Pancreatic Non-Hodgkin Lymphoma, a rare cause for obstructive jaundice. A Case reports

Introduction. Non Hodgkin lymphoma (NHL) presenting with obstructive jaundice is a rare occurrence. Because of rarity of combination, it is seldom considered in differential diagnosis of patients presenting with obstructive jaundice. It is considered treatable due to the chemosensitive nature of the disease and the recent advances in chemotherapy.Case Series. We present a case series of 2 patients with NHL presenting with obstructive jaundice as an initial manifestation. Both patients presented with obstructive jaundice and were diagnosed by CT guided liver biopsy. One patient died of sepsis and multiorgan failure before initiating chemotherapy and the second patient did not choose to undergo chemotherapy.Conclusion. Biliary obstruction is a sign of poor prognosis. The diagnosis of NHL needs to be considered in patients presenting with biliary obstruction. It can be associated with high mortality and poses treatment dilemma.

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Non-Hodgkin Lymphoma of External Auditory Canal – Uncommon Location and Related Risk Factors

Journal of Clinical Case reports and Images ◽

10.14302/issn.2641-5518.jcci-17-1880 ◽

2018 ◽

Vol 1 (1) ◽

pp. 16-22

Author(s):

Bassem A D A D Mettias ◽

Hisham Zeitoun

Keyword(s):

Hodgkin Lymphoma ◽

Facial Paralysis ◽

External Auditory Canal ◽

Case Reports ◽

High Dose ◽

Non Hodgkin Lymphoma ◽

Related Risk ◽

Response To Chemotherapy ◽

Rare Case Report ◽

External Canal

Objective: Presentation of rare case report of primary non-Hodgkin Lymphoma of temporal bone secondary to immunodeficiency after prolonged steroid administration in a diabetic patient. Then review the literature of similar case reports. Method: 49 years old female presented with hearing loss, facial paralysis and otalgia. Biopsy revealed high grade non Hodgkin’s B-lymphoma. She underwent chemotherapy and had remarkable response. Result: Rapidly progressive deafness, facial paralysis and otalgia are common presentations of external canal Non-Hodgkin lymphoma. The disease is common in middle age, females and has a fair response to chemotherapy, good to radiotherapy. Surgery is an alternative method in isolated lesions or recurrent cases. Conclusion: High dose steroid and type II diabetes are potential risks for acquired immunodeficiency. External Auditory canal lymphoma is uncommon sequel. Chemotherapy is very effective in treatment of isolated cases without B symptoms

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Obstructive Jaundice Caused by Non-Hodgkin Lymphoma in Common Bile Duct

The Journal of Pediatrics ◽

10.1016/j.jpeds.2015.08.019 ◽

2015 ◽

Vol 167 (5) ◽

pp. 1168-1168.e1

Author(s):

Tianyou Yang ◽

Jing Pan ◽

Yan Zou

Keyword(s):

Bile Duct ◽

Common Bile Duct ◽

Obstructive Jaundice ◽

Hodgkin Lymphoma ◽

Non Hodgkin Lymphoma

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Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden

Blood ◽

10.1182/blood-2008-12-191676 ◽

2009 ◽

Vol 114 (4) ◽

pp. 791-795 ◽

Cited By ~ 95

Author(s):

Ola Landgren ◽

Sigurdur Y. Kristinsson ◽

Lynn R. Goldin ◽

Neil E. Caporaso ◽

Cecilie Blimark ◽

...

Keyword(s):

Hodgkin Lymphoma ◽

Monoclonal Gammopathy ◽

Case Reports ◽

Population Based ◽

Lymphocytic Leukemia ◽

Degree Relative ◽

First Degree Relatives ◽

Non Hodgkin Lymphoma ◽

Increased Risk ◽

Undetermined Significance

Abstract Familial clustering of the precursor condition, monoclonal gammopathy of undetermined significance (MGUS) has been observed in case reports and in smaller studies. Using population-based data from Sweden, we identified 4458 MGUS patients, 17505 population-based controls, and first-degree relatives of patients (n = 14621) and controls (n = 58387) with the aim to assess risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients. Compared with relatives of controls, relatives of MGUS patients had increased risk of MGUS (relative risk [RR] = 2.8; 1.4-5.6), multiple myeloma (MM; RR = 2.9; 1.9-4.3), lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM; RR = 4.0; 1.5-11), and chronic lymphocytic leukemia (CLL; RR = 2.0; 1.2-2.3). Relatives of patients with IgG/IgA MGUS had a 4.0-fold (1.7-9.2), 2.9-fold (1.7-4.9), and 20-fold (2.3-170) elevated risk of developing MGUS, MM, and LPL/WM, respectively. Relatives of IgM MGUS patients had 5.0-fold (1.1-23) increased CLL risk and nonsignificant excess MM and LPL/WM risks. The results were very similar when we assessed risk by type of first-degree relative, age at MGUS (above/below 65 years), or sex. Risk of non-Hodgkin lymphoma or Hodgkin lymphoma was not increased among MGUS relatives. Among first-degree relatives of a nationwide MGUS cohort, we found elevated risks of MGUS, MM, LPL/WM, and CLL, supporting a role for germline susceptibility genes, shared environmental influences, or an interaction between both.

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