Development and characterization of fast dissolving tablets of oxaprozin based on hybrid systems of the drug with cyclodextrins and nanoclays

AbstractNew hybrid molecules containing fluoroquinolone-barbiturate moieties were synthesized via simple routes, followed by characterization using various spectroscopic approaches. The THF solvent molecule was incorporated into compounds 2 and 3 through its oxygen atom based on its nucleophilicity. Facile displacement of the chloride ion in 4-oxoquinoline-3-carbonyl chloride by the nucleophilic methylene carbon of 1,3-dialkylbarbiturate/thiobarbiturate afforded the respective hybrids 5 and 6.

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Observability and Geometric Approach of 2D Hybrid Systems

International Journal of Computers ◽

10.46300/9108.2021.15.18 ◽

2021 ◽

Vol 15 ◽

pp. 115-122

Author(s):

Tiberiu Vasilache ◽

Valeriu Prepelita

Keyword(s):

Systems Theory ◽

Hybrid Systems ◽

Geometric Approach ◽

Geometric Characterization ◽

2D Systems ◽

Special Regard ◽

Observability Gramian

A connection is emphasized between two branches of the Systems Theory, namely the Geometric Approach and 2D Systems, with a special regard to the concept of observability. An algorithm is provided which determines the maximal subspace which is invariant with respect to two commutative matrices and which is included in a given subspace. Observability criteria are obtained for a class of 2D systems by using a suitable 2D observability Gramian and some such criteria are derived for LTI 2D systems, as well as the geometric characterization of the subspace of unobservable states. The presented algorithm is applied to determine this subspace.

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A characterization of integral input-to-state stability for hybrid systems

Mathematics of Control Signals and Systems ◽

10.1007/s00498-017-0199-4 ◽

2017 ◽

Vol 29 (3) ◽

Cited By ~ 5

Author(s):

Navid Noroozi ◽

Alireza Khayatian ◽

Roman Geiselhart

Keyword(s):

Hybrid Systems

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Preparation and Characterization of Novel Electrospinnable PBT/POSS Hybrid Systems Starting from c-PBT

Journal of Nanomaterials ◽

10.1155/2015/101674 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8

Author(s):

Lorenza Gardella ◽

Alberto Fina ◽

Orietta Monticelli

Keyword(s):

Hybrid Systems ◽

Hybrid System ◽

Ring Opening ◽

Ring Opening Polymerization ◽

Polymerization Reaction ◽

Polyhedral Oligomeric Silsesquioxanes ◽

Polymer Backbone ◽

Reactive Groups

Novel hybrid systems based on poly(butyleneterephthalate) (PBT) and polyhedral oligomeric silsesquioxanes (POSS) have been prepared by applying the ring-opening polymerization of cyclic poly(butyleneterephthalate) oligomers. Two types of POSS have been used: one characterized by hydroxyl functionalities (named POSS-OH) and another without specific reactive groups (named oib-POSS). It was demonstrated that POSS-OH acts as an initiator for the polymerization reaction, leading to the direct insertion of the silsesquioxane into the polymer backbone. Among the possible applications of the PBT/POSS hybrid system, the possibility to obtain nanofibers has been assessed in this work.

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