scholarly journals First insight into latent tuberculosis infection among household contacts of tuberculosis patients in Duhok, Iraqi Kurdistan: using tuberculin skin test and QuantiFERON-TB Gold Plus test

2020 ◽  
Vol 96 ◽  
pp. 97-104
Author(s):  
Fatima Nawaf Abdulkareem ◽  
Muayad Aghali Merza ◽  
Ahmed Mohammed Salih
Keyword(s):  
Tuberculin Skin Test ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Tuberculosis Patients ◽  
Household Contacts ◽  
Iraqi Kurdistan ◽  
Insight Into

scholarly journals Comparison of Tuberculin Skin Test and a Specific T-cell-based Test, T-Spot™. TB, for the Diagnosis of Latent Tuberculosis Infection

2007 ◽  
Vol 35 (5) ◽  
pp. 696-703 ◽  
Author(s):  
T Ozekinci ◽  
E Ozbek ◽  
Y Celik
Keyword(s):  
T Cells ◽  
Tuberculin Skin Test ◽  
Skin Test ◽  
Latent Tuberculosis Infection ◽  
Ex Vivo ◽  
Latent Tuberculosis ◽  
Risk Groups ◽  
Tuberculosis Infection ◽  
Tuberculosis Patients ◽  
Lung Tuberculosis

There is substantial evidence that the detection of T cells specific for the proteins ESAT-6 and CFP-10 using the ex vivo enzyme-linked immunospot technique is a marked improvement on the existing tuberculin skin test (TST). This new technique, which detects γ-interferon-producing T cells, is now available as the commercial assay, T-Spot™.TB. We compared the T-Spot™.TB test with the TST for the diagnosis of latent tuberculosis infection (LTBI) in different groups of subjects. Significant accordance (85.7%) between the tests was found in subjects with active lung tuberculosis and in tuberculosis clinic and laboratory personnel (63.6%) but accordance was lowest and not significant amongst house contacts of tuberculosis patients (53.6%). We conclude that, in countries where vaccination is routinely performed, the T-Spot™.TB test is a useful diagnostic test for LTBI in high-risk groups when carried out either together with the TST and/or to confirm the TST result.

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