Diclofenac sodium delivery to the eye: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct

2008 ◽  
Vol 355 (1-2) ◽  
pp. 307-313 ◽  
Author(s):  
Anthony A. Attama ◽  
Stephan Reichl ◽  
Christel C. Müller-Goymann
Keyword(s):  
Diclofenac Sodium ◽  
Human Cornea ◽  
Solid Lipid Nanoparticle ◽  
In Vitro Evaluation ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Nanoparticle Formulation

Design and In Vitro Evaluation of Solid-Lipid Nanoparticle Drug Delivery for Aceclofenac

2012 ◽  
Vol 33 (1) ◽  
pp. 96-102 ◽  
Author(s):  
Narra Kishore ◽  
U. M. Dhanalekshmi ◽  
M. D. Raja ◽  
Saranya Bhavani ◽  
P. Neelakanta Reddy
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticle ◽  
In Vitro Evaluation ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Nanoparticle Drug Delivery

scholarly journals Solid lipid nanoparticle induced apoptosis of macrophages via a mitochondrial-dependent pathway in vitro and in vivo

2019 ◽  
Vol Volume 14 ◽  
pp. 3283-3295 ◽  
Author(s):  
Wan-Li Liang ◽  
Lan Xiao ◽  
Hong-Wei Gu ◽  
Xiao-Jun Li ◽  
Yu-Sang Li ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Induced Apoptosis ◽  
Dependent Pathway

Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne

2007 ◽  
Vol 24 (5) ◽  
pp. 395-407 ◽  
Author(s):  
Gisele A. Castro ◽  
Rodrigo L. Oréfice ◽  
José M. C. Vilela ◽  
Margareth S. Andrade ◽  
Lucas A. M. Ferreira
Keyword(s):  
Retinoic Acid ◽  
Topical Treatment ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Nanoparticle Formulation

scholarly journals Formulation of Solid Lipid Nanoparticles of Cilnidipine for the Treatment of Hypertension

2019 ◽  
Vol 9 (3) ◽  
pp. 212-221 ◽  
Author(s):  
Aparna Bhalerao ◽  
Pankaj Prakash Chaudhari
Keyword(s):  
Particle Size ◽  
Solid Lipid Nanoparticles ◽  
Encapsulation Efficiency ◽  
Drug Loading ◽  
Lipid Nanoparticles ◽  
Water Soluble ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle

Cilinidipine is a fourth generation N and L-type calcium channel antagonists used alone or in combination with another drug to treat hypertension. Cilnidipine is poorly water -soluble, BCS class II drug with 6 to 30 percent oral bioavailability due to first pass metabolism. So to protect the drug from degradation and improve its dissolution, solid lipid nanoparticles were prepared. Glyceryl monostearate was selected as lipid while span 20: tween 20 were selected as surfactant blends. The formulations were evaluated for various parameters, as percent transmittance, drug content, percent encapsulation efficiency; percent drug loading, In vitro drug release and particle size. Optimized formulation was lyophilized using lactose as a cryo-protectant. The lyophilized formulation was evaluated for micromeritic properties, particle size and in vitro dissolution. It was further evaluated for DSC, XRD, and SEM. Percent encapsulation efficiency and percent drug loading of optimized formulation (F3) were 78.66percent and 9.44percent respectively. The particle size of F3 formulation without drug was 204 nm and with the drug was 214 nm. The particle size of the reconstituted SLN was 219 nm. In DSC study, no obvious peaks for cilnidipine were found in the SLN of cilnidipine indicated that the cilnidipine must be present in a molecularly dissolved state in SLN. In X-ray diffractometry absence of peaks representing crystals of cilnidipine in SLN indicated that the drug was in an amorphous or disordered crystalline phase in the lipid matrix. Thus, solid lipid nanoparticle formulation is a promising way to enhance the dissolution rate of cilnidipine. Keywords: Cilnidipine, Solid Lipid Nanoparticle, Hypertension

scholarly journals Assessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits

2021 ◽  
Vol Volume 16 ◽  
pp. 7847-7857
Author(s):  
Zhen Liang ◽  
Zhen Zhang ◽  
Jingjing Yang ◽  
Ping Lu ◽  
Tianyang Zhou ◽  
...  
Keyword(s):  
Ocular Pharmacokinetics ◽  
Solid Lipid Nanoparticle ◽  
Solid Lipid ◽  
Lipid Nanoparticle ◽  
Antifungal Effects
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