Assessment of Quality of Life (QOL) in Phase III Trials of Radiotherapy (RT) in Localized or Locally Advanced Head and Neck Cancer (HNC) over the Past Decade

2011 ◽  
Vol 81 (2) ◽  
pp. S543-S544
Author(s):  
G.N. Marta ◽  
S.A. Hanna ◽  
J.L.F. Da Silva ◽  
E.D. Saad
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Phase Iii ◽  
Advanced Head ◽  
The Past ◽  
Phase Iii Trials

Five-year quality of life results of the randomized clinical phase III (RADPLAT) trial, comparing concomitant intra-arterial versus intravenous chemoradiotherapy in locally advanced head and neck cancer

Head & Neck ◽  
2011 ◽  
Vol 34 (7) ◽  
pp. 974-980 ◽  
Author(s):  
Annemieke H. Ackerstaff ◽  
Coen R. N. Rasch ◽  
Alfons J. M. Balm ◽  
Jan Paul de Boer ◽  
Ruud Wiggenraad ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Phase Iii ◽  
Advanced Head ◽  
Clinical Phase

scholarly journals Is the introduction of more advanced radiotherapy techniques for locally-advanced head and neck cancer associated with improved quality of life and reduced symptom burden?

2020 ◽  
Vol 151 ◽  
pp. 298-303
Author(s):  
Max Dahele ◽  
Jim P. Tol ◽  
Marije R. Vergeer ◽  
Femke Jansen ◽  
Birgit I. Lissenberg-Witte ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Symptom Burden ◽  
Advanced Head ◽  
Radiotherapy Techniques

Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer

2015 ◽  
Vol 191 (6) ◽  
pp. 501-510 ◽  
Author(s):  
Silke Tribius ◽  
Marieclaire Raguse ◽  
Christian Voigt ◽  
Adrian Münscher ◽  
Alexander Gröbe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
One Year

Impact of systemic treatment associated to radiotherapy on quality of life in locally advanced head and neck cancer patients in Brazil: Prospective real-world data study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e17563-e17563
Author(s):  
Marcos Antonio Santos ◽  
Luis Felipe Oliveira e Silva ◽  
Hugo Fontan Kohler ◽  
Otavio Curioni ◽  
Ricardo Alencar Vilela ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Alcohol Consumption ◽  
Head And Neck ◽  
Neck Cancer ◽  
Real World ◽  
Systemic Treatment ◽  
Locally Advanced ◽  
Advanced Head

e17563 Background: the purpose of this study was to compare quality of life (QoL) and overall survival (OS) in patients with locally advanced head and neck cancer treated with radiotherapy only (RT), chemoradiotherapy with cisplatin (CT-RT) or RT with cetuximab (CET-RT). Methods: in this real-world, multi-institutional and prospective study, QoL outcomes were assessed using EORTC QLQ-C30 and QLQ-H&N43 questionnaires. Patients were treated according to each participating institution’s protocol. The Item Response Theory was used to generate a global QoL score, based on the 71 questions of both forms. Questionnaires were completed before treatment and every three months, thereafter. Survival was calculated using the Kaplan-Meyer method, and groups were compared by the log-rank test. The impact of the treatment modalities on QoL was analyzed using multivariate regression analyses. Results: Six hundred and twenty-six patients, with tumors located at the oral cavity (36%), oropharynx (30%), larynx (21%), hypopharynx (9%) and nasopharynx (4%) were included. Median follow up was 10.2 months. RT was delivered to 39% of the patients while 58% received CT-RT and 3% received CET-RT. Patients submitted to surgery were not included. OS was higher when systemic treatment was added to RT (median OS CET-RT: 21.9 months and CT-RT: 24.3 months, versus 14.2 months with RT, p < 0.05). A decrease in QoL during treatment was observed in all patients’ groups, but CT-RT had a statistically significant negative impact on QoL when compared to CET-RT (p = 0.02). An important limitation of the study is the low number of patients that received this last treatment modality, what is, probably, a result of local policies on reimbursement. Other factors that influenced QoL were alcohol consumption (better QoL for patients with no history of chronic alcohol consumption, p = 0.007) and radiotherapy technique (better QoL for patients treated with intensity-modulated RT, when compared to conformal RT, p < 0.001). Conclusions: We observed, as expected, better OS with systemic therapy, when associated to RT. A decrease in QoL was detected, as well, during treatment, but a less pronounced decrease was seen in patients receiving CET-RT, when compared to CT-RT. More studies are needed to confirm the QoL improvement in patients submitted to this last treatment approach.

Quality of life scores as prognostic factors of overall survival in advanced head and neck cancer: Analysis of a phase III randomized trial of pemetrexed plus cisplatin versus cisplatin monotherapy

Oral Oncology ◽  
2012 ◽  
Vol 48 (8) ◽  
pp. 723-729 ◽  
Author(s):  
Susan Urba ◽  
Jennifer Gatz ◽  
Wei Shen ◽  
Anwar Hossain ◽  
Katherine Winfree ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Randomized Trial ◽  
Head And Neck ◽  
Neck Cancer ◽  
Phase Iii ◽  
Advanced Head

Quality of life in patients with locally advanced head and neck cancer treated with chemoradiotherapy. Comparison of two protocols using the EORTC questionnaires (QLQ-C30, H&N35)

2005 ◽  
Vol 7 (9) ◽  
pp. 398-403 ◽  
Author(s):  
Juan Ignacio Arraras Urdaniz ◽  
Fernando Arias de la Vega ◽  
Ana Manterola Burgaleta ◽  
Ruth Vera García ◽  
Maite Martínez Aguillo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head

Quality of Life following Chemoradiation and Postoperative Radiation for Locally Advanced Head and Neck Cancer

ORL ◽  
2007 ◽  
Vol 69 (5) ◽  
pp. 271-276 ◽  
Author(s):  
Nam P. Nguyen ◽  
Paul Vos ◽  
Ulf Karlsson ◽  
Phuc Nguyen ◽  
Suresh Dutta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head ◽  
Postoperative Radiation
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