Effect of Dosimetric Factors on Occurrence and Volume of Temporal Lobe Necrosis Following Intensity Modulated Radiation Therapy for Nasopharyngeal Carcinoma: A Case-Control Study

2014 ◽  
Vol 90 (1) ◽  
pp. S181
Author(s):  
X. Zhou ◽  
C. Hu ◽  
C. Shen ◽  
X. Wang ◽  
T. Xu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Case Control Study ◽  
Intensity Modulated Radiation Therapy ◽  
Case Control ◽  
Intensity Modulated ◽  
Temporal Lobe Necrosis ◽  
Control Study

scholarly journals Temporal Lobe Necrosis Following Radiotherapy in Nasopharyngeal Carcinoma: New Insight Into the Management

2021 ◽  
Vol 10 ◽  
Author(s):  
Xin Zhou ◽  
Peiyao Liu ◽  
Xiaoshen Wang
Keyword(s):  
Radiation Therapy ◽  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Intensity Modulated Radiation Therapy ◽  
Therapeutic Interventions ◽  
Humanized Monoclonal Antibody ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced ◽  
Endothelial Growth Factor

Cerebral radiation necrosis (CRN) is one of the most prominent sequelae following radiation therapy for nasopharyngeal carcinoma (NPC), which might have devastating effects on patients’ quality of life (QOL). Advances in histopathology and neuro-radiology have shed light on the management of CRN more comprehensively, yet effective therapeutic interventions are still lacking. CRN was once regarded as progressive and irreversible, however, in the past 20 years, with the application of intensity-modulated radiation therapy (IMRT), both the incidence and severity of CRN have declined. In addition, newly developed medical agents including bevacizumab-a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), nerve growth factor (NGF), monosialotetrahexosylganglioside (GM1), etc., have shown great potency in successfully reversing radiation-induced CRN. As temporal lobes are most frequently compromised in NPC patients, this review will summarize the state-of-the-art progress regarding the incidence, pathophysiology, prevention, treatment, and prognosis of temporal lobe necrosis (TLN) after IMRT in NPC.

Sign in / Sign up

Export Citation Format

Share Document