scholarly journals Association between myocardial fibrosis, as assessed with cardiac magnetic resonance T1 mapping, and persistent dyspnea after pulmonary embolism

2022 ◽  
Vol 38 ◽  
pp. 100935
Author(s):  
Jostein Gleditsch ◽  
Øyvind Jervan ◽  
Mazdak Tavoly ◽  
Oliver Geier ◽  
René Holst ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
T1 Mapping

scholarly journals Proteoglycan remodeling is accelerated in women with angina pectoris and diffuse myocardial fibrosis: the iPOWER Study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N.D Mygind ◽  
S Holm Nielsen ◽  
M Mide Michelsen ◽  
A Pena ◽  
D Bechsgaard Frestad ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Angina Pectoris ◽  
Myocardial Fibrosis ◽  
T1 Mapping ◽  
Obstructive Coronary Artery Disease ◽  
Extracellular Volume ◽  
Diffuse Myocardial Fibrosis ◽  
Public Institution ◽  
Funding Source

Abstract Background Women with angina and no obstructive coronary artery disease (CAD) have an unfavourable prognosis, possibly due to coronary microvascular disease and diffuse myocardial fibrosis (DMF). In DMF myocardial extracellular matrix (ECM) proteins are actively remodeled by matrix metalloproteinase (MMP). Purpose We investigated MMP-mediated degradation of the protegoglycans biglycan and versican in women with angina pectoris and possible DMF assessed by cardiac magnetic resonance T1 mapping. Methods Seventy-one women with angina pectoris and no obstructive CAD were included. Asymptomatic age-matched women served as controls (n=32). Versican and biglycan were measured in serum by specific competitive enzyme-linked immunosorbent assays. T1 mapping was performed by cardiac magnetic resonance with gadolinium measuring T1 and extracellular volume (ECV). Results Both biglycan and versican levels were higher in symptomatic women compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p<0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p<0.001), respectively (Figure 1) and were moderately correlated to global ECV (r2=0.38, p<0.001 and r2=0.26, p=0.015 respectively). Conclusion Turnover of biglycan and versican was increased in symptomatic compared to asymptomatic women and associated to ECV, supporting a link between angina with no obstructive CAD and fibrotic cardiac remodeling. The examined biomarkers may prove to be suitable for monitoring active ECM remodeling. Figure 1. Levels of BGM and VCANM Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): This work was supported by The Danish Heart Foundation, the Danish Research Fund (Den Danske Forskningsfond) and by University of Copenhagen.

scholarly journals Progression of diffuse myocardial fibrosis assessed by cardiac magnetic resonance T1 mapping

2014 ◽  
Vol 30 (7) ◽  
pp. 1339-1346 ◽  
Author(s):  
Colin J. Yi ◽  
Eunice Yang ◽  
Shenghan Lai ◽  
Neville Gai ◽  
Chia Liu ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Myocardial Fibrosis ◽  
T1 Mapping ◽  
Diffuse Myocardial Fibrosis

scholarly journals TO034NON-CONTRAST CARDIAC MAGNETIC RESONANCE T1 MAPPING AS A MARKER OF MYOCARDIAL FIBROSIS IN END STAGE RENAL DISEASE

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i75-i75
Author(s):  
Elaine Rutherford ◽  
Mohammed A Talle ◽  
Samuli Rauhalammi ◽  
Kenneth Mangion ◽  
Allan D Struthers ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Renal Disease ◽  
Myocardial Fibrosis ◽  
End Stage Renal Disease ◽  
T1 Mapping ◽  
Stage Renal Disease ◽  
End Stage
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