scholarly journals Sulfated polysaccharide from the red algae Gelidiella acerosa: Anticoagulant, antiplatelet and antithrombotic effects

2020 ◽  
Vol 159 ◽  
pp. 415-421 ◽  
Author(s):  
Francisco Diêgo da Silva Chagas ◽  
Glauber Cruz Lima ◽  
Valesca Ingrid Nobre dos Santos ◽  
Luís Eduardo Castanheira Costa ◽  
Willer Malta de Sousa ◽  
...  
Keyword(s):  
Red Algae ◽  
Sulfated Polysaccharide ◽  
Gelidiella Acerosa ◽  
Antithrombotic Effects

scholarly journals An antithrombin-dependent sulfated polysaccharide isolated from the green alga Caulerpa cupressoides has in vivo anti- and prothrombotic effects

2011 ◽  
Vol 41 (4) ◽  
pp. 634-639 ◽  
Author(s):  
José Ariévilo Gurgel Rodrigues ◽  
Ismael Nilo Lino de Queiroz ◽  
Ana Luíza Gomes Quinderé ◽  
Bruno Cunha Vairo ◽  
Paulo Antônio de Souza Mourão ◽  
...  
Keyword(s):  
Body Weight ◽  
Green Algae ◽  
Red Algae ◽  
Sulfated Polysaccharide ◽  
Sulfated Polysaccharides ◽  
Antithrombotic Activity ◽  
Thrombin Inhibition ◽  
Antithrombotic Effects ◽  
Mechanism Of Interaction

Red algae sulfated polysaccharides (SPs) have been widely described as anticoagulant and antithrombotic agents; however no description of antithrombotic activity regarding green algae SPs has been reported. Caulerpa cupressoides (Chlorophyta) has three different SPs fractions (SP1, SP2 and SP3). We investigated the effects of SP2 on thrombin activity by antithrombin and in an experimental model of venous thrombosis in rats. The inhibition of thrombin assay was evaluated using antithrombin (AT) in the presence of SP2 and the antithrombotic activity was investigated in rats with thromboplastin as the thrombogenic stimulus. The anticoagulant effects of SP2 are suggested be due to the potentiation of thrombin inhibition by antithrombin (IC50 ~ 10.0µg mL-1) and this mechanism of interaction is different when compared to other studied Caulerpa polysaccharides. SP2 exhibited antithrombotic effects at doses of 1.0 and 2.0mg kg-1 body weight, but at higher doses (>2.0mg kg-1 body weight) this polysaccharide revert the antithrombotic property. No hemorrhagic effect (2.0mg kg-1) was observed. As occurs with red algae SPs, these results indicate that green algae SPs are also capable of exhibiting different in vivo properties.

Studies on the post-coital contraceptive mechanisms of crude extract of Sri Lankan marine red algae, Gelidiella acerosa

Contraception ◽  
1995 ◽  
Vol 52 (3) ◽  
pp. 203-207 ◽  
Author(s):  
G.A.S. Premakumara ◽  
W.D. Ratnasooriya ◽  
L.M.V. Tillekeratne
Keyword(s):  
Crude Extract ◽  
Red Algae ◽  
Sri Lankan ◽  
Gelidiella Acerosa

scholarly journals Sulfated-Polysaccharide Fraction from Red Algae Gracilaria caudata Protects Mice Gut Against Ethanol-Induced Damage

Marine Drugs ◽  
2011 ◽  
Vol 9 (11) ◽  
pp. 2188-2200 ◽  
Author(s):  
Renan Oliveira Silva ◽  
Geice Maria Pereira dos Santos ◽  
Lucas Antonio Duarte Nicolau ◽  
Larisse Tavares Lucetti ◽  
Ana Paula Macedo Santana ◽  
...  
Keyword(s):  
Red Algae ◽  
Sulfated Polysaccharide ◽  
Polysaccharide Fraction

scholarly journals Structural Characterization of Sulfated Polysaccharide Isolated From Red Algae (Gelidium crinale) and Antioxidant and Anti-Inflammatory Effects in Macrophage Cells

2021 ◽  
Vol 9 ◽  
Author(s):  
Yu Pei ◽  
Shengtao Yang ◽  
Zhenbang Xiao ◽  
Chunxia Zhou ◽  
Pengzhi Hong ◽  
...  
Keyword(s):  
Red Algae ◽  
Barium Chloride ◽  
Monosaccharide Composition ◽  
Sulfated Polysaccharide ◽  
Mitogen Activated Protein Kinase ◽  
Raw 264.7 Cells ◽  
Acid Extraction ◽  
Dependent Manner ◽  
Mitogen Activated Protein ◽  
Gelidium Crinale

