scholarly journals Phenotypic and genotypic analysis of benzimidazole resistance in reciprocal genetic crosses of Haemonchus contortus

2021 ◽  
Author(s):  
A.A. Morrison ◽  
U. Chaudhry ◽  
L. Andrews ◽  
L. Melville ◽  
S.R. Doyle ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Genetic Crosses ◽  
Benzimidazole Resistance ◽  
Genotypic Analysis

Identification and quantification of benzimidazole resistance polymorphisms in Haemonchus contortus isolated in Northeastern Brazil

2014 ◽  
Vol 199 (3-4) ◽  
pp. 160-164 ◽  
Author(s):  
Jessica Maria Leite dos Santos ◽  
Jomar Patrício Monteiro ◽  
Wesley Lyeverton Correia Ribeiro ◽  
Iara Tersia Freitas Macedo ◽  
Ana Lourdes Fernandes Camurça-Vasconcelos ◽  
...  
Keyword(s):  
Haemonchus Contortus ◽  
Northeastern Brazil ◽  
Benzimidazole Resistance ◽  
Identification And Quantification

scholarly journals Frequency of benzimidazole resistance inHaemonchus contortus populations isolated from buffalo, goat and sheep herds

2013 ◽  
Vol 22 (4) ◽  
pp. 548-553 ◽  
Author(s):  
Ronaldo Luiz Nunes ◽  
Livia Loiola dos Santos ◽  
Eduardo Bastianetto ◽  
Denise Aparecida Andrade de Oliveira ◽  
Bruno Santos Alves Figueiredo Brasil
Keyword(s):  
Haemonchus Contortus ◽  
Significant Variation ◽  
Genetic Basis ◽  
Anthelmintic Resistance ◽  
Allelic Frequency ◽  
Molecular Diagnostic ◽  
Economic Losses ◽  
Diagnostic Tools ◽  
Ruminant Species ◽  
Benzimidazole Resistance

Anthelmintic resistance is an increasing problem that threatens livestock production worldwide. Understanding of the genetic basis of benzimidazole resistance recently allowed the development of promising molecular diagnostic tools. In this study, isolates of Haemonchus contortus obtained from goats, sheep and buffaloes raised in Brazil were screened for presence of the polymorphism Phe200Tyr in the β-tubulin 1 gene, which confers resistance to benzimidazole. The allelic frequency of the mutation conferring resistance ranged from 7% to 43%, and indicated that resistance to benzimidazole could be found in nematodes isolated from all the ruminant species surveyed. Although significant variation in the frequency of the F200Y mutation was observed between different herds or host species, no significant variation could be found in populations isolated from animals within the same herd. These findings suggest that screening of samples from a few animals has the potential to provide information about the benzimidazole resistance status of the entire herd, which would enable a considerable reduction in the costs of diagnosis for the producer. Molecular diagnosis has practical advantages, since it can guide the choice of anthelmintic drug that will be used, before its application in the herd, thus reducing the economic losses driven by anthelmintic resistance.

Molecular detection of benzimidazole resistance levels associated with F167Y and F200Y polymorphisms in Haemonchus contortus of goats from Mozambique

2018 ◽  
Vol 118 (1) ◽  
pp. 245-253 ◽  
Author(s):  
Alsácia Atanásio-Nhacumbe ◽  
Sabrina Mota Lambert ◽  
Bárbara Maria Paraná da Silva Souza ◽  
Maria Consuêlo Carybé Ayres
Keyword(s):  
Haemonchus Contortus ◽  
Molecular Detection ◽  
Benzimidazole Resistance
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