Osteogenic growth peptide (OGP)-loaded amphiphilic peptide (NapFFY) supramolecular hydrogel promotes osteogenesis and bone tissue reconstruction

Composite biomaterials, like calciumphosphate/bioresorbable polymer, offer excellent potential for reconstruction and reparation of bone tissue defects induced by different sources. In this paper synthesis of calciumphosphate/poly-DL-lactide-co-glycolide (BCP/DLPLG) composite biomaterial formed as filler and blocks was studied. BCP/DLPLG composite biomaterial was produced in the form of spherical granules of BCP covered by a DLPLG layer, average diameter of 150-250 µm. By cold and hot pressing of granules at up to 10000 kg/cm2, blocks with fine distribution of phases and porosity up to 3% were obtained. Characterization was performed by wide-angle X-ray structural analysis (WAXS), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), infrared spectroscopy (IR), and mechanical properties by defining the compressive strength. In vitro citotoxicity research was carried out on cellular cultures of fibroblasts of human (MRC5) and mouse (L929). In vivo research was performed in two steps. Reparatory ability of BCP/DLPLG in mice was examined in the first step, and then bone tissue reconstruction possibilities on 10 patients in the next step. In vitro tests showed very good fibroblast adhesion and non-citotoxicity of the composite. A material is considered non-cytotoxic if the cell survival is above 50 %, and in our case it was 90%. In vivo research on mice indicated high level of reparatory ability of this composite with formation of new bone and vascular tissue six weeks after reparation. Application of this composite for healing infrabone defects of patients showed a high level of osseous regeneration.

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Fabrication of 3D porous SF/β-TCP hybrid scaffolds for bone tissue reconstruction

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.35711 ◽

2016 ◽

Vol 104 (7) ◽

pp. 1779-1787 ◽

Cited By ~ 14

Author(s):

Hyun Jung Park ◽

Kyung Dan Min ◽

Min Chae Lee ◽

Soo Hyeon Kim ◽

Ok Joo Lee ◽

...

Keyword(s):

Bone Tissue ◽

Tissue Reconstruction ◽

Hybrid Scaffolds

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Fracture behavior of Alumina-Tricalcium phosphate-Titania composites for bone tissue reconstruction

Engineering Fracture Mechanics ◽

10.1016/j.engfracmech.2021.107959 ◽

2021 ◽

pp. 107959

Author(s):

Rachida BARKALLAH ◽

Rym TAKTAK ◽

Zhu YAN ◽

Fahmi ZAÏRI ◽

Noamen GUERMAZI ◽

...

Keyword(s):

Bone Tissue ◽

Tricalcium Phosphate ◽

Fracture Behavior ◽

Tissue Reconstruction

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Fabrication of 3D porous silk scaffolds by particulate (salt/sucrose) leaching for bone tissue reconstruction

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2015.03.064 ◽

2015 ◽

Vol 78 ◽

pp. 215-223 ◽

Cited By ~ 48

Author(s):

Hyun Jung Park ◽

Ok Joo Lee ◽

Min Chae Lee ◽

Bo Mi Moon ◽

Hyung Woo Ju ◽

...

Keyword(s):

Bone Tissue ◽

Tissue Reconstruction ◽

Silk Scaffolds

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POSTTRAUMATIC DENSITY OF THE BONE TISSUE OF THE RAT’S MANDIBLE WITHOUT PATHOLOGY, ON THE BACKGROUND OF NALBUPHINE INTAKE AND AFTER LINCOMYCIN TREATMENT

World Science ◽

10.31435/rsglobal_ws/30112019/6772 ◽

2019 ◽

Vol 2 (11(51)) ◽

pp. 25-29

Author(s):

Rostyslav Sohuyko ◽

Zoryana Masna ◽

Khrystyna Pavliv

Keyword(s):

Bone Tissue ◽

Traumatic Injury ◽

Experimental Conditions ◽

X Ray ◽

Pathological Conditions ◽

Long Time ◽

Tissue Reconstruction ◽

Density Dynamics ◽

Ray Methods ◽

Qualitative Changes

Numerous dental manipulations are accompanied by bone injuries. Various types of drug correction are widely used for correction and optimization of bone tissue reconstruction after bone-traumatic injury. The evaluation of the course of reparative osteogenesis becomes possible with the x-ray methods which gives the possibility to evaluate and predict early quantitative and qualitative changes in various pathological conditions, as well as to trace their dynamics in clinical and experimental conditions. In our research we have find out the peculiarities of the density dynamics of the bone tissue of the mandible after causing bone-traumatic injury to intact animals and animals that have been taking nalbuphine for a long time, as well as after treatment with lincomycin.

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FEATURES OF BONE TISSUE RECONSTRUCTION IN PERIAND POSTMENOPAUSAL WOMEN WITH TYPE 1 DIABETES MELLITUS

Сибирский научный медицинский журнал ◽

10.15372/ssmj20180209 ◽

2018 ◽

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Postmenopausal Women ◽

Bone Tissue ◽

Tissue Reconstruction

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Wpływ propolisu na odnowę tkanki skórnej, kostnej, chrzęstnej i zębowej

Postępy Fitoterapii ◽

10.25121/pf.2018.19.3.203 ◽

2018 ◽

Vol 19 (3) ◽

Author(s):

Bogdan Kędzia ◽

Elżbieta Hołderna-Kędzia

Keyword(s):

Bone Tissue ◽

Research Literature ◽

Aqueous Extracts ◽

Cartilaginous Tissue ◽

Dental Tissues ◽

Significant Acceleration ◽

Tissue Reconstruction ◽

Ethanol Extracts ◽

Tooth Tissue ◽

Regeneration Of Skin

The research on the influence of ethanol and water extracts from propolis on the regeneration of tissues important for the organism, such as skin tissue, bone tissue, cartilaginous tissue, and tooth tissue have been conducted for over 50 years. The research literature of Polish scientists played a significant role in this respect. The research on the influence of propolis on the regeneration of skin, bone, cartilaginous and tooth tissue has been reviewed. Studies carried out on experimental animals indicate that both ethanol extracts (EEP) and aqueous extracts (WEP) from propolis are characterized by a distinct regenerating effect on the above mentioned types of tissues. There was noticed a significant acceleration of healing experimental wounds under the influence of EEP and WEP, accelerated bone tissue reconstruction as well as rapid reproduction of cartilaginous and dental tissues. In the context of the above data, it can be assumed that both EEP and WEP are characterized by a distinct, significant influence regenerating the skin, bone, cartilaginous and tooth tissues. These extracts can be successfully used in the treatment of disorders of these tissues in humans.

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