Experiments are preformed to investigate the effect of channel orientation in a rotating wedge-shaped cooling channel with lateral flow extraction. The test section bears the following characteristics. Staggered ribs are arranged in the inner wide region of the channel, while the pin-fins are located in the outer narrow region. The regionally averaged heat transfer coefficients are obtained to study the characteristics of heat transfer variations in this channel under rotating and non-rotating conditions. The experiments are conducted under four inlet Reynolds numbers (6100, 15000, 25100, 33000), five rotational speeds (0, 300, 500, 800, 1000rpm) and three channel orientations (90°, 135°, 180° angle from the channel symmetry plan to the rotating plan). The inlet rotation number ranges from zero to 0.62. Finally, the experimental data demonstrates that the streamwise heat transfer variations under rotating condition are strongly affected by channel orientation in this configuration. Furthermore, compared with the data under two channel orientation 90° and 180° (the direction of rotation is perpendicular and parallel to the channel symmetry plan), the heat transfer characteristics under 135° configuration, which is regarded as the typical trailing edge orientation, approaches to the 180° one in this rotating channel. An evident critical rotation number, after which the nature of heat transfer changes abruptly, exists under 180° and 135° configuration but not under 90° one.