scholarly journals Oropharyngeal Cancer Treated With Transoral Surgery (TOS) and Radiation Therapy to the Neck With Omission of the Primary Site: A Radiation Therapy Dosimetric Analysis

2015 ◽  
Vol 93 (3) ◽  
pp. S70-S71
Author(s):  
M.E. Gamez ◽  
M.Y. Halyard ◽  
C. Vargas ◽  
W.W. Wong ◽  
S.H. Patel
Keyword(s):  
Radiation Therapy ◽  
Oropharyngeal Cancer ◽  
Primary Site ◽  
Transoral Surgery ◽  
Dosimetric Analysis

Mucosal Sparing Radiation Therapy in Resected Oropharyngeal Cancer

2017 ◽  
Vol 126 (3) ◽  
pp. 185-191 ◽  
Author(s):  
Mauricio E. Gamez ◽  
Michele Y. Halyard ◽  
Michael L. Hinni ◽  
Richard E. Hayden ◽  
Thomas H. Nagel ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oropharyngeal Cancer ◽  
Intensity Modulated Radiation Therapy ◽  
Distant Metastases ◽  
Target Volume ◽  
Primary Site ◽  
Transoral Surgery ◽  
Adjuvant Radiation ◽  
Primary Base

Purpose: To report the outcomes of patients with favorable risk oropharyngeal cancer that underwent adjuvant radiation therapy with omission of the primary site from the clinical target volume (CTV). Material/Methods: A retrospective study of 40 patients treated with transoral surgery (TOS) followed by neck only radiation using intensity modulated radiation therapy (IMRT) with exclusion of the primary site. For all patients, a CTV of the primary surgical bed was contoured to obtain the estimated incidental dose to the primary site. Results: Median follow-up was 51 months (range, 13-155 months). The median radiation therapy (RT) dose to the neck was 6000 cGy (range, 5400-6400 cGy). The mean incidental dose to the primary tonsillar site was 4320 cGy (SD ± 480 cGy) and to the primary base of tongue site was 4060 cGy (SD ± 420 cGy). There were no local failures and only 1 regional failure, resulting in 97.5% locoregional control rate at 4 years. Two patients developed distant metastases, without evidence of locoregional recurrence, for a 4-year overall survival rate of 97%. Conclusions: Our analysis suggests that mucosal sparing RT after TOS in favorable risk oropharyngeal cancer patients may provide comparable oncologic and improved functional outcomes compared to conventional treatment in selected patients.

scholarly journals Determining the Impact of Thickened Liquids on Swallowing in Patients Undergoing Irradiation for Oropharynx Cancer

2021 ◽  
pp. 019459982110104
Author(s):  
Carly E. A. Barbon ◽  
Douglas B. Chepeha ◽  
Andrew J. Hope ◽  
Melanie Peladeau-Pigeon ◽  
Ashley A. Waito ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Clinical Benefit ◽  
Oropharyngeal Cancer ◽  
Thickened Liquids ◽  
Current Standard ◽  
Oropharynx Cancer ◽  
Post Radiation ◽  
Thin Liquids ◽  
The Impact

The current standard for the treatment of oropharynx cancers is radiation therapy. However, patients are frequently left with dysphagia characterized by penetration-aspiration (impaired safety) and residue (impaired efficiency). Although thickened liquids are commonly used to manage dysphagia, we lack evidence to guide the modification of liquids for clinical benefit in the head and neck cancer population. The objective of this study was to assess the impact of slightly and mildly thick liquids on penetration-aspiration and residue in 12 patients with oropharyngeal cancer who displayed penetration-aspiration on thin liquid within 3 to 6 months after completion of radiotherapy. Significantly fewer instances of penetration-aspiration were seen with slightly and mildly thick liquids as compared with thin ( P < .05). No differences were found across stimuli in the frequency of residue. Patients with oropharyngeal cancers who present with post–radiation therapy dysphagia involving penetration-aspiration on thin liquids may benefit from slightly and mildly thick liquids without risk of worse residue.

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