Cyclooxygenase-2 (COX-2) predicts poor survival of T4 nasopharyngeal cancer patients treated by radiation therapy: Clinical and in vitro studies

2004 ◽  
Vol 60 (1) ◽  
pp. S491
Author(s):  
W. Chen ◽  
W.H. McBride ◽  
S. Chen ◽  
T. Hwang ◽  
K. Lee ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Nasopharyngeal Cancer ◽  
Cyclooxygenase 2 ◽  
In Vitro Studies ◽  
Poor Survival ◽  
Cox 2

Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: Clinical and in vitro studies

Head & Neck ◽  
2005 ◽  
Vol 27 (6) ◽  
pp. 503-512 ◽  
Author(s):  
Wen-Cheng Chen ◽  
William H. McBride ◽  
Shih-Ming Chen ◽  
Kam-Fai Lee ◽  
Tzer-Zen Hwang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Nasopharyngeal Cancer ◽  
Cyclooxygenase 2 ◽  
In Vitro Studies ◽  
Poor Survival

scholarly journals The Role of Propolis in Pulp Pain by Inhibiting Cyclooxygenase-2 Expression

2021 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Ira Widjiastuti ◽  
Widya Saraswati ◽  
Annisa Rahma
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Inflammatory Pain ◽  
Cyclooxygenase 2 ◽  
Propolis Extract ◽  
In Silico Studies ◽  
Cox 2

Background: Inflammation of the pulp can lead to elicit pain. Pain in inflammation is induced by the cyclooxygenase-2 enzyme (COX-2) which induces prostaglandin E2 (PGE2) resulting in pain. Pain in the pulp can be relieved by eugenol. In its application, eugenol is toxic to pulp fibroblasts. Due to the side effect, it is worth considering other biocompatible materials with minimal side effects, such as propolis. Flavonoids and phenolic acids that contained in propolis can inhibit COX-2. Therefore, an analysis outlined in the literature review is needed to examine the results of research related to the role of propolis as pulp pain relief by inhibiting COX-2 expression. Purpose: To analyze the role of propolis in pulp pain by inhibiting COX-2 expression. Reviews: Propolis extract that extracted by ethanol, water, and hydroalcohol has pain relief properties in the pulp by inhibiting COX-2 by directly binding to the COX-2 receptors and by reducing the production of proinflammatory cytokines which are COX-2 inducers, proven through in vivo, in vitro, and in silico studies in various target cell organs. Conclusion: Propolis extract has high prospect as inflammatory pain inhibitor in the pulp by inhibit COX-2 expression.

scholarly journals Impact of new cyclooxygenase 2 inhibitors on human cytomegalovirus replication in vitro

2021 ◽  
pp. 135965352110640
Author(s):  
D Andouard ◽  
R Gueye ◽  
S Hantz ◽  
C Fagnère ◽  
B Liagre ◽  
...  
Keyword(s):  
Human Cytomegalovirus ◽  
Hcmv Infection ◽  
Laboratory Strain ◽  
Cyclooxygenase 2 ◽  
Immunocompromised Patients ◽  
Toxic Compound ◽  
Cox 2 ◽  
Cyclooxygenase 2 Inhibitors ◽  
Strain Ad169

Background Human cytomegalovirus (HCMV) is involved in complications on immunocompromised patients. Current therapeutics are associated with several drawbacks, such as nephrotoxicity. Purpose: As HCMV infection affects inflammation pathways, especially prostaglandin E2 (PGE2) production via cyclooxygenase 2 enzyme (COX-2), we designed 2'-hydroxychalcone compounds to inhibit human cytomegalovirus. Study design We first selected the most efficient new synthetic chalcones for their effect against COX-2-catalyzed PGE2. Study sample Among the selected compounds, we assessed the antiviral efficacy against different HCMV strains, such as the laboratory strain AD169 and clinical strains (naïve or multi-resistant to conventional drugs) and toxicity on human cells. Results The most efficient and less toxic compound (chalcone 7) was tested against HCMV in combination with other antiviral molecules: artesunate (ART), baicalein (BAI), maribavir (MBV), ganciclovir (GCV), and quercetin (QUER) using Compusyn software. Association of chalcone 7 with MBV and BAI is synergistic, antagonistic with QUER, and additive with GCV and ART. Conclusion These results provide a promising search path for potential bitherapies against HCMV.

