scholarly journals Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology

2021 ◽  
Vol 3 ◽  
pp. 100074
Author(s):  
Gauri Shadambikar ◽  
Sushrut Marathe ◽  
Nan Ji ◽  
Mashan Almutairi ◽  
Suresh Bandari ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Formulation Development ◽  
Melt Extrusion ◽  
Pulmonary Aspergillosis ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals Development of an antifungal denture adhesive film for oral candidiasis utilizing hot melt extrusion technology

2014 ◽  
Vol 12 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Jun-Bom Park ◽  
Suneela Prodduturi ◽  
Joe Morott ◽  
Vijay I Kulkarni ◽  
Melissa R Jacob ◽  
...  
Keyword(s):  
Oral Candidiasis ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Adhesive Film ◽  
Denture Adhesive ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

2015 ◽  
Vol 17 (1) ◽  
pp. 158-166 ◽  
Author(s):  
Ajinkya M. Bhagurkar ◽  
Muralikrishnan Angamuthu ◽  
Hemlata Patil ◽  
Roshan V. Tiwari ◽  
Abhijeet Maurya ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Ointment Formulation ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals Effects of formulation composition on the characteristics of mucoadhesive films prepared by hot-melt extrusion technology

2018 ◽  
Vol 71 (3) ◽  
pp. 293-305 ◽  
Author(s):  
Ajinkya M. Bhagurkar ◽  
Mittal Darji ◽  
Prit Lakhani ◽  
Priyanka Thipsay ◽  
Suresh Bandari ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals Preparation of a crystalline salt of indomethacin and tromethamine by hot melt extrusion technology

2018 ◽  
Vol 131 ◽  
pp. 109-119 ◽  
Author(s):  
Mustafa Bookwala ◽  
Priyanka Thipsay ◽  
Samir Ross ◽  
Feng Zhang ◽  
Suresh Bandari ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Crystalline Salt ◽  
Extrusion Technology ◽  
Hot Melt

Preparation, characterization, and pharmacokinetics of tilmicosin taste-masked formulation via hot-melt extrusion technology

2020 ◽  
Vol 196 ◽  
pp. 111293
Author(s):  
Guoqing Yan ◽  
Qiuling Liang ◽  
Xuemei Wen ◽  
Jianbo Peng ◽  
Ruihan Deng ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals Vacuum Compression Molding as a Screening Tool to Investigate Carrier Suitability for Hot-Melt Extrusion Formulations

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1019
Author(s):  
Gauri Shadambikar ◽  
Thomas Kipping ◽  
Nicole Di-Gallo ◽  
Alessandro-Giuseppe Elia ◽  
Anja-Nadine Knüttel ◽  
...  
Keyword(s):  
Screening Tool ◽  
Drug Carriers ◽  
Hot Melt Extrusion ◽  
Compression Molding ◽  
Simulated Gastric Fluid ◽  
Formulation Development ◽  
Melt Extrusion ◽  
Scanning Calorimetry ◽  
Production Scale ◽  
Hot Melt

Hot-melt extrusion (HME) is the most preferred and effective method for manufacturing amorphous solid dispersions at production scale, but it consumes large amounts of samples when used for formulation development. Herein, we show a novel approach to screen the polymers by overcoming the disadvantage of conventional HME screening by using a minimum quantity of active pharmaceutical ingredient (API). Vacuum Compression Molding (VCM) is a fusion-based method to form solid specimens starting from powders. This study aimed to investigate the processability of VCM for the creation of amorphous formulations and to compare its results with HME-processed formulations. Mixtures of indomethacin (IND) with drug carriers (Parteck® MXP, Soluplus®, Kollidon® VA 64, Eudragit® EPO) were processed using VCM and extrusion technology. Thermal characterization was performed using differential scanning calorimetry, and the solid-state was analyzed via X-ray powder diffraction. Dissolution studies in the simulated gastric fluid were performed to evaluate the drug release. Both technologies showed similar results proving the effectiveness of VCM as a screening tool for HME-based formulations.

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