Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation

2018 ◽  
Vol 68 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Maryam Azizi ◽  
Parichehr Pasbakhsh ◽  
Seyed Alireza Nadji ◽  
Mihan Pourabdollah ◽  
Tahmineh Mokhtari ◽  
...  
Keyword(s):  
Mouse Model ◽  
Therapeutic Effect ◽  
Antioxidative Enzymes ◽  
Histopathological Changes ◽  
Cortical Malformation ◽  
Exogenous Melatonin

Therapeutic Effect of Kakkonto in a Mouse Model of Food Allergy with Gastrointestinal Symptoms

2009 ◽  
Vol 148 (3) ◽  
pp. 175-185 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Kanae Fujiwara ◽  
Minako Yoshida ◽  
Natsuko Kageyama-Yahara ◽  
Hirofumi Kuramoto ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Gastrointestinal Symptoms

scholarly journals Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0134142 ◽  
Author(s):  
Wenxiao Jiang ◽  
Wenjie Wei ◽  
Marta A. Gaertig ◽  
Shihua Li ◽  
Xiao-Jiang Li
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transgenic Mouse ◽  
Therapeutic Effect ◽  
Transgenic Mouse Model

Effect of Huangqin Decoction on Improving the Mouse Model of Ulcerative Colitis by Inhibiting NF-κB p65 Signal Pathway

2021 ◽  
Vol 11 (7) ◽  
pp. 1394-1399
Author(s):  
Yinyu Wang ◽  
Chenxi Zheng ◽  
Ningning Cheng ◽  
Cong Sun
Keyword(s):  
Ulcerative Colitis ◽  
Mouse Model ◽  
Signaling Pathway ◽  
Nuclear Factor ◽  
Histopathological Changes ◽  
Colon Tissue ◽  
Chinese Medicinal Herb ◽  
Western Blots ◽  
Natural Medicine ◽  
New Strategy

Natural medicine, such as traditional Chinese medicine, plays a role in treating ulcerative colitis (UC) because of its action on multiple targets. Here we have improved the effectiveness of a traditional Chinese medicinal herb, Huangqin decoction (HQD), on UC via the nuclear factor-κB (NF-κB) p65 signaling pathway in a mouse model. NF-κB is a crucial regulator of inflammation, cancer, and autoimmunity. It may be related to the initiation and development of UC. Histopathological changes in colon show that Huangqin Decoction can improve colon tissue environment In addition, the Western blots of the inflammatory cytokines related to the NF-κB p65 pathway suggest that HQD inhibits the development of UC by regulating the NF-κB p65 signaling pathway. These findings provide a basis for the clinical application of HQD and suggest a new strategy for treating UC in the future.

The therapeutic effect of dendritic cells expressing indoleamine 2,3-dioxygenase (IDO) on an IgA nephropathy mouse model

2020 ◽  
Vol 52 (2) ◽  
pp. 399-407 ◽  
Author(s):  
Kanghan Liu ◽  
Yiya Yang ◽  
Yinyin Chen ◽  
Shiyao Li ◽  
Yuting Gong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Mouse Model ◽  
Iga Nephropathy ◽  
Therapeutic Effect ◽  
Indoleamine 2,3 Dioxygenase

scholarly journals 1025. Therapeutic Effect of a Self-Cleaving Hammerhead Ribozyme in a Mouse Model of Osteogenesis Imperfecta

2006 ◽  
Vol 13 ◽  
pp. S394
Author(s):  
Belinda E. Peace ◽  
Christopher J. Frede ◽  
Jane B. Florer ◽  
Michael W. Kilpatrick ◽  
Petros Tsipouras ◽  
...  
Keyword(s):  
Mouse Model ◽  
Osteogenesis Imperfecta ◽  
Therapeutic Effect ◽  
Hammerhead Ribozyme

scholarly journals Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

Prion ◽  
2012 ◽  
Vol 6 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Giorgio Poli ◽  
Erica Corda ◽  
Barbara Lucchini ◽  
Maria Puricelli ◽  
Piera Anna Martino ◽  
...  
Keyword(s):  
Mouse Model ◽  
Therapeutic Effect
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