Design of a pH-responsive oral gel formulation based on the matrix systems of gelatin/hydroxypropyl methylcellulose phthalate for controlled drug release

2021 ◽  
Vol 592 ◽  
pp. 120047
Author(s):  
Satoshi Nogami ◽  
Hiromasa Uchiyama ◽  
Kazunori Kadota ◽  
Yuichi Tozuka
RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44516-44523 ◽  
Author(s):  
Gholam Reza Mahdavinia ◽  
Sanaz Ettehadi ◽  
Mojtaba Amini ◽  
Mohammad Sabzi

pH-responsive magnetic nanocomposite hydrogels based on hydroxypropyl methylcellulose-g-poly(acrylamide)/LAPONITE® RD (HPMC-g-PAALap) were developed.


Author(s):  
AKPABIO E. I. ◽  
EFFIONG D. E. ◽  
UWAH T. O. ◽  
SUNDAY N. I.

Objective: This study was undertaken to formulate a floating drug delivery system of theophylline hydrochloride using different concentrations of a chosen polymer and then investigate how polymer concentration affects buoyancy and drug release properties of the tablets. Methods: Hydroxypropyl methylcellulose (HPMC) at different concentration levels of 15% (F1), 20% (F2) and 30% (F3) was used to form the three formulation batches of floating tablets. Wet granulation method was used for the granule preparation while Sodium bicarbonate and citric acid were used as the gas generating agent. The physical properties of the granules and the floating tablets were evaluated. Also determined were the physicomechanical properties, buoyancy and swelling characteristics of the tablets. The in vitro drug release study was carried out according to the USP I (basket method) for 8h in 900 ml 0.1N HCl at 50 rpm. Samples withdrawn at the regular predetermined time were analyzed spectrophotometrically at a wavelength of 271 nm and data obtained statistically analyzed by one-way analysis of variance (ANOVA). The differences between means were considered significant at P<0.05. Results: The result showed that polymer (HPMC) concentration significantly (p>0.05) increased swelling index and improved floating lag time, it had no significant effect on the total floating time. Percentage drug release at the end of 8 h was 100%, 98.2% and 96.13% for formulation F1, F2 and F3, respectively. All three formulations followed the Higuchi drug release kinetics model and the mechanism of drug release was the non Fickian diffusion with exponents of 0.46, 0.51 and 0.56 for the respective batch. Conclusion: Batch F3 gave a better-controlled drug release and floating properties in comparison to batch F1 and F2 thus Polymer concentration influenced the onset of floating and controlled the release of Theophylline.


2011 ◽  
Vol 123 (5) ◽  
pp. 2923-2932 ◽  
Author(s):  
Changwen Zhao ◽  
Pan He ◽  
Chunsheng Xiao ◽  
Xiaoye Gao ◽  
Xiuli Zhuang ◽  
...  

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