An On-line Adaptive Strategy for Cervical Cancer Patients Based on Pre-treatment Acquired Variable Bladder Filling CT-scans and In-room Bladder Volume Measurements

2010 ◽  
Vol 78 (3) ◽  
pp. S184-S185
Author(s):  
B. Heijmen ◽  
L. Bondar ◽  
J. Mens ◽  
G. Dhawtal ◽  
S. Quint ◽  
...  
Brachytherapy ◽  
2015 ◽  
Vol 14 ◽  
pp. S74
Author(s):  
Oana Craciunescu ◽  
Taoran Li ◽  
Zhang Chang ◽  
Beverly Steffey ◽  
Sheridan Meltsner ◽  
...  

2020 ◽  
Author(s):  
Hong-tao Guo ◽  
Xue-han Bi ◽  
Ting Lei ◽  
Xiao Lv ◽  
Guang Yao ◽  
...  

Abstract Background : For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be administered with adjuvant chemotherapy is unknown. The current study was designed to explore the clinical value of squamous cell carcinoma antigen (SCC-Ag) in guiding the use of adjuvant chemotherapy in cervical cancer patients. Methods : A retrospective study of 301 cervical cancer patients treated by surgery and adjuvant treatment from March 2006 to March 2016 was performed. All patients were divided into two groups according to receiving adjuvant chemotherapy or not. Overall survival (OS), disease-free survival (DFS) were compare between patients who did and did not receive adjuvant radiotherapy. Multivariate analysis was employed to detect clinical factors associated with disease-free survival, local recurrence-free survival and distant metastasis-free survival. Results: For patients with high pre-treatment SCC-Ag level, DFS and OS in adjuvant chemo-radiotherapy group were higher than that in adjuvant radiotherapy group. Besides, the rates of distant metastasis were found lower in patients who did receive adjuvant chemotherapy than those who did not. For patients with low pre-treatment SCC-Ag level, the 5-year OS and DFS were similar between groups of adjuvant chemo-radiotherapy and adjuvant radiotherapy. Multivariable analysis indicated adjuvant chemotherapy was independent predictors of DFS and distant metastasis-free survival (DMFS) in patients with high SCC-Ag level. Conclusion: SCC-Ag can serve as an indication for the administration of adjuvant chemotherapy in cervical cancer patients.


2021 ◽  
Vol 161 ◽  
pp. S1653-S1654
Author(s):  
C. Nelder ◽  
R. Chuter ◽  
J. Berresford ◽  
R. Benson ◽  
A. Clough ◽  
...  

2008 ◽  
Vol 89 (2) ◽  
pp. 172-179 ◽  
Author(s):  
Rozilawati Ahmad ◽  
Mischa S. Hoogeman ◽  
Sandra Quint ◽  
Jan Willem Mens ◽  
Ilse de Pree ◽  
...  

Brachytherapy ◽  
2016 ◽  
Vol 15 ◽  
pp. S160-S161
Author(s):  
Oana Craciunescu ◽  
Austin Faught ◽  
Zhang Chang ◽  
Jing Cai ◽  
Beverly A. Steffey ◽  
...  

Ultrasound ◽  
2021 ◽  
pp. 1742271X2199521
Author(s):  
L Smith ◽  
J Gittins ◽  
KV Ramnarine ◽  
EML Chung

Introduction During prostate radiotherapy treatment, it is important to ensure the position of the bladder and prostate is consistent between treatments. The aim of this study was to provide a quantitative basis for incorporating ultrasound bladder volume estimates into local practice for prostate radiotherapy. Methods Agreement between bladder volume estimates obtained using computed tomography (CT) and ultrasound was assessed. Analysis of bladder volumes between planning and treatment scans was used to quantify expected variations in bladder volume over the course of radiotherapy. Dose–volume statistics were estimated and compared to planned dose constraints to propose a target bladder volume and tolerance. Results Bladder volume measurements were obtained from 19 radiotherapy patients using ultrasound and CT. Ultrasound underestimated bladder volume compared to CT with a mean bias of –28 ± 30 ml. Pre-treatment (planning) bladder volumes varied from 71 to 383 ml with a mean of 200 ml. Treatment bladder volumes reduced by more than half in 9% of patients during the course of their treatment, potentially leading to a 30% increase in mean bladder dose. Patients with pre-treatment bladder volumes < 200 ml were most likely to exhibit differences in bladder volume, resulting in ‘out of tolerance’ increases in dose. Conclusions A pragmatic individualised drinking protocol, aimed at achieving a minimum ultrasound bladder volume of 200 ml at planning CT, may be beneficial to reproducibility in radiotherapy treatment. Ultrasound measurements prior to treatment should ideally confirm that bladder volume is at least half the volume measured at planning.


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