Gelidium crinale, the red algae belonging to Geliaceae Gelidium, is a traditional edible and industrial alga in China. A sulfated polysaccharide (GNP) is successfully separated from Gelidium crinale by acid extraction and two-step column chromatography. Chemical analysis showed that the molecular weight of GNP was 25.8 kDa and the monosaccharide composition had the highest galactose content and confirmed the presence and content (16.5%) of sulfate by Fourier transform infrared spectroscopy (FT-IR) spectrometry as well as barium chloride-gelatin methods. In addition, the effect of GNP on lipopolysaccharide (LPS)-induced oxidative stress and inflammation in macrophages was also evaluated. The research results showed that GNP had fairly strong scavenging activities on 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and had Fe2+-chelating ability in a dose-dependent manner. At the same time, it significantly inhibits the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines in RAW 264.7 cells induced by LPS through blocking the mitogen-activated protein kinase (MAPK)/nuclear factor kappa beta (NF-κB) signaling pathway. These results indicate that GNP may be a latent component anti-inflammation in pharmaceutical and functional food industries.

Sulfated-polysaccharide fraction extracted from red algae G racilaria birdiae ameliorates trinitrobenzenesulfonic acid-induced colitis in rats

2014 ◽  
Vol 66 (8) ◽  
pp. 1161-1170 ◽  
Author(s):  
Tarcisio V. Brito ◽  
José P. R. P. Neto ◽  
Rafael S. Prudêncio ◽  
Jalles A. Batista ◽  
José S. C. Júnior ◽  
...  
Keyword(s):  
Red Algae ◽  
Sulfated Polysaccharide ◽  
Trinitrobenzenesulfonic Acid ◽  
Polysaccharide Fraction

scholarly journals Bioactivity and genetic screening of marine actinobacteria associated with red algae Gelidiella acerosa

2018 ◽  
Vol 22 (1) ◽  
pp. 13 ◽  
Author(s):  
Maria Ulfah ◽  
Noer Kasanah ◽  
Niken Satiti Nur Handayani
Keyword(s):  
Secondary Metabolites ◽  
Red Algae ◽  
Genetic Screening ◽  
Bacterial Resistance ◽  
Marine Actinobacteria ◽  
Gelidiella Acerosa ◽  
Peptide Synthetase ◽  
New Antibiotics ◽  
Mini Plate ◽  
Microtiter Assay

Bacterial resistance to existing antibiotics has driven a search for new antibiotics from marine actinobacteria. Bioactivity and genetic screening of actinobacteria associated with red algae Gelidiella acerosa were conducted to discover new antibacterial compounds against Vibrio alginolyticus. A total of 14 actinobacteria isolates were obtained from G. acerosa. The isolates were subjected to genetic screening for nrps (non-ribosomal peptide synthetase) and FADH2-dependent halogenase genes. The isolates’ ability to produce secondary metabolites was examined by fermentation in various media in a six-well mini plate. The bioactivity of the secondary metabolites was screened using a microtiter assay and the agar overlay method. The results showed that all 14 isolates had the nrps gene, whereas none had the halogenase gene. Meanwhile, eight of the actinobacteria isolates showed antibacterial activity against V. alginolyticus.

scholarly journals Biological Effects of a Sulfated-Polysaccharide Isolated from the Marine Red Algae Champia feldmannii

2008 ◽  
Vol 31 (4) ◽  
pp. 691-695 ◽  
Author(s):  
Ana Maria Sampaio Assreuy ◽  
Daniel Magalhães Gomes ◽  
Michelle Soares Josino da Silva ◽  
Valeska Martins Torres ◽  
Rômmulo Celly Lima Siqueira ◽  
...  
Keyword(s):  
Red Algae ◽  
Biological Effects ◽  
Sulfated Polysaccharide

scholarly journals Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa)

Marine Drugs ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 228 ◽  
Author(s):  
Koji Suzuki ◽  
Masahiro Terasawa
Keyword(s):  
Vascular Dysfunction ◽  
Biological Activities ◽  
Human Subjects ◽  
Biological Properties ◽  
Sulfated Polysaccharide ◽  
In Vivo Studies ◽  
Monostroma Nitidum ◽  
Antithrombotic Effects

Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary fibers, vitamins, and minerals. Rhamnan sulfate (RS), a sulfated polysaccharide, is main the component of the fiber extracted from M. nitidum. Recently, some biological properties of RS have been demonstrated by in vitro and in vivo studies that probably protect human subjects from viruses and ameliorate vascular dysfunction caused by metabolic disorders, especially lifestyle-related diseases. In this review, we focus on the antithrombotic effects of RS and introduce its antiviral and other biological activities.

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