Domain specificity of personal epistemology: Resolved questions, persistent issues, new models

2006 ◽  
Vol 45 (1-2) ◽  
pp. 85-95 ◽  
Author(s):  
Barbara K. Hofer
1975 ◽  
Vol 20 (5) ◽  
pp. 431-432
Author(s):  
ANTHONY G. GREENWALD

1996 ◽  
Vol 41 (8) ◽  
pp. 828-829
Author(s):  
Amanda L. Woodward
Keyword(s):  

1969 ◽  
Vol 14 (8) ◽  
pp. 421-423 ◽  
Author(s):  
W. ROBERT DIXON

2011 ◽  
Author(s):  
Susanne M. Jaeggi ◽  
Martin Buschkuehl ◽  
John Jonides

2006 ◽  
Author(s):  
David A. Washburn ◽  
Michael J. Beran ◽  
Theodore A. Evans ◽  
Eric J. Vanman
Keyword(s):  

2011 ◽  
Author(s):  
Hiroyuki Yoshizawa ◽  
Makoto Nakajima ◽  
Takuya Yoshida ◽  
Chika Harada ◽  
Koji Tsuchiya

1996 ◽  
Vol 76 (05) ◽  
pp. 749-754 ◽  
Author(s):  
Suzuki Suzuki ◽  
Morio Arai ◽  
Kagehiro Amano ◽  
Kazuhiko Kagawa ◽  
Katsuyuki Fukutake

SummaryIn order to clarify the potential role of von Willebrand factor (vWf) in attenuating the inactivation of factor VIII (fVIII) by those antibodies with C2 domain specificity, we investigated a panel of 14 human antibodies to fVIII. Immunoblotting analysis localized light chain (C2 domain) epitopes for four cases, heavy chain (A2 domain) epitopes in five cases, while the remaining five cases were both light and heavy chains. The inhibitor titer was considerably higher for Kogenate, a recombinant fVIII concentrate, than for Haemate P, a fVIII/vWf complex concentrate, in all inhibitor plasmas that had C2 domain specificity. In five inhibitor plasmas with A2 domain specificity and in five with both A2 and C2 domain specificities, Kogenate gave titers similar to or lower than those with Haemate P. The inhibitory effect of IgG of each inhibitor plasma was then compared with recombinant fVIII and its complex with vWf. When compared to the other 10 inhibitor IgGs, IgG concentration, which inhibited 50% of fVIII activity (IC50), was remarkably higher for the fVIII/vWf complex than for fVIII in all the inhibitor IgGs that had C2 domain reactivity. Competition of inhibitor IgG and vWf for fVIII binding was observed in an ELISA system. In 10 inhibitors that had C2 domain reactivity, the dose dependent inhibition of fVIII-vWf complex formation was observed, while, in the group of inhibitors with A2 domain specificity, there was no inhibition of the complex formation except one case. We conclude that a subset of fVIII inhibitors, those that bind to C2 domain determinants, are less inhibitory to fVIII when it is complexed with vWf that binds to overlapping region in the C2 domain.


2016 ◽  
pp. 5-33 ◽  
Author(s):  
V. Mau

The paper deals with 2015 trends and challenges for social and economic policy in the nearest future. The analysis of global crisis includes: uneven developments in the leading advanced and emerging economies; new models of economic growth which look differently in different countries; prospects of globalization and challenges of ‘regional globalization’; currency configurations of the future; energy prices dynamics and its influence on political and economic prospects of particular states. Current challenges are discussed in the context of previous 30 years. Among the main topics on Russia, there are approaches to a new growth model, structural transformation (including import substitution issues), economic dynamics, budget and monetary outlines, social issues. The priorities of economic policy are also considered.


2020 ◽  
pp. 84-107
Author(s):  
Vera Borges ◽  
Luísa Veloso

In the wake of the 2008 global financial and economic crisis, new forms of work organization emerged in Europe. Following this trend, Portugal has undergone a reconfiguration of its artistic organizations. In the performing arts, some organiza-tions seem to have crystalized and others are reinventing their artistic mission. They follow a plurality of organizational patterns and resilient profiles framed by cyclical, structural and occupational changes. Artistic organizations have had to adopt new models of work and seek new opportunities to try out alternatives in order to deal, namely, with the constraints of the labour market. The article anal-yses some of the restructuring processes taking place in three Portuguese artistic organizations, focusing on their contexts, individual trajectories and collective missions for adapting to contemporary challenges of work in the arts. We conclude that organizations are a key domain for understanding the changes taking place.


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