunnisa Syeda ◽  
Mónica Sánchez-Tapia ◽  
Itzel Orta ◽  
Omar Granados-Portillo ◽  
Lizbeth Pérez-Jimenez ◽  
...  

Obesity is associated with cognitive deficit and liver alterations; however, it remains unclear whether a combination of functional foods could reverse cognitive damage and to what extent it would be associated with changes in gut microbiota and liver. With this aim, male Wistar rats were fed a high-fat-5%sucrose diet (HFS) for 4 mo. And were then fed for 1 mo. with bioactive foods. At the end of this period, liver, serum, feces, intestine, and brain samples were taken. Body composition, energy expenditure, LPS, hormones, intraperitoneal glucose tolerance test, behavioral tests, and gut microbiota were evaluated. We showed that male rats fed high-fat-sucrose diet developed gut microbiota dysbiosis, increased in body fat, decreased antioxidant activity, decreased brain neuropeptide Y, increased the number of astrocytes and activated microglia, along with reduced spine density associated with deficits in working memory. Ingestion of a combination of nopal, soy protein, curcumin, and chia seed oil (bioactive foods) for three months was associated with an increase in a cluster of bacteria with anti-inflammatory capacity, a decrease in serum LPS levels and an increase in serum eicosapentaenoic acid (EPA) with neuroprotective properties. In the liver, ingestion of bioactive food significantly increased antioxidant enzymes, decreased lipogenesis, reduced inflammation mediated by the TLR4-TNFα pathway along with a decrease in body fat, glucose intolerance, and metabolic inflexibility. Finally, neuroinflammation in the brain was reduced and working memory improved. Our study demonstrates that consumption of bioactive foods was associated with reduced liver, brain, and gut microbiota alterations in obese rats.


2021 ◽  
pp. 2100730
Author(s):  
Jieping Yang ◽  
Patrizia Maria Germano ◽  
Suwan Oh ◽  
Sijia Wang ◽  
Jing Wang ◽  
...  

2021 ◽  
pp. 100156
Author(s):  
Florine Essouman Mbappe ◽  
Ferdinand Lanvin Edoun Ebouel ◽  
Fils Armand Ella ◽  
Bruno Dupon Ambamba Akamba ◽  
Jules Kamga Nanhah ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Djésia Arnone ◽  
Marie Vallier ◽  
Sébastien Hergalant ◽  
Caroline Chabot ◽  
Ndeye Coumba Ndiaye ◽  
...  

Nutrition appears to be an important environmental factor involved in the onset of inflammatory bowel diseases (IBD) through yet poorly understood biological mechanisms. Most studies focused on fat content in high caloric diets, while refined sugars represent up to 40% of caloric intake within industrialized countries and contribute to the growing epidemics of inflammatory diseases. Herein we aim to better understand the impact of a high-fat-high-sucrose diet on intestinal homeostasis in healthy conditions and the subsequent colitis risk. We investigated the early events and the potential reversibility of high caloric diet-induced damage in mice before experimental colitis. C57BL/6 mice were fed with a high-fat or high-fat high-sucrose or control diet before experimental colitis. In healthy mice, a high-fat high-sucrose diet induces a pre-IBD state characterized by gut microbiota dysbiosis with a total depletion of bacteria belonging to Barnesiella that is associated with subclinical endoscopic lesions. An overall down-regulation of the colonic transcriptome converged with broadly decreased immune cell populations in the mesenteric lymph nodes leading to the inability to respond to tissue injury. Such in-vivo effects on microbiome and transcriptome were partially restored when returning to normal chow. Long-term consumption of diet enriched in sucrose and fat predisposes mice to colitis. This enhanced risk is preceded by gut microbiota dysbiosis and transcriptional reprogramming of colonic genes related to IBD. Importantly, diet-induced transcriptome and microbiome disturbances are partially reversible after switching back to normal chow with persistent sequelae that may contribute to IBD predisposition in the general population.


2021 ◽  
pp. 113665
Author(s):  
Briannah Miles ◽  
William Yang ◽  
Gabi Dezsi ◽  
Elysia Sokolenko ◽  
Flávia M.M. Gomes ◽  
...  

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Jaqueline A. de Souza ◽  
Angélica B. Gonçalves Pinto ◽  
Emerson C. de Oliveira ◽  
Daniel B. Coelho ◽  
Nádia L. Totou ◽  
...  

Abstract Objective This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks. Results The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance. The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion. This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values. Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).


2021 ◽  
Author(s):  
David Julian Arias-Chávez ◽  
Patrick Mailloux-Salinas ◽  
Julio Altamirano ◽  
Fengyang Huang ◽  
Norma Leticia Gómez-Viquez ◽  
...  

Abstract The prevalence of the metabolic syndrome (MetS) and its cardiac comorbidities as cardiac hypertrophy (CH) have increased considerably due to the high consumption of carbohydrates, such as sucrose and/or fructose. We compared the effects of sucrose (S), fructose (F) and their combination (S + F) on the development of MetS in weaned male Wistar rats and established the relationship between the consumption of these sugars and the degree of cardiac CH development, oxidative stress (OS) and Calcium/calmodulin-dependent protein kinase type II subunit delta oxidation (ox-CaMKIIδ). 12 weeks after the beginning of treatments with S, F or S + F, arterial pressure (AP) was measured and 8 weeks later (to complete 20 weeks) the animals were sacrificed and blood samples, visceral adipose tissue and hearts were obtained. Biochemical parameters were determined in serum and cardiac tissue to evaluate the development of MetS and OS. To evaluate CH, atrial natriuretic peptide (ANP), CaMKIIδ and ox-CaMKIIδ were determined by western blot and histological studies were performed in cardiac tissue. Our data showed that chronic consumption of S + F exacerbates MetS-induced CH which is related with a higher OS and ox-CaMKIIδ.


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