Should Radiation Therapy be Avoided in Breast Cancer Patients with Li-Fraumeni Syndrome?

2019 ◽  
Vol 105 (1) ◽  
pp. E55
Author(s):  
P. Hendrickson ◽  
Y. Luo ◽  
W. Kohlmann ◽  
J. Schiffman ◽  
K.E. Kokeny ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Li Fraumeni Syndrome ◽  
Li Fraumeni

Radiotherapy-induced malignancies in breast cancer patients with TP53 pathogenic germline variants (Li–Fraumeni syndrome)

2019 ◽  
Vol 19 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Vanessa Petry ◽  
Renata Colombo Bonadio ◽  
Allyne Queiroz Carneiro Cagnacci ◽  
Luiz Antonio Leite Senna ◽  
Roberta do Nascimento Galvão Campos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Germline Variants ◽  
Li Fraumeni Syndrome ◽  
Li Fraumeni

scholarly journals Breast cancer patients suggestive of Li-Fraumeni syndrome: mutational spectrum, candidate genes, and unexplained heredity

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Judith Penkert ◽  
Gunnar Schmidt ◽  
Winfried Hofmann ◽  
Stephanie Schubert ◽  
Maximilian Schieck ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Candidate Genes ◽  
Breast Cancer Patients ◽  
Li Fraumeni Syndrome ◽  
Mutational Spectrum ◽  
Li Fraumeni

scholarly journals Adjuvant radiotherapy induces secondary tumor events in breast cancer patients with Li-Fraumeni syndrome

2019 ◽  
Vol 30 ◽  
pp. iii30
Author(s):  
K. Rounis ◽  
T. Koukaki ◽  
C. Christodoulou ◽  
C. Papadimitriou ◽  
D. Tryfonopoulos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Adjuvant Radiotherapy ◽  
Breast Cancer Patients ◽  
Li Fraumeni Syndrome ◽  
Secondary Tumor ◽  
Li Fraumeni

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

Implant Reconstruction in Breast Cancer Patients Treated with Radiation Therapy

2006 ◽  
Vol 117 (2) ◽  
pp. 359-365 ◽  
Author(s):  
Jeffrey A. Ascherman ◽  
Matthew M. Hanasono ◽  
Martin I. Newman ◽  
Duncan B. Hughes
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Implant Reconstruction
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