Symptom Profile of Nasopharyngeal Cancer Patients during Radiation Therapy

2008 ◽  
Vol 8 (6) ◽  
pp. 274-281 ◽  
Author(s):  
Hsiu-Ying Huang ◽  
Diana J. Wilkie ◽  
Mark M. Schubert ◽  
Lai-Lei Ting
Keyword(s):  
Radiation Therapy ◽  
Cancer Patients ◽  
Nasopharyngeal Cancer ◽  
Symptom Profile

Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells

2018 ◽  
Vol 206 (1-2) ◽  
pp. 46-53 ◽  
Author(s):  
Maryam Sadat Tafakh ◽  
Massoud Saidijam ◽  
Tayebeh Ranjbarnejad ◽  
Sara Malih ◽  
Solmaz Mirzamohammadi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Caspase 3 ◽  
Mrna Level ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Prostaglandin E Synthase ◽  
Cox 2 ◽  
Ht 29 ◽  
Microsomal Prostaglandin E Synthase

Background: A high expression of prostaglandin E2 (PGE2) is found in colorectal cancer. Therefore, blocking of PGE2 generation has been identified as a promising approach for anticancer therapy. Sulforaphane (SFN), an isothiocyanate derived from glucosinolate, is used as the antioxidant and anticancer agents. Methods: HT-29 cells were treated with various concentrations of SFN and compared to untreated cells for the expression of microsomal prostaglandin E synthase-1 (mPGES-1), cyclooxygenase 2 (COX-2), hypoxia-inducible factor-1 (HIF-1), C-X-C chemokine receptor type 4 (CXCR4), vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-2 and MMP-9 at the mRNA level. The PGE2 level was measured by ELISA assay. Apoptosis was evaluated by the proportion of sub-G1 cells. The activity of caspase-3 was determined using an enzymatic assay. HT-29 cell migration was assessed using a scratch test. Results: SFN preconditioning decreased the expression of COX-2, mPGES-1, HIF-1, VEGF, CXCR4, MMP-2, and MMP-9. An apoptotic effect of SFN was preceded by the activation of caspase-3 as well as accumulation of cells in the sub-G1 phase of the cell cycle. SFN decreased PGE2 generation and inhibited the in vitro motility/wound-healing activity of HT-29 cells. Conclusions: SFN anticancer effects are associated with antiproliferative, antiangiogenic, and antimetastatic activities arising from the downregulation of the COX-2/ mPGES-1 axis.

Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398

2004 ◽  
Vol 19 (6) ◽  
pp. 638-642 ◽  
Author(s):  
HONG-PING YU ◽  
LU-YUAN SHI ◽  
WEN-HONG LU ◽  
YAN-HUA SU ◽  
YUAN-YUAN LI ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cyclooxygenase 2 ◽  
In Vitro Inhibition ◽  
Cox 2 ◽  
Human Esophageal Cancer

scholarly journals Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients

2002 ◽  
Vol 13 (8) ◽  
pp. 1205-1211 ◽  
Author(s):  
G. Ferrandina ◽  
L. Lauriola ◽  
G.F. Zannoni ◽  
A. Fagotti ◽  
F. Fanfani ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Chemotherapy Resistance ◽  
Cyclooxygenase 2 ◽  
Cox 2

Radiosynthesis of a 18F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo

2012 ◽  
Vol 20 (11) ◽  
pp. 3410-3421 ◽  
Author(s):  
Torsten Kniess ◽  
Markus Laube ◽  
Ralf Bergmann ◽  
Fabian Sehn ◽  
Franziska Graf ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Cyclooxygenase 2 ◽  
Cox 2
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