[P35]: Role of dbpA in neural crest and Schwann cell development

2006 ◽  
Vol 24 (8) ◽  
pp. 510-510
Author(s):  
F. Castagner ◽  
S. Atanasoski ◽  
M. Balda ◽  
K. Matter ◽  
U. Suter
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Cell Development ◽  
Schwann Cell Development

scholarly journals The role of chromatin remodeling complexes in Schwann cell development

Glia ◽  
2019 ◽  
Vol 68 (8) ◽  
pp. 1596-1603 ◽  
Author(s):  
Franziska Fröb ◽  
Michael Wegner
Keyword(s):  
Schwann Cell ◽  
Chromatin Remodeling ◽  
Cell Development ◽  
Schwann Cell Development ◽  
Chromatin Remodeling Complexes

Schwann cell development: From neural crest to myelin sheath

2020 ◽  
Author(s):  
Anoohya N. Muppirala ◽  
Lauren E. Limbach ◽  
Elisabeth F. Bradford ◽  
Sarah C. Petersen
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Myelin Sheath ◽  
Cell Development ◽  
Schwann Cell Development

scholarly journals The role of NF1 in Schwann Cell development and tumor formation and the influence of steroid hormones and metabolites

2007 ◽  
Vol 306 (1) ◽  
pp. 430
Author(s):  
Therese M. Roth ◽  
Poornapriya Ramamurthy ◽  
Fumi Ebisu ◽  
Kate F. Barald
Keyword(s):  
Schwann Cell ◽  
Steroid Hormones ◽  
Cell Development ◽  
Tumor Formation ◽  
Schwann Cell Development

scholarly journals A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool

2000 ◽  
Vol 148 (5) ◽  
pp. 1035-1046 ◽  
Author(s):  
Alistair N. Garratt ◽  
Octavian Voiculescu ◽  
Piotr Topilko ◽  
Patrick Charnay ◽  
Carmen Birchmeier
Keyword(s):  
Schwann Cell ◽  
Tyrosine Kinases ◽  
Cell Development ◽  
Cell Precursor ◽  
Neuregulin 1 ◽  
Precursor Pool ◽  
Schwann Cell Development ◽  
Spinal Roots ◽  
Survival And Growth

Neuregulin-1 provides an important axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases. Null mutations of the neuregulin-1, erbB2, or erbB3 mouse genes cause severe deficits in early Schwann cell development. Here, we employ Cre-loxP technology to introduce erbB2 mutations late in Schwann cell development, using a Krox20-cre allele. Cre-mediated erbB2 ablation occurs perinatally in peripheral nerves, but already at E11 within spinal roots. The mutant mice exhibit a widespread peripheral neuropathy characterized by abnormally thin myelin sheaths, containing fewer myelin wraps. In addition, in spinal roots the Schwann cell precursor pool is not correctly established. Thus, the Neuregulin signaling system functions during multiple stages of Schwann cell development and is essential for correct myelination. The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon.

scholarly journals Retracing Schwann Cell Developmental Transitions in Embryonic Dissociated DRG/Schwann Cell Cocultures in Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Venkat Krishnan Sundaram ◽  
Tatiana El Jalkh ◽  
Rasha Barakat ◽  
Camille Julie Isabelle Fernandez ◽  
Charbel Massaad ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Expression Profiles ◽  
Cell Development ◽  
Immature Stage ◽  
Developmental Transitions ◽  
Molecular Events ◽  
Schwann Cell Development

Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination. These cultures largely recapitulate the order of cellular and molecular events that occur in Schwann cells of embryonic nerves. However, the timing of Schwann cell developmental transitions, notably the transition from Schwann Cell Precursors (SCP) to immature Schwann cells (iSC) and then to myelinating Schwann cells, has not been estimated so far in this culture system. In this study, we determined the expression profiles of Schwann cell developmental genes during the first week of culture and then compared our data to the expression profiles of these genes in developing spinal nerves. This helped in identifying that SCP transition into iSC between the 5th and 7th day in vitro. Furthermore, we also investigated the transition of immature cells into pro-myelinating and myelinating Schwann cells upon the induction of myelination in vitro. Our results suggest that Schwann cell differentiation beyond the immature stage can be observed as early as 4 days post the induction of myelination in cocultures. Finally, we compared the myelinating potential of coculture-derived Schwann cell monocultures to cultures established from neonatal sciatic nerves and found that both these culture systems exhibit similar myelinating phenotypes. In effect, our results allow for a better understanding and interpretation of coculture experiments especially in studies that aim to elucidate the role of a novel actor in Schwann cell development and myelination.

scholarly journals Retracing Schwann cell developmental transitions in embryonic dissociated DRG cultures

2020 ◽  
Author(s):  
Venkat Krishnan Sundaram ◽  
Rasha Barakat ◽  
Charbel Massaad ◽  
Julien Grenier
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Reference Genes ◽  
Expression Profiles ◽  
Cell Development ◽  
Developmental Genes ◽  
Developmental Transitions ◽  
Schwann Cell Development ◽  
Schwann Cell Precursors

AbstractEmbryonic Dissociated Dorsal Root Ganglia cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination. These cultures largely recapitulate the order of cellular and molecular events that occur in Schwann cells of embryonic nerves. However, the timing of Schwann cell developmental transitions, notably the transition from Schwann Cell Precursors to immature Schwann cells, has not been estimated so far in this culture system. In this study, we use RTqPCR to determine the expression profiles of Schwann cell developmental genes during the first week of culture. We first identified stable reference genes that show minimal variation across different experimental time points. Consequently, we normalized the mRNA profiles of Schwann cell developmental genes using the best internal reference genes. We then compared our data to the expression profiles of these genes in developing spinal nerves elaborated in numerous high-throughput and lineage tracing studies. This comparison helped in identifying that Schwann Cell Precursors transition into immature Schwann Cells between the 5th and 7th day in vitro. In effect, our data allows for a better understanding and interpretation of DRG culture experiments especially in studies that aim to elucidate the role of a novel gene in Schwann Cell development and myelination.

Analysis of connexin expression during mouse Schwann cell development identifies Connexin29 as a novel marker for the transition of neural crest to precursor cells

Glia ◽  
2006 ◽  
Vol 55 (1) ◽  
pp. 93-103 ◽  
Author(s):  
Jing Li ◽  
Hans-Werner Habbes ◽  
Jürgen Eiberger ◽  
Klaus Willecke ◽  
Rolf Dermietzel ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Neural Crest ◽  
Cell Development ◽  
Precursor Cells ◽  
Connexin Expression ◽  
Schwann Cell Development

scholarly journals Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer

Neurosurgery ◽  
2020 ◽  
Author(s):  
Harish N Vasudevan ◽  
Calixto-Hope G Lucas ◽  
Javier E Villanueva-Meyer ◽  
Philip V Theodosopoulos ◽  
David R Raleigh
Keyword(s):  
Schwann Cell ◽  
Cell Fate ◽  
Cell Development ◽  
Nerve Sheath Tumor ◽  
Cell Lineages ◽  
Nerve Sheath ◽  
Signaling Mechanisms ◽  
Schwann Cell Development ◽  
Novel Therapeutic Strategies ◽  
Genetic Events

Abstract In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.